ID   Q4KNF6_CERNE            Unreviewed;       212 AA.
AC   Q4KNF6;
DT   02-AUG-2005, integrated into UniProtKB/TrEMBL.
DT   02-AUG-2005, sequence version 1.
DT   08-APR-2008, entry version 20.
DE   Cytochrome c oxidase subunit 1 (EC 1.9.3.1) (Fragment).
GN   Name=COXI;
OS   Cercopithecus neglectus (Debrazza's monkey).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Cercopithecus.
OX   NCBI_TaxID=36227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PR00981; TISSUE=Blood;
RX   PubMed=16214744; DOI=10.1098/rstb.2005.1718;
RA   Lorenz J.G., Jackson W.E., Beck J.C., Hanner R.;
RT   "The problems and promise of DNA barcodes for species diagnosis of
RT   primate biomaterials.";
RL   Philos. Trans. R. Soc. Lond., B, Biol. Sci. 360:1869-1877(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PR00981; TISSUE=Blood;
RA   Lorenz J.G., Jackson W.E., Beck J.C., Hanner R.;
RT   "'Molecular Barcoding' of the Order Primates: Practical Applications
RT   and Theoretical Concerns.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory
CC       chain that catalyzes the reduction of oxygen to water. Subunits 1-
CC       3 form the functional core of the enzyme complex. CO I is the
CC       catalytic subunit of the enzyme. Electrons originating in
CC       cytochrome c are transferred via the copper A center of subunit 2
CC       and heme A of subunit 1 to the bimetallic center formed by heme A3
CC       and copper B (By similarity).
CC   -!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) + 4 H(+) = 4
CC       ferricytochrome c + 2 H(2)O.
CC   -!- PATHWAY: Energy metabolism; oxidative phosphorylation.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass
CC       membrane protein (By similarity).
CC   -!- SIMILARITY: Belongs to the heme-copper respiratory oxidase family.
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DR   EMBL; AY972783; AAY22349.1; -; Genomic_DNA.
DR   SMR; Q4KNF6; 1-212.
DR   GO; GO:0016021; C:integral to membrane; IEA:InterPro.
DR   GO; GO:0005746; C:mitochondrial respiratory chain; IEA:UniProtKB-KW.
DR   GO; GO:0005507; F:copper ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:EC.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0009060; P:aerobic respiration; IEA:InterPro.
DR   GO; GO:0006118; P:electron transport; IEA:InterPro.
DR   GO; GO:0006810; P:transport; IEA:UniProtKB-KW.
DR   InterPro; IPR000883; COX1.
DR   Gene3D; G3DSA:1.20.210.10; COX1; 1.
DR   PANTHER; PTHR10422; COX1; 1.
DR   Pfam; PF00115; COX1; 1.
DR   PRINTS; PR01165; CYCOXIDASEI.
DR   PROSITE; PS50855; COX1; 1.
PE   3: Inferred from homology;
KW   Copper; Electron transport; Heme; Inner membrane; Membrane;
KW   Mitochondrion; Oxidoreductase; Respiratory chain; Transmembrane;
KW   Transport.
FT   NON_TER       1      1
FT   NON_TER     212    212
SQ   SEQUENCE   212 AA;  22620 MW;  ABDBC12852007B9F CRC64;
     LLFGAWAGIM GTALSLLIRA ELGQPGSLLG SDHIYNVIVT AHAFIMIFFM VMPIMIGGFG
     NWLVPLMIGA PDMAFPRLNN MSFWLLPPSF LLLMASAMVE AGAGTGWTVY PPLAGNLSHP
     GASVDLVIFS LHLAGVSSIL GAINFITTII NMKPPAMSQY QTPLFVWSVL ITAILLLLSL
     PVLAAGITML LTDRNLNTTF FDPTGGGDPI LY
//