ID Q4U1Z0_MOUSE Unreviewed; 582 AA. AC Q4U1Z0; DT 19-JUL-2005, integrated into UniProtKB/TrEMBL. DT 19-JUL-2005, sequence version 1. DT 18-JAN-2017, entry version 66. DE SubName: Full=Protein tyrosine phosphatase {ECO:0000313|EMBL:CAA86070.1}; DE EC=3.1.3.48 {ECO:0000313|EMBL:CAA86070.1}; DE Flags: Fragment; GN Name=Ptprf {ECO:0000313|MGI:MGI:102695}; GN Synonyms=LAR {ECO:0000313|EMBL:CAA86070.1}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:CAA86070.1}; RN [1] {ECO:0000313|EMBL:CAA86070.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Balb/c {ECO:0000313|EMBL:CAA86070.1}; RC TISSUE=Whole brain {ECO:0000313|EMBL:CAA86070.1}; RA Hendriks W.W.; RL Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:CAA86070.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Balb/c {ECO:0000313|EMBL:CAA86070.1}; RC TISSUE=Whole brain {ECO:0000313|EMBL:CAA86070.1}; RX PubMed=7665159; DOI=10.1006/geno.1995.1014; RA Schaapveld R.Q.L., Van den Maagdenberg A.M.J.M., Schepens J.T.G., RA Weghuis D.O., Van Kessel A.G., Wieringa B., Hendriks W.J.A.J.; RT "The mouse gene Ptprf encoding the leukocyte common antigen-related RT molecule LAR: cloning, characterization, and chromosomal RT localization."; RL Genomics 27:124-130(1995). CC -!- SIMILARITY: Contains 2 tyrosine-protein phosphatase domain. CC {ECO:0000256|PROSITE-ProRule:PRU00160}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Z37988; CAA86070.1; -; mRNA. DR UniGene; Mm.29855; -. DR ProteinModelPortal; Q4U1Z0; -. DR STRING; 10090.ENSMUSP00000039368; -. DR PaxDb; Q4U1Z0; -. DR PeptideAtlas; Q4U1Z0; -. DR MGI; MGI:102695; Ptprf. DR eggNOG; KOG4228; Eukaryota. DR eggNOG; COG5599; LUCA. DR HOVERGEN; HBG053758; -. DR Bgee; ENSMUSG00000033295; -. DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC. DR Gene3D; 3.90.190.10; -; 2. DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like. DR InterPro; IPR000242; PTPase_domain. DR InterPro; IPR016130; Tyr_Pase_AS. DR InterPro; IPR003595; Tyr_Pase_cat. DR InterPro; IPR000387; TYR_PHOSPHATASE_dom. DR Pfam; PF00102; Y_phosphatase; 2. DR PRINTS; PR00700; PRTYPHPHTASE. DR SMART; SM00194; PTPc; 2. DR SMART; SM00404; PTPc_motif; 2. DR SUPFAM; SSF52799; SSF52799; 2. DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2. DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2. DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2. PE 2: Evidence at transcript level; KW Hydrolase {ECO:0000313|EMBL:CAA86070.1}. FT DOMAIN 27 282 Tyrosine-protein phosphatase. FT {ECO:0000259|PROSITE:PS50055}. FT DOMAIN 202 273 TYR_PHOSPHATASE_2. {ECO:0000259|PROSITE: FT PS50056}. FT DOMAIN 314 573 Tyrosine-protein phosphatase. FT {ECO:0000259|PROSITE:PS50055}. FT DOMAIN 491 564 TYR_PHOSPHATASE_2. {ECO:0000259|PROSITE: FT PS50056}. FT ACT_SITE 223 223 Phosphocysteine intermediate. FT {ECO:0000256|PROSITE-ProRule:PRU00160}. FT ACT_SITE 514 514 Phosphocysteine intermediate. FT {ECO:0000256|PROSITE-ProRule:PRU00160}. FT NON_TER 1 1 {ECO:0000313|EMBL:CAA86070.1}. SQ SEQUENCE 582 AA; 66965 MW; 933C3C08536342FE CRC64; MRDHPPIPIT DLADNIERLK ANDGLKFSQE YESIDPGQQF TWENSNSEVN KPKNRYANVI AYDHSRVLLT SIDGVPGSDY INANYIDGYR KQNAYIATQG PLPETMGDFW RMVWEQRTAT VVMMTRLEEK SRVKCDQYWP VRGTETYGLI QVTLVDTVEL ATYTMRTFAL HKSGSSEKRE LRQFQFMAWP DHGVPEYPTP ILAFLRRVKA CNPLDAGPMV VHCSAGVGRT GCFIVIDAML ERMKHEKTVD IYGHVTCMRS QRNYMVQTED QYVFIHEALL EAAMCGHTEV LARNLYAHIQ KLGQVPPGES VTAMELEFKL LANSKAHTSR FVSANLPCNK FKNRLVNIMP YELTRVCLQP IRGVEGSDYI NASFLDGYRQ QKAYIATQGP LAESTEDFWR MLWEHNSTII VMLTKLREMG REKCHQYWPA ERSARYQYFV VDPMAEYNMP QYILREFKVT DARDGQSRTI RQFQFTDWPE QGVPKTGEGF IDFIGQVHKT KEQFGQDGPI TVHCSAGVGR TGVFITLSIV LERMRYEGVV DMFQTVKTLR TQRPAMVQTE DQYQLCYRAA LEYLGSFDHY AT //