ID Q4VA34_MOUSE Unreviewed; 224 AA. AC Q4VA34; DT 05-JUL-2005, integrated into UniProtKB/TrEMBL. DT 05-JUL-2005, sequence version 1. DT 14-DEC-2022, entry version 57. DE RecName: Full=VOC domain-containing protein {ECO:0000256|Google:UnProtein}; DE Flags: Fragment; GN Name=Calhm2 {ECO:0000313|MGI:MGI:1919941}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAH96564.1}; RN [1] {ECO:0000313|EMBL:AAH96564.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:AAH96564.1}; RC TISSUE=Mammary gland {ECO:0000313|EMBL:AAH96564.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M., RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the CALHM family. CC {ECO:0000256|ARBA:ARBA00008497}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC096564; AAH96564.1; -; mRNA. DR RefSeq; NP_598507.3; NM_133746.5. DR AlphaFoldDB; Q4VA34; -. DR DNASU; 72691; -. DR GeneID; 72691; -. DR KEGG; mmu:72691; -. DR AGR; MGI:1919941; -. DR CTD; 51063; -. DR MGI; MGI:1919941; Calhm2. DR OrthoDB; 833717at2759; -. DR BioGRID-ORCS; 72691; 1 hit in 71 CRISPR screens. DR ChiTaRS; Calhm2; mouse. DR Genevisible; Q4VA34; MM. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW. DR InterPro; IPR029569; CALHM. DR InterPro; IPR029570; CALHM2. DR PANTHER; PTHR32261; CALCIUM HOMEOSTASIS MODULATOR PROTEIN; 1. DR PANTHER; PTHR32261:SF3; CALCIUM HOMEOSTASIS MODULATOR PROTEIN 2; 1. DR Pfam; PF14798; Ca_hom_mod; 1. PE 2: Evidence at transcript level; KW Ion transport {ECO:0000256|ARBA:ARBA00023065}; KW Membrane {ECO:0000256|ARBA:ARBA00023136}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}; KW Transport {ECO:0000256|ARBA:ARBA00022448}. FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:AAH96564.1" SQ SEQUENCE 224 AA; 25548 MW; CA9E25CD70A38393 CRC64; GTRRHEAPPS AALPLLPGAR RLFFHSLARK FHATVSFSLF SGVKFVCRCL HFICRRLQLS LFVTELKWHD HALLSAVLRP AARLTSLTRS PQFCPLLPPP AHPKCLKHYC SPLSYRQEAY WAQYRTNEDQ LFQRTAEVHS RVLAPNNVRR FFGFVALNKD DEELVAKFPV EGTQPRPQWN AITGVYLYRE NQGLPLYSRL HKWAQGLTGN GTAPDNVEMA LLTA //