ID Q4SPP3_TETNG Unreviewed; 685 AA. AC Q4SPP3; DT 19-JUL-2005, integrated into UniProtKB/TrEMBL. DT 19-JUL-2005, sequence version 1. DT 24-JUL-2024, entry version 62. DE RecName: Full=Major facilitator superfamily domain-containing protein 1 {ECO:0000256|ARBA:ARBA00040619}; GN ORFNames=GSTENG00014734001 {ECO:0000313|EMBL:CAF97389.1}; OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon OS nigroviridis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon. OX NCBI_TaxID=99883 {ECO:0000313|EMBL:CAF97389.1}; RN [1] {ECO:0000313|EMBL:CAF97389.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15496914; DOI=10.1038/nature03025; RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N., RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S., RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C., RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C., RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L., RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P., RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C., RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R., RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W., RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.; RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the RT early vertebrate proto-karyotype."; RL Nature 431:946-957(2004). RN [2] {ECO:0000313|EMBL:CAF97389.1} RP NUCLEOTIDE SEQUENCE. RG Genoscope; RG Whitehead Institute Centre for Genome Research; RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Lysosome membrane CC {ECO:0000256|ARBA:ARBA00004155}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004155}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the major facilitator superfamily. CC {ECO:0000256|ARBA:ARBA00008335}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:CAF97389.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CAAE01014537; CAF97389.1; -; Genomic_DNA. DR AlphaFoldDB; Q4SPP3; -. DR KEGG; tng:GSTEN00014734G001; -. DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell. DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro. DR CDD; cd17340; MFS_MFSD1; 1. DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 3. DR InterPro; IPR011701; MFS. DR InterPro; IPR020846; MFS_dom. DR InterPro; IPR036259; MFS_trans_sf. DR InterPro; IPR052187; MFSD1. DR PANTHER; PTHR23512; MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1; 1. DR PANTHER; PTHR23512:SF3; MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1; 1. DR Pfam; PF07690; MFS_1; 2. DR SUPFAM; SSF103473; MFS general substrate transporter; 2. DR PROSITE; PS50850; MFS; 1. PE 3: Inferred from homology; KW Lysosome {ECO:0000256|ARBA:ARBA00023228}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}. FT TRANSMEM 12..31 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 52..74 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 80..104 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 180..206 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 237..263 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 275..295 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 301..321 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 328..350 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 474..495 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 516..538 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 544..564 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 571..591 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 603..625 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 632..657 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 663..682 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 13..432 FT /note="Major facilitator superfamily (MFS) profile" FT /evidence="ECO:0000259|PROSITE:PS50850" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:CAF97389.1" SQ SEQUENCE 685 AA; 75213 MW; DA15716B4DE6D6AF CRC64; LRAICDPNHL SHRVVVLAFM CFLGFGSYFC FDNPAALQTQ VIKDLDLNTA KFMQLYAWYS WPNVVLCFFG GFLIDRVFGI RLGTIIFSLF VCVGQVIFAT GALVNRFWLC EVGRFVFGIG GESLAVAQNT YAVNWFKGKE LNLVFGLQLS MARLGSTVNM NIMGSVYSRI TDLVGSPGHF TLGISLMIGG LPCLFSLLCA LVLGFLDRRA EKILHKEEGK TGEVIKLTDV KDFPLPLWLI FIICVGYYVA IFPFIGLGQV FFIEKFNFSP AEARAVNSIV YIISAPASPV LGFLVDKTGR NVIWVLIAVV TTLAAHMMLA FTFWNPWIAM SVLGASYSLL ACVLLPMVAF VVPEHQVGTA YGFMQSIQNL GLALIAMAAG TILDTRGYLI LEVDSAKLTP MSAFGLRNRY LSRLGAQISM PMFFLFLHSA STPLLHPSVI TCPQERPEVK PLRRHSALCL GTTEDLDLST AEFMVLYSCY AWPNVVLCFF GGFLIDRVFG IRVFFIEKFN FSLAEARAVN SIVYLISAPA SLVLGFLVNK TGRNVIWVLI AVVTTLAAHM MLAFTFWNPW IAMSVLGASC SVVACVLWPM VAFVVPEHQL GTAYGFMQSI QNLGLALIAM AAGTILDTRG YLILEVFFCT CVCSECFCVC VSVLVLLGLW MTSGFFCLSF LDGGGGAVLC GLSQR //