ID   Q4KMJ7_DANRE            Unreviewed;       263 AA.
AC   Q4KMJ7;
DT   02-AUG-2005, integrated into UniProtKB/TrEMBL.
DT   02-AUG-2005, sequence version 1.
DT   07-APR-2021, entry version 88.
DE   SubName: Full=Mip2 protein {ECO:0000313|EMBL:AAH98535.1};
GN   Name=mipb {ECO:0000313|ZFIN:ZDB-GENE-050706-86};
GN   Synonyms=mip2 {ECO:0000313|EMBL:AAH98535.1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH98535.1};
RN   [1] {ECO:0000313|EMBL:AAH98535.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye {ECO:0000313|EMBL:AAH98535.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family.
CC       {ECO:0000256|ARBA:ARBA00006175, ECO:0000256|RuleBase:RU000477}.
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DR   EMBL; BC098535; AAH98535.1; -; mRNA.
DR   ZFIN; ZDB-GENE-050706-86; mipb.
DR   OMA; HLMGMYY; -.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0015267; F:channel activity; IEA:InterPro.
DR   GO; GO:0005372; F:water transmembrane transporter activity; IDA:ZFIN.
DR   GO; GO:0002088; P:lens development in camera-type eye; IMP:ZFIN.
DR   GO; GO:0070309; P:lens fiber cell morphogenesis; IGI:ZFIN.
DR   GO; GO:0006833; P:water transport; IBA:GO_Central.
DR   CDD; cd00333; MIP; 1.
DR   Gene3D; 1.20.1080.10; -; 1.
DR   InterPro; IPR023271; Aquaporin-like.
DR   InterPro; IPR034294; Aquaporin_transptr.
DR   InterPro; IPR000425; MIP.
DR   InterPro; IPR022357; MIP_CS.
DR   PANTHER; PTHR19139; PTHR19139; 1.
DR   Pfam; PF00230; MIP; 1.
DR   PRINTS; PR00783; MINTRINSICP.
DR   SUPFAM; SSF81338; SSF81338; 1.
DR   TIGRFAMs; TIGR00861; MIP; 1.
DR   PROSITE; PS00221; MIP; 1.
PE   2: Evidence at transcript level;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000477};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000477}.
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        38..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        86..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        127..148
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        160..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        202..224
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          238..263
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   263 AA;  29028 MW;  26E7B87B233C3263 CRC64;
     MWEFRSMMFW RAVFAEFFST MFFVFFGMGA ALRWTTGPYH VFHTALCFGF AAATLIQSIG
     HISGGHINPA VTFAYLVGSQ MSVFRAFFYI CAQCLGAMAG AAALYGVTPN NMRGTMALNT
     LQPGMSLGMA TTVEVFLTMQ LVVCVFAVTD ERRNGRLGSA ALSIGFSVTM GHLMGMYYTG
     AGMNPARSFA PAVITRNFIN HWVYWVGPMI GAAMGAIFYD FFLFPRMRGF SERLATLKGS
     RPPEAENQQE TRGEPIELKT QTL
//