ID Q4U1Z0_MOUSE Unreviewed; 582 AA. AC Q4U1Z0; DT 19-JUL-2005, integrated into UniProtKB/TrEMBL. DT 19-JUL-2005, sequence version 1. DT 19-JAN-2010, entry version 24. DE SubName: Full=Protein tyrosine phosphatase; DE EC=3.1.3.48; DE Flags: Fragment; GN Name=Ptprf; Synonyms=LAR; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Balb/c; TISSUE=Whole brain; RX MEDLINE=95394448; PubMed=7665159; DOI=10.1006/geno.1995.1014; RA Schaapveld R.Q.L., Van den Maagdenberg A.M.J.M., Schepens J.T.G., RA Weghuis D.O., Van Kessel A.G., Wieringa B., Hendriks W.J.A.J.; RT "The mouse gene Ptprf encoding the leukocyte common antigen-related RT molecule LAR: cloning, characterization, and chromosomal RT localization."; RL Genomics 27:124-130(1995). RN [2] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Balb/c; TISSUE=Whole brain; RA Hendriks W.W.; RL Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Z37988; CAA86070.1; -; mRNA. DR IPI; IPI00647973; -. DR UniGene; Mm.29855; -. DR SMR; Q4U1Z0; 9-577. DR STRING; Q4U1Z0; -. DR PRIDE; Q4U1Z0; -. DR Ensembl; ENSMUST00000049074; ENSMUSP00000039368; ENSMUSG00000033295; Mus musculus. DR Ensembl; ENSMUST00000106394; ENSMUSP00000102002; ENSMUSG00000033295; Mus musculus. DR MGI; MGI:102695; Ptprf. DR HOVERGEN; Q4U1Z0; -. DR InParanoid; Q4U1Z0; -. DR PhylomeDB; Q4U1Z0; -. DR ArrayExpress; Q4U1Z0; -. DR Bgee; Q4U1Z0; -. DR Genevestigator; Q4U1Z0; -. DR GO; GO:0043025; C:cell soma; IEA:Compara. DR GO; GO:0005768; C:endosome; IEA:Compara. DR GO; GO:0060076; C:excitatory synapse; IEA:Compara. DR GO; GO:0030426; C:growth cone; IEA:Compara. DR GO; GO:0005792; C:microsome; IEA:Compara. DR GO; GO:0005886; C:plasma membrane; IEA:Compara. DR GO; GO:0005158; F:insulin receptor binding; IEA:Compara. DR GO; GO:0042301; F:phosphate binding; IEA:Compara. DR GO; GO:0030971; F:receptor tyrosine kinase binding; IEA:Compara. DR GO; GO:0005001; F:transmembrane receptor protein tyrosine pho...; IEA:Compara. DR GO; GO:0007156; P:homophilic cell adhesion; IEA:Compara. DR GO; GO:0031345; P:negative regulation of cell projection orga...; IEA:Compara. DR GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Compara. DR GO; GO:0001960; P:negative regulation of cytokine-mediated si...; IEA:Compara. DR GO; GO:0042059; P:negative regulation of epidermal growth fac...; IEA:Compara. DR GO; GO:0046627; P:negative regulation of insulin receptor sig...; IEA:Compara. DR GO; GO:0051387; P:negative regulation of nerve growth factor ...; IEA:Compara. DR GO; GO:0050775; P:positive regulation of dendrite morphogenesis; IEA:Compara. DR GO; GO:0043525; P:positive regulation of neuron apoptosis; IEA:Compara. DR GO; GO:0006470; P:protein amino acid dephosphorylation; IEA:InterPro. DR GO; GO:0050803; P:regulation of synapse structure and activity; IEA:Compara. DR InterPro; IPR000387; Dual-sp/Tyr_phosphatase. DR InterPro; IPR016130; Tyr_Pase_AS. DR InterPro; IPR000242; Tyr_Pase_rcpt/non-rcpt. DR Pfam; PF00102; Y_phosphatase; 2. DR PRINTS; PR00700; PRTYPHPHTASE. DR SMART; SM00194; PTPc; 2. DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2. DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2. DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2. PE 2: Evidence at transcript level; KW Hydrolase. FT NON_TER 1 1 SQ SEQUENCE 582 AA; 66965 MW; 933C3C08536342FE CRC64; MRDHPPIPIT DLADNIERLK ANDGLKFSQE YESIDPGQQF TWENSNSEVN KPKNRYANVI AYDHSRVLLT SIDGVPGSDY INANYIDGYR KQNAYIATQG PLPETMGDFW RMVWEQRTAT VVMMTRLEEK SRVKCDQYWP VRGTETYGLI QVTLVDTVEL ATYTMRTFAL HKSGSSEKRE LRQFQFMAWP DHGVPEYPTP ILAFLRRVKA CNPLDAGPMV VHCSAGVGRT GCFIVIDAML ERMKHEKTVD IYGHVTCMRS QRNYMVQTED QYVFIHEALL EAAMCGHTEV LARNLYAHIQ KLGQVPPGES VTAMELEFKL LANSKAHTSR FVSANLPCNK FKNRLVNIMP YELTRVCLQP IRGVEGSDYI NASFLDGYRQ QKAYIATQGP LAESTEDFWR MLWEHNSTII VMLTKLREMG REKCHQYWPA ERSARYQYFV VDPMAEYNMP QYILREFKVT DARDGQSRTI RQFQFTDWPE QGVPKTGEGF IDFIGQVHKT KEQFGQDGPI TVHCSAGVGR TGVFITLSIV LERMRYEGVV DMFQTVKTLR TQRPAMVQTE DQYQLCYRAA LEYLGSFDHY AT //