ID SPC24_ASPFU Reviewed; 200 AA. AC Q4X0I7; DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot. DT 25-JUL-2006, sequence version 2. DT 11-NOV-2015, entry version 59. DE RecName: Full=Probable kinetochore protein spc24; GN Name=spc24; ORFNames=AFUA_2G13330; OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC OS A1100) (Aspergillus fumigatus). OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes; OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus. OX NCBI_TaxID=330879; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100; RX PubMed=16372009; DOI=10.1038/nature04332; RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., RA Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., RA Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., RA Farman M.L., Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., RA Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., RA Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., RA Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., RA Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., RA Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., RA Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., RA Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., RA Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., RA Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., RA Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., RA Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., RA White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., RA Machida M., Hall N., Barrell B.G., Denning D.W.; RT "Genomic sequence of the pathogenic and allergenic filamentous fungus RT Aspergillus fumigatus."; RL Nature 438:1151-1156(2005). CC -!- FUNCTION: Acts as a component of the essential kinetochore- CC associated NDC80 complex, which is required for chromosome CC segregation and spindle checkpoint activity. {ECO:0000250}. CC -!- SUBUNIT: Component of the NDC80 complex, which consists of at CC least ndc80, nuf2 and spc24. {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, CC centromere, kinetochore {ECO:0000250}. Note=Associated with CC kinetochores. {ECO:0000250}. CC -!- SIMILARITY: Belongs to the SPC24 family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=EAL93628.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AAHF01000001; EAL93628.1; ALT_SEQ; Genomic_DNA. DR RefSeq; XP_755666.1; XM_750573.1. DR GeneID; 3513168; -. DR KEGG; afm:AFUA_2G13330; -. DR EuPathDB; FungiDB:Afu2g13330; -. DR HOGENOM; HOG000165387; -. DR InParanoid; Q4X0I7; -. DR KO; K11557; -. DR OrthoDB; EOG7R83D4; -. DR Proteomes; UP000002530; Chromosome 2. DR GO; GO:0000778; C:condensed nuclear chromosome kinetochore; IEA:EnsemblFungi. DR GO; GO:0005829; C:cytosol; IEA:EnsemblFungi. DR GO; GO:0044732; C:mitotic spindle pole body; IEA:EnsemblFungi. DR GO; GO:0031262; C:Ndc80 complex; IEA:EnsemblFungi. DR GO; GO:0031617; C:NMS complex; IEA:EnsemblFungi. DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW. DR GO; GO:0000070; P:mitotic sister chromatid segregation; IEA:EnsemblFungi. DR InterPro; IPR013252; Ndc80_Spc24. DR Pfam; PF08286; Spc24; 1. PE 3: Inferred from homology; KW Cell cycle; Cell division; Centromere; Chromosome; Coiled coil; KW Complete proteome; Kinetochore; Mitosis; Nucleus; Reference proteome. FT CHAIN 1 200 Probable kinetochore protein spc24. FT /FTId=PRO_0000246658. FT COILED 39 129 {ECO:0000255}. SQ SEQUENCE 200 AA; 22783 MW; 1A83BFE1FFA0958D CRC64; MLLDEDPATL IHHTIGNFNI QPDKQAVTRI NDSLSTLQQS RELRMRDAES ALRKLSRNLH ALTAQHEEAV SSHDSAKHAA QMVELDTKKF RIAKAATELE IESERLEGEL EMLKERLAEL EAQGLEGDEA TRREREADDA TILRLKIYRS LGIDIEADEA GNFSKAVIRN SRKGDVHVVN MDPKFSRFFY ANYFWSTMQG //