ID Q4U1Z0_MOUSE Unreviewed; 582 AA. AC Q4U1Z0; DT 19-JUL-2005, integrated into UniProtKB/TrEMBL. DT 19-JUL-2005, sequence version 1. DT 11-JUL-2012, entry version 37. DE SubName: Full=Protein tyrosine phosphatase; DE EC=3.1.3.48; DE Flags: Fragment; GN Name=Ptprf; Synonyms=LAR; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Balb/c; TISSUE=Whole brain; RA Hendriks W.W.; RL Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Balb/c; TISSUE=Whole brain; RX MEDLINE=95394448; PubMed=7665159; DOI=10.1006/geno.1995.1014; RA Schaapveld R.Q.L., Van den Maagdenberg A.M.J.M., Schepens J.T.G., RA Weghuis D.O., Van Kessel A.G., Wieringa B., Hendriks W.J.A.J.; RT "The mouse gene Ptprf encoding the leukocyte common antigen-related RT molecule LAR: cloning, characterization, and chromosomal RT localization."; RL Genomics 27:124-130(1995). CC -!- CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein CC tyrosine + phosphate. CC -!- SIMILARITY: Contains 1 tyrosine-protein phosphatase domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Z37988; CAA86070.1; -; mRNA. DR IPI; IPI00647973; -. DR UniGene; Mm.29855; -. DR ProteinModelPortal; Q4U1Z0; -. DR STRING; Q4U1Z0; -. DR PRIDE; Q4U1Z0; -. DR HOVERGEN; HBG053758; -. DR InParanoid; Q4U1Z0; -. DR ArrayExpress; Q4U1Z0; -. DR Bgee; Q4U1Z0; -. DR Genevestigator; Q4U1Z0; -. DR GO; GO:0005768; C:endosome; IEA:Compara. DR GO; GO:0060076; C:excitatory synapse; IEA:Compara. DR GO; GO:0030426; C:growth cone; IEA:Compara. DR GO; GO:0005792; C:microsome; IEA:Compara. DR GO; GO:0043025; C:neuronal cell body; IEA:Compara. DR GO; GO:0005886; C:plasma membrane; IEA:Compara. DR GO; GO:0042301; F:phosphate ion binding; IEA:Compara. DR GO; GO:0005001; F:transmembrane receptor protein tyrosine phosphatase activity; IEA:Compara. DR GO; GO:0007156; P:homophilic cell adhesion; IEA:Compara. DR GO; GO:0031345; P:negative regulation of cell projection organization; IEA:Compara. DR GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Compara. DR GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:Compara. DR GO; GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; IEA:Compara. DR GO; GO:0046627; P:negative regulation of insulin receptor signaling pathway; IEA:Compara. DR GO; GO:0051387; P:negative regulation of nerve growth factor receptor signaling pathway; IEA:Compara. DR GO; GO:0050775; P:positive regulation of dendrite morphogenesis; IEA:Compara. DR GO; GO:0043525; P:positive regulation of neuron apoptotic process; IEA:Compara. DR GO; GO:0050803; P:regulation of synapse structure and activity; IEA:Compara. DR InterPro; IPR000387; Tyr/Dual-specificity_Pase. DR InterPro; IPR016130; Tyr_Pase_AS. DR InterPro; IPR000242; Tyr_Pase_rcpt/non-rcpt. DR Pfam; PF00102; Y_phosphatase; 2. DR PRINTS; PR00700; PRTYPHPHTASE. DR SMART; SM00194; PTPc; 2. DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2. DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2. DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2. PE 2: Evidence at transcript level; KW Hydrolase; Protein phosphatase. FT NON_TER 1 1 SQ SEQUENCE 582 AA; 66965 MW; 933C3C08536342FE CRC64; MRDHPPIPIT DLADNIERLK ANDGLKFSQE YESIDPGQQF TWENSNSEVN KPKNRYANVI AYDHSRVLLT SIDGVPGSDY INANYIDGYR KQNAYIATQG PLPETMGDFW RMVWEQRTAT VVMMTRLEEK SRVKCDQYWP VRGTETYGLI QVTLVDTVEL ATYTMRTFAL HKSGSSEKRE LRQFQFMAWP DHGVPEYPTP ILAFLRRVKA CNPLDAGPMV VHCSAGVGRT GCFIVIDAML ERMKHEKTVD IYGHVTCMRS QRNYMVQTED QYVFIHEALL EAAMCGHTEV LARNLYAHIQ KLGQVPPGES VTAMELEFKL LANSKAHTSR FVSANLPCNK FKNRLVNIMP YELTRVCLQP IRGVEGSDYI NASFLDGYRQ QKAYIATQGP LAESTEDFWR MLWEHNSTII VMLTKLREMG REKCHQYWPA ERSARYQYFV VDPMAEYNMP QYILREFKVT DARDGQSRTI RQFQFTDWPE QGVPKTGEGF IDFIGQVHKT KEQFGQDGPI TVHCSAGVGR TGVFITLSIV LERMRYEGVV DMFQTVKTLR TQRPAMVQTE DQYQLCYRAA LEYLGSFDHY AT //