ID Q4PMB2_IXOSC Unreviewed; 299 AA. AC Q4PMB2; DT 19-JUL-2005, integrated into UniProtKB/TrEMBL. DT 19-JUL-2005, sequence version 1. DT 02-OCT-2024, entry version 80. DE RecName: Full=ADP/ATP translocase {ECO:0000256|RuleBase:RU368008}; DE AltName: Full=ADP,ATP carrier protein {ECO:0000256|RuleBase:RU368008}; OS Ixodes scapularis (Black-legged tick) (Deer tick). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari; OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes. OX NCBI_TaxID=6945 {ECO:0000313|EMBL:AAY66852.1}; RN [1] {ECO:0000313|EMBL:AAY66852.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=ISUFL14 {ECO:0000313|EMBL:AAY66852.1}; RC TISSUE=Salivary glands {ECO:0000313|EMBL:AAY66852.1}; RA Tseng H.-P., Hseu T.-H., Buhler D.R., Wang W.-D., Tsai H.-L., Hu C.-H.; RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:AAY66852.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=ISUFL14 {ECO:0000313|EMBL:AAY66852.1}; RC TISSUE=Salivary glands {ECO:0000313|EMBL:AAY66852.1}; RX PubMed=16431279; DOI=10.1016/j.ibmb.2005.11.005; RA Ribeiro J.M., Alarcon-Chaidez F., Francischetti I.M., Mans B.J., RA Mather T.N., Valenzuela J.G., Wikel S.K.; RT "An annotated catalog of salivary gland transcripts from Ixodes scapularis RT ticks."; RL Insect Biochem. Mol. Biol. 36:111-129(2006). CC -!- FUNCTION: Catalyzes the exchange of ADP and ATP across the membrane. CC {ECO:0000256|RuleBase:RU368008}. CC -!- CATALYTIC ACTIVITY: CC Reaction=ADP(in) + ATP(out) = ADP(out) + ATP(in); Xref=Rhea:RHEA:34999, CC ChEBI:CHEBI:30616, ChEBI:CHEBI:456216; CC Evidence={ECO:0000256|ARBA:ARBA00024143}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35000; CC Evidence={ECO:0000256|ARBA:ARBA00024143}; CC -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245, CC ECO:0000256|RuleBase:RU368008}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141, CC ECO:0000256|RuleBase:RU368008}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU368008}. CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family. CC {ECO:0000256|ARBA:ARBA00006375, ECO:0000256|RuleBase:RU000488}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|RuleBase:RU368008}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ066215; AAY66852.1; -; mRNA. DR AlphaFoldDB; Q4PMB2; -. DR VEuPathDB; VectorBase:ISCI021754; -. DR VEuPathDB; VectorBase:ISCP_034888; -. DR VEuPathDB; VectorBase:ISCW021754; -. DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:InterPro. DR GO; GO:0005471; F:ATP:ADP antiporter activity; IEA:UniProtKB-UniRule. DR GO; GO:0140021; P:mitochondrial ADP transmembrane transport; IEA:InterPro. DR GO; GO:1990544; P:mitochondrial ATP transmembrane transport; IEA:InterPro. DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1. DR InterPro; IPR002113; ADT_euk_type. DR InterPro; IPR002067; Mit_carrier. DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier. DR InterPro; IPR023395; Mt_carrier_dom_sf. DR PANTHER; PTHR45635; ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED; 1. DR PANTHER; PTHR45635:SF14; ADP,ATP CARRIER PROTEIN-RELATED; 1. DR Pfam; PF00153; Mito_carr; 3. DR PRINTS; PR00927; ADPTRNSLCASE. DR PRINTS; PR00926; MITOCARRIER. DR SUPFAM; SSF103506; Mitochondrial carrier; 1. DR PROSITE; PS50920; SOLCAR; 3. PE 2: Evidence at transcript level; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE- KW ProRule:PRU00282}; Repeat {ECO:0000256|ARBA:ARBA00022737}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE- KW ProRule:PRU00282}; Transmembrane helix {ECO:0000256|RuleBase:RU368008}; KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000488}. FT TRANSMEM 173..191 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU368008" FT TRANSMEM 211..231 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU368008" FT REPEAT 6..98 FT /note="Solcar" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282" FT REPEAT 111..201 FT /note="Solcar" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282" FT REPEAT 212..297 FT /note="Solcar" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282" SQ SEQUENCE 299 AA; 32907 MW; 1A68398B537217D3 CRC64; MSFDPISFAK DFIAGGVAAA ISKTAVAPIE RVKLLLQVQH ASTQISEAQR YKGMVDCFVR IPREQGFLSF WRGNLANVIR YFPTQALNFA FKDKYKQVFL GGVDKKTQFW RYFAGNLASG GAAGATSLCF VYPLDFARTR LAADIGKGAG QREFSGLGNC LTKIFKSDGL MGLYRGFGVS VQGIIIYRAA YFGFFDTAKG MLPDPKNTPL VISWLIAQTV TTVAGIMSYP FDTVRRRMMM QSGRAKADLM YKSTAHCWGK IYKTEGGAAF FKGAFSNVLR GTGGSLVLVL YDEIKAFIF //