ID Q4U1Z0_MOUSE Unreviewed; 582 AA. AC Q4U1Z0; DT 19-JUL-2005, integrated into UniProtKB/TrEMBL. DT 19-JUL-2005, sequence version 1. DT 11-DEC-2019, entry version 75. DE SubName: Full=Protein tyrosine phosphatase {ECO:0000313|EMBL:CAA86070.1}; DE EC=3.1.3.48 {ECO:0000313|EMBL:CAA86070.1}; DE Flags: Fragment; GN Name=Ptprf {ECO:0000313|MGI:MGI:102695}; GN Synonyms=LAR {ECO:0000313|EMBL:CAA86070.1}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:CAA86070.1}; RN [1] {ECO:0000313|EMBL:CAA86070.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Balb/c {ECO:0000313|EMBL:CAA86070.1}; RC TISSUE=Whole brain {ECO:0000313|EMBL:CAA86070.1}; RA Hendriks W.W.; RL Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:CAA86070.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Balb/c {ECO:0000313|EMBL:CAA86070.1}; RC TISSUE=Whole brain {ECO:0000313|EMBL:CAA86070.1}; RX PubMed=7665159; DOI=10.1006/geno.1995.1014; RA Schaapveld R.Q.L., Van den Maagdenberg A.M.J.M., Schepens J.T.G., RA Weghuis D.O., Van Kessel A.G., Wieringa B., Hendriks W.J.A.J.; RT "The mouse gene Ptprf encoding the leukocyte common antigen-related RT molecule LAR: cloning, characterization, and chromosomal localization."; RL Genomics 27:124-130(1995). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Z37988; CAA86070.1; -; mRNA. DR PeptideAtlas; Q4U1Z0; -. DR MGI; MGI:102695; Ptprf. DR eggNOG; KOG4228; Eukaryota. DR eggNOG; COG5599; LUCA. DR ChiTaRS; Ptprf; mouse. DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC. DR Gene3D; 3.90.190.10; -; 2. DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like. DR InterPro; IPR000242; PTPase_domain. DR InterPro; IPR016130; Tyr_Pase_AS. DR InterPro; IPR003595; Tyr_Pase_cat. DR InterPro; IPR000387; TYR_PHOSPHATASE_dom. DR Pfam; PF00102; Y_phosphatase; 2. DR PRINTS; PR00700; PRTYPHPHTASE. DR SMART; SM00194; PTPc; 2. DR SMART; SM00404; PTPc_motif; 2. DR SUPFAM; SSF52799; SSF52799; 2. DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2. DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2. DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2. PE 2: Evidence at transcript level; KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00160, KW ECO:0000313|EMBL:CAA86070.1}. FT DOMAIN 27..282 FT /note="Tyrosine-protein phosphatase" FT /evidence="ECO:0000259|PROSITE:PS50055" FT DOMAIN 202..273 FT /note="TYR_PHOSPHATASE_2" FT /evidence="ECO:0000259|PROSITE:PS50056" FT DOMAIN 314..573 FT /note="Tyrosine-protein phosphatase" FT /evidence="ECO:0000259|PROSITE:PS50055" FT DOMAIN 491..564 FT /note="TYR_PHOSPHATASE_2" FT /evidence="ECO:0000259|PROSITE:PS50056" FT ACT_SITE 223 FT /note="Phosphocysteine intermediate" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00160" FT ACT_SITE 514 FT /note="Phosphocysteine intermediate" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00160" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:CAA86070.1" SQ SEQUENCE 582 AA; 66965 MW; 933C3C08536342FE CRC64; MRDHPPIPIT DLADNIERLK ANDGLKFSQE YESIDPGQQF TWENSNSEVN KPKNRYANVI AYDHSRVLLT SIDGVPGSDY INANYIDGYR KQNAYIATQG PLPETMGDFW RMVWEQRTAT VVMMTRLEEK SRVKCDQYWP VRGTETYGLI QVTLVDTVEL ATYTMRTFAL HKSGSSEKRE LRQFQFMAWP DHGVPEYPTP ILAFLRRVKA CNPLDAGPMV VHCSAGVGRT GCFIVIDAML ERMKHEKTVD IYGHVTCMRS QRNYMVQTED QYVFIHEALL EAAMCGHTEV LARNLYAHIQ KLGQVPPGES VTAMELEFKL LANSKAHTSR FVSANLPCNK FKNRLVNIMP YELTRVCLQP IRGVEGSDYI NASFLDGYRQ QKAYIATQGP LAESTEDFWR MLWEHNSTII VMLTKLREMG REKCHQYWPA ERSARYQYFV VDPMAEYNMP QYILREFKVT DARDGQSRTI RQFQFTDWPE QGVPKTGEGF IDFIGQVHKT KEQFGQDGPI TVHCSAGVGR TGVFITLSIV LERMRYEGVV DMFQTVKTLR TQRPAMVQTE DQYQLCYRAA LEYLGSFDHY AT //