ID Q4LE69_HUMAN Unreviewed; 2121 AA. AC Q4LE69; DT 02-AUG-2005, integrated into UniProtKB/TrEMBL. DT 02-AUG-2005, sequence version 1. DT 08-MAY-2019, entry version 98. DE SubName: Full=PIK4CA variant protein {ECO:0000313|EMBL:BAE06084.1}; DE Flags: Fragment; GN Name=PIK4CA variant protein {ECO:0000313|EMBL:BAE06084.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAE06084.1}; RN [1] {ECO:0000313|EMBL:BAE06084.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Brain {ECO:0000313|EMBL:BAE06084.1}; RA Nakajima D., Saito K., Yamakawa H., Kikuno R.F., Nakayama M., RA Ohara R., Okazaki N., Koga H., Nagase T., Ohara O.; RT "Preparation of a set of expression-ready clones of mammalian long RT cDNAs encoding large proteins by the ORF trap cloning method."; RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. CC {ECO:0000256|SAAS:SAAS01097356}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB210002; BAE06084.1; -; mRNA. DR RefSeq; NP_477352.3; NM_058004.3. DR PRIDE; Q4LE69; -. DR GeneID; 5297; -. DR KEGG; hsa:5297; -. DR CTD; 5297; -. DR PharmGKB; PA162399305; -. DR eggNOG; KOG0902; Eukaryota. DR eggNOG; COG5032; LUCA. DR HOGENOM; HOG000007272; -. DR KO; K00888; -. DR OrthoDB; 1147978at2759; -. DR ChiTaRS; PI4KA; human. DR GenomeRNAi; 5297; -. DR Genevisible; Q4LE69; HS. DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-UniRule. DR GO; GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro. DR GO; GO:0048015; P:phosphatidylinositol-mediated signaling; IEA:InterPro. DR Gene3D; 1.10.1070.11; -; 1. DR InterPro; IPR016024; ARM-type_fold. DR InterPro; IPR011009; Kinase-like_dom_sf. DR InterPro; IPR000403; PI3/4_kinase_cat_dom. DR InterPro; IPR036940; PI3/4_kinase_cat_sf. DR InterPro; IPR018936; PI3/4_kinase_CS. DR InterPro; IPR015433; PI_Kinase. DR InterPro; IPR001263; PInositide-3_kin_accessory_dom. DR PANTHER; PTHR10048; PTHR10048; 1. DR Pfam; PF00454; PI3_PI4_kinase; 1. DR Pfam; PF00613; PI3Ka; 1. DR SMART; SM00145; PI3Ka; 1. DR SMART; SM00146; PI3Kc; 1. DR SUPFAM; SSF48371; SSF48371; 2. DR SUPFAM; SSF56112; SSF56112; 1. DR PROSITE; PS00915; PI3_4_KINASE_1; 1. DR PROSITE; PS00916; PI3_4_KINASE_2; 1. DR PROSITE; PS50290; PI3_4_KINASE_3; 1. DR PROSITE; PS51545; PIK_HELICAL; 1. PE 2: Evidence at transcript level; KW Kinase {ECO:0000256|PROSITE-ProRule:PRU00269, KW ECO:0000256|SAAS:SAAS00977381}; KW Transferase {ECO:0000256|PROSITE-ProRule:PRU00269, KW ECO:0000256|SAAS:SAAS00977438}. FT DOMAIN 1549 1737 PIK helical. {ECO:0000259|PROSITE: FT PS51545}. FT DOMAIN 1864 2121 PI3K/PI4K. {ECO:0000259|PROSITE:PS50290}. FT NON_TER 1 1 {ECO:0000313|EMBL:BAE06084.1}. SQ SEQUENCE 2121 AA; 238697 MW; 5B3CEC2D4645DFB6 CRC64; GRSRARSGEP AGSAAAREVM AAAPARGGGG GGGGGGGCSG SGSSASRGFY FNTVLSLARS LAVQRPASLE KVQKLLCMCP VDFHGIFQLD ERRRDAVIAL GIFLIESDLQ HKDCVVPYLL RLLKGLPKVY WVEESTARKG RGALPVAESF SFCLVTLLSD VAYRDPSLRD EILEVLLQVL HVLLGMCQAL EIQDKEYLCK YAIPCLIGIS RAFGRYSNME ESLLSKLFPK IPPHSLRVLE ELEGVRRRSF NDFRSILPSN LLTVCQEGTL KRKTSSVSSI SQVSPERGMP PPSSPGGSAF HYFEASCLPD GTALEPEYYF STISSSFSVS PLFNGVTYKE FNIPLEMLRE LLNLVKKIVE EAVLKSLDAI VASVMEANPS ADLYYTSFSD PLYLTMFKML RDTLYYMKDL PTSFVKEIHD FVLEQFNTSQ GELQKILHDA DRIHNELSPL KLRCQANAAC VDLMVWAVKD EQGAENLCIK LSEKLQSKTS SKVIIAHLPL LICCLQGLGR LCERFPVVVH SVTPSLRDFL VIPSPVLVKL YKYHSQYHTV AGNDIKISVT NEHSESTLNV MSGKKSQPSM YEQLRDIAID NICRCLKAGL TVDPVIVEAF LASLSNRLYI SQESDKDAHL IPDHTIRALG HIAVALRDTP KVMEPILQIL QQKFCQPPSP LDVLIIDQLG CLVITGNQYI YQEVWNLFQQ ISVKASSVVY SATKDYKDHG YRHCSLAVIN ALANIAANIQ DEHLVDELLM NLLELFVQLG LEGKRASERA SEKGPALKAS SSAGNLGVLI PVIAVLTRRL PPIKEAKPRL QKLFRDFWLY SVLMGFAVEG SGLWPEEWYE GVCEIATKSP LLTFPSKEPL RSVLQYNSAM KNDTVTPAEL SELRSTIINL LDPPPEVSAL INKLDFAMST YLLSVYRLEY MRVLRSTDPD RFQVMFCYFE DKAIQKDKSG MMQCVIAVAD KVFDAFLNMM ADKAKTKENE EELERHAQFL LVNFNHIHKR IRRVADKYLS GLVDKFPHLL WSGTVLKTML DILQTLSLSL SADIHKDQPY YDIPDAPYRI TVPDTYEARE SIVKDFAARC GMILQEAMKW APTVTKSHLQ EYLNKHQNWV SGLSQHTGLA MATESILHFA GYNKQNTTLG ATQLSERPAC VKKDYSNFMA SLNLRNRYAG EVYGMIRFSG TTGQMSDLNK MMVQDLHSAL DRSHPQHYTQ AMFKLTAMLI SSKDCDPQLL HHLCWGPLRM FNEHGMETAL ACWEWLLAGK DGVEVPFMRE MAGAWHMTVE QKFGLFSAEI KEADPLAASE ASQPKPCPPE VTPHYIWIDF LVQRFEIAKY CSSDQVEIFS SLLQRSMSLN IGGAKGSMNR HVAAIGPRFK LLTLGLSLLH ADVVPNATIR NVLREKIYST AFDYFSCPPK FPTQGEKRLR EDISIMIKFW TAMFSDKKYL TASQLVPPDN QDTRSNLDIT VGSRQQATQG WINTYPLSSG MSTISKKSGM SKKTNRGSQL HKYYMKRRTL LLSLLATEIE RLITWYNPLS APELELDQAG ENSVANWRSK YISLSEKQWK DNVNLAWSIS PYLAVQLPAR FKNTEAIGNE VTRLVRLDPG AVSDVPEAIK FLVTWHTIDA DAPELSHVLC WAPTDPPTGL SYFSSMYPPH PLTAQYGVKV LRSFPPDAIL FYIPQIVQAL RYDKMGYVRE YILWAASKSQ LLAHQFIWNM KTNIYLDEEG HQKDPDIGDL LDQLVEEITG SLSGPAKDFY QREFDFFNKI TNVSAIIKPY PKGDERKKAC LSALSEVKVQ PGCYLPSNPE AIVLDIDYKS GTPMQSAAKA PYLAKFKVKR CGVSELEKEG LRCRSDSEDE CSTQEADGQK ISWQAAIFKV GDDCRQDMLA LQIIDLFKNI FQLVGLDLFV FPYRVVATAP GCGVIECIPD CTSRDQLGRQ TDFGMYDYFT RQYGDESTLA FQQARYNFIR SMAAYSLLLF LLQIKDRHNG NIMLDKKGHI IHIDFGFMFE SSPGGNLGWE PDIKLTDEMV MIMGGKMEAT PFKWFMEMCV RGYLAVRPYM DAVVSLVTLM LDTGLPCFRG QTIKLLKHRF SPNMTEREAA NFIMKVIQSC FLSNRSRTYD MIQYYQNDIP Y //