ID   CP2U1_RAT               Reviewed;         530 AA.
AC   Q4V8D1;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   05-SEP-2012, entry version 64.
DE   RecName: Full=Cytochrome P450 2U1;
DE            EC=1.14.14.1;
GN   Name=Cyp2u1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=14975754; DOI=10.1016/j.bbrc.2004.01.110;
RA   Karlgren M., Backlund M., Johansson I., Oscarson M.,
RA   Ingelman-Sundberg M.;
RT   "Characterization and tissue distribution of a novel human cytochrome
RT   P450-CYP2U1.";
RL   Biochem. Biophys. Res. Commun. 315:679-685(2004).
CC   -!- FUNCTION: Catalyzes the hydroxylation of arachidonic acid,
CC       docosahexaenoic acid and other long chain fatty acids. May
CC       modulate the arachidonic acid signaling pathway and play a role in
CC       other fatty acid signaling processes (By similarity).
CC   -!- CATALYTIC ACTIVITY: RH + reduced flavoprotein + O(2) = ROH +
CC       oxidized flavoprotein + H(2)O.
CC   -!- COFACTOR: Heme group (By similarity).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass
CC       membrane protein. Microsome membrane.
CC   -!- TISSUE SPECIFICITY: Specifically expressed in thymus and brain. In
CC       brain, expressed in cortex, cerebellum, olfactory bulbs, pons and
CC       medulla and the limbic structures (at protein level).
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family.
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DR   EMBL; BC097442; AAH97442.1; -; mRNA.
DR   IPI; IPI00369186; -.
DR   RefSeq; NP_001019950.1; NM_001024779.1.
DR   UniGene; Rn.161862; -.
DR   HSSP; P10635; 2F9Q.
DR   ProteinModelPortal; Q4V8D1; -.
DR   STRING; Q4V8D1; -.
DR   Ensembl; ENSRNOT00000055570; ENSRNOP00000052433; ENSRNOG00000011053.
DR   GeneID; 310848; -.
DR   KEGG; rno:310848; -.
DR   CTD; 113612; -.
DR   RGD; 1309433; Cyp2u1.
DR   eggNOG; COG2124; -.
DR   GeneTree; ENSGT00670000097960; -.
DR   HOGENOM; HOG000036991; -.
DR   HOVERGEN; HBG015789; -.
DR   InParanoid; Q4V8D1; -.
DR   KO; K07422; -.
DR   OrthoDB; EOG476K02; -.
DR   NextBio; 662741; -.
DR   ArrayExpress; Q4V8D1; -.
DR   Genevestigator; Q4V8D1; -.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005792; C:microsome; IEA:UniProtKB-SubCell.
DR   GO; GO:0070330; F:aromatase activity; IEA:EC.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   Gene3D; G3DSA:1.10.630.10; Cyt_P450; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; Cytochrome_P450; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Endoplasmic reticulum; Heme; Iron; Membrane;
KW   Metal-binding; Microsome; Monooxygenase; NADP; Oxidoreductase;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN         1    530       Cytochrome P450 2U1.
FT                                /FTId=PRO_0000291758.
FT   TRANSMEM     21     41       Helical; (Potential).
FT   TRANSMEM     99    119       Helical; (Potential).
FT   TRANSMEM    247    267       Helical; (Potential).
FT   TRANSMEM    328    348       Helical; (Potential).
FT   TRANSMEM    481    501       Helical; (Potential).
FT   METAL       476    476       Iron (heme axial ligand) (By similarity).
SQ   SEQUENCE   530 AA;  60399 MW;  7BDF8BD34265801A CRC64;
     MSSIGGLRPA AGEQPGVGPH LQAVGGALLL CGLAVLLDWV WLQRQRAGGI PPGPKPRPLV
     GNFGYLLLPR FLRLHFWLGS GSQTDTVGRH VYLARLARVY GNIFSFFIGH RLVVVLSDFQ
     SVREALVQQA EVFSDRPRMP LISILTKEKG IVFAHYGPIW KQQRRFSHST LRHFGLGKLS
     LEPRIIEEFA YVKAEMQKHG EAPFSPFPVI SNAVSNIICS LCFGQRFDYT NKEFKKVLDF
     MSRGLEICLH SQLFLINLCP WFYYLPFGPF KELRQIERDI TCFLKNIIKE HQESLDANNP
     QDFIDMYLLH TQEEKDKCKG TNFDEDYLFY IIGDLFIAGT DTTTNSLLWC LLYMSLNPGV
     QKKVHEEIER VIGRDRAPSL TDKAQMPYTE ATIMEVQRLS MVVPLAIPHM TSEKTVLQGY
     SIPKGTVVLP NLWSIHRDPV IWEKPDDFCP HRFLDDQGQL LKRETFIPFG IGKRVCMGEQ
     LAKMELFLMF VSLMQSFTFA LPEGSEKPIM TGRFGLTLAP HPFNVTVSKR
//