ID STE20_ASPFU STANDARD; PRT; 986 AA. AC Q4WHP3; DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot. DT 05-JUL-2005, sequence version 1. DT 30-MAY-2006, entry version 13. DE Serine/threonine-protein kinase ste20 (EC 2.7.11.1). GN Name=ste20; ORFNames=Afu2g04680; OS Aspergillus fumigatus (Sartorya fumigata). OC Eukaryota; Fungi; Ascomycota; Pezizomycotina; Eurotiomycetes; OC Eurotiales; Trichocomaceae; mitosporic Trichocomaceae; Aspergillus. OX NCBI_TaxID=5085; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Af293 / CBS 101355 / FGSC A1100; RX PubMed=16372009; DOI=10.1038/nature04332; RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., RA Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., RA Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., RA Farman M.L., Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., RA Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., RA Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., RA Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., RA Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., RA Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., RA Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., RA Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., RA Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., RA Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., RA Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., RA Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., RA White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., RA Machida M., Hall N., Barrell B.G., Denning D.W.; RT "Genomic sequence of the pathogenic and allergenic filamentous fungus RT Aspergillus fumigatus."; RL Nature 438:1151-1156(2005). CC -!- FUNCTION: MAP4K component of the MAPK pathway required for the CC mating pheromone response and the regulation of cell polarity and CC cell cycle (By similarity). CC -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. CC -!- PATHWAY: Response to pheromone-induced signal. CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By CC similarity). CC -!- SIMILARITY: Belongs to the Ser/Thr protein kinase family. STE20 CC subfamily. CC -!- SIMILARITY: Contains 1 CRIB domain. CC -!- SIMILARITY: Contains 1 protein kinase domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AAHF01000008; EAL87562.1; -; Genomic_DNA. DR InterPro; IPR011009; Kinase_like. DR InterPro; IPR000095; PAK_box_Rho_bd. DR InterPro; IPR000719; Prot_kinase. DR InterPro; IPR008271; Ser_thr_pkin_AS. DR InterPro; IPR002290; Ser_thr_pkinase. DR InterPro; IPR011026; WASP_C. DR Pfam; PF00786; PBD; 1. DR Pfam; PF00069; Pkinase; 1. DR ProDom; PD000001; Prot_kinase; 1. DR SMART; SM00285; PBD; 1. DR SMART; SM00220; S_TKc; 1. DR PROSITE; PS50108; CRIB; 1. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1. KW ATP-binding; Complete proteome; Kinase; Nuclear protein; KW Nucleotide-binding; Pheromone response; KW Serine/threonine-protein kinase; Transferase. FT CHAIN 1 986 Serine/threonine-protein kinase ste20. FT /FTId=PRO_0000237626. FT DOMAIN 394 407 CRIB. FT DOMAIN 705 956 Protein kinase. FT NP_BIND 711 719 ATP (By similarity). FT COMPBIAS 195 282 Ser-rich. FT COMPBIAS 485 576 Pro-rich. FT COMPBIAS 592 682 Gln-rich. FT ACT_SITE 824 824 Proton acceptor (By similarity). FT BINDING 734 734 ATP (By similarity). SQ SEQUENCE 986 AA; 109435 MW; C134F434B9195D55 CRC64; MTEFFMRGCQ AKSFPRLAKQ VATVLEKFKF HPVTMIWGTS TNSRFRIKDN NKKVPLIYPQ LPIGVLSCRT YAFFLQPAAA LHVLNRWLLR SRLARGSFFR SLYLGFHPVP QITQSLQQHS DPSTYPLRKS ATAKKKIQQG YPGAPPQLVA FPHLFPIEPL KHTCHPPCHY TSIRRTPLLI AHHEQRRKLQ KDPPSVSSRI LRSQQSNTSL KRHPSAPVHP RSSVTGSREH SRTRSNAYGS SSSSLEQHSG GPSPVLAGGD SNNSFSSKSR PGRFSFNTDP SSDELTGSPF DSRGMLSALE ENTAESEKSP PPQPPTLRSY HTSPDSRGLR QSASFTALQN RMDTFTQKSE NDQSTNTKRH SDEANGTKVF GRSKKSSFSS FVNSMLGSPR GIKISAPENP VHVTHVGYDN QTGQFTGLPK EWQRLLQENG ISKKEQEEHP QTMVDIMRFY EKNARGDDEV WHKFDHAYAH HQPTANTPGS QRNSPPTSPR FPQNHEGSFE NPRAPPPIPR GAPAATQAMS PPIGGLVPSR APPKPPAPAN MIPARPAPQP PVARPPQDAY ANQFSTPPIS ESEPLPSEAQ RSRSNSKTNG AQPQWAQPGA IASPAQYQQQ QEQAMAAAQQ AIVQNQLERS RSQRQQQSRG PEPKQPTQMG HSQHANDHTT ALQSPQKAQP VPAARPRQRA RQSNAVDVRA RLLAICTPGD PTKLYYNLNK IGQGASGGVY TAYQHGTNNC VAIKQMNLDL QPKKELIINE ILVMKDSKHK NIVNFLDSYL HGLDLWVVME YMEGGSLTDV VTFNIMTEGQ IAAVCRETLN GLQHLHSKGV IHRDIKSDNI LLSLDGNIKL TDFGFCAQIN DSQNKRNTMV GTPYWMAPEV VTRKEYGRKV DIWSLGIMAI EMIEGEPPYL TESPLRALYL IATNGTPTIK DEHNLSPVFR DFLHLALKVD PEKRASAHDL LMHPFMSLCS PLTHLAPLVK AARLSRAQEK AQKGGA //