ID Q4JBG1_SULAC Unreviewed; 409 AA. AC Q4JBG1; DT 02-AUG-2005, integrated into UniProtKB/TrEMBL. DT 02-AUG-2005, sequence version 1. DT 16-JAN-2019, entry version 69. DE RecName: Full=Coenzyme A biosynthesis bifunctional protein CoaBC {ECO:0000256|RuleBase:RU364078}; DE EC=4.1.1.36 {ECO:0000256|RuleBase:RU364078}; DE EC=6.3.2.5 {ECO:0000256|RuleBase:RU364078}; DE AltName: Full=DNA/pantothenate metabolism flavoprotein {ECO:0000256|RuleBase:RU364078}; GN OrderedLocusNames=Saci_0458 {ECO:0000313|EMBL:AAY79868.1}; OS Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / OS NBRC 15157 / NCIMB 11770). OC Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae; OC Sulfolobus. OX NCBI_TaxID=330779 {ECO:0000313|EMBL:AAY79868.1, ECO:0000313|Proteomes:UP000001018}; RN [1] {ECO:0000313|EMBL:AAY79868.1, ECO:0000313|Proteomes:UP000001018} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770 RC {ECO:0000313|Proteomes:UP000001018}; RX PubMed=15995215; DOI=10.1128/JB.187.14.4992-4999.2005; RA Chen L., Brugger K., Skovgaard M., Redder P., She Q., Torarinsson E., RA Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.; RT "The genome of Sulfolobus acidocaldarius, a model organism of the RT Crenarchaeota."; RL J. Bacteriol. 187:4992-4999(2005). CC -!- FUNCTION: Catalyzes two steps in the biosynthesis of coenzyme A. CC In the first step cysteine is conjugated to 4'-phosphopantothenate CC to form 4-phosphopantothenoylcysteine, in the latter compound is CC decarboxylated to form 4'-phosphopantotheine. CC {ECO:0000256|RuleBase:RU364078}. CC -!- CATALYTIC ACTIVITY: CC Reaction=(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + CC diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine; CC Xref=Rhea:RHEA:19397, ChEBI:CHEBI:10986, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:33019, ChEBI:CHEBI:35235, ChEBI:CHEBI:37563, CC ChEBI:CHEBI:59458, ChEBI:CHEBI:60377; EC=6.3.2.5; CC Evidence={ECO:0000256|RuleBase:RU364078}; CC -!- CATALYTIC ACTIVITY: CC Reaction=H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = CO2 + CC D-pantetheine 4'-phosphate; Xref=Rhea:RHEA:16793, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:59458, CC ChEBI:CHEBI:61723; EC=4.1.1.36; CC Evidence={ECO:0000256|RuleBase:RU364078}; CC -!- COFACTOR: CC Name=FMN; Xref=ChEBI:CHEBI:58210; CC Evidence={ECO:0000256|RuleBase:RU364078}; CC -!- PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from CC (R)-pantothenate: step 2/5. {ECO:0000256|RuleBase:RU364078}. CC -!- PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from CC (R)-pantothenate: step 3/5. {ECO:0000256|RuleBase:RU364078}. CC -!- SIMILARITY: In the C-terminal section; belongs to the PPC CC synthetase family. {ECO:0000256|RuleBase:RU364078}. CC -!- SIMILARITY: In the N-terminal section; belongs to the HFCD (homo- CC oligomeric flavin containing Cys decarboxylase) superfamily. CC {ECO:0000256|RuleBase:RU364078}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP000077; AAY79868.1; -; Genomic_DNA. DR RefSeq; WP_011277370.1; NC_007181.1. DR ProteinModelPortal; Q4JBG1; -. DR STRING; 330779.Saci_0458; -. DR EnsemblBacteria; AAY79868; AAY79868; Saci_0458. DR GeneID; 3474549; -. DR KEGG; sai:Saci_0458; -. DR PATRIC; fig|330779.12.peg.455; -. DR eggNOG; arCOG01704; Archaea. DR eggNOG; COG0452; LUCA. DR HOGENOM; HOG000037525; -. DR KO; K13038; -. DR OMA; LSAKCPV; -. DR OrthoDB; 56027at2157; -. DR BioCyc; SACI330779:G1G4L-446-MONOMER; -. DR UniPathway; UPA00241; UER00353. DR Proteomes; UP000001018; Chromosome. DR GO; GO:0010181; F:FMN binding; IEA:InterPro. DR GO; GO:0004632; F:phosphopantothenate--cysteine ligase activity; IEA:UniProtKB-EC. DR GO; GO:0004633; F:phosphopantothenoylcysteine decarboxylase activity; IEA:UniProtKB-EC. DR GO; GO:0015937; P:coenzyme A biosynthetic process; IEA:UniProtKB-UniPathway. DR GO; GO:0015941; P:pantothenate catabolic process; IEA:InterPro. DR Gene3D; 3.40.50.10300; -; 1. DR Gene3D; 3.40.50.1950; -; 1. DR InterPro; IPR035929; CoaB-like_sf. DR InterPro; IPR005252; CoaBC. DR InterPro; IPR007085; DNA/pantothenate-metab_flavo_C. DR InterPro; IPR036551; Flavin_trans-like. DR InterPro; IPR003382; Flavoprotein. DR Pfam; PF04127; DFP; 1. DR Pfam; PF02441; Flavoprotein; 1. DR SUPFAM; SSF102645; SSF102645; 1. DR SUPFAM; SSF52507; SSF52507; 1. DR TIGRFAMs; TIGR00521; coaBC_dfp; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001018}; KW Decarboxylase {ECO:0000256|RuleBase:RU364078}; KW Flavoprotein {ECO:0000256|RuleBase:RU364078}; KW FMN {ECO:0000256|RuleBase:RU364078}; KW Ligase {ECO:0000256|RuleBase:RU364078}; KW Lyase {ECO:0000256|RuleBase:RU364078, ECO:0000313|EMBL:AAY79868.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000001018}. FT DOMAIN 19 173 Flavoprotein. {ECO:0000259|Pfam:PF02441}. FT DOMAIN 191 377 DFP. {ECO:0000259|Pfam:PF04127}. SQ SEQUENCE 409 AA; 45552 MW; E22624F282D48029 CRC64; MVHPSKKIIG EVSRELLNKK ILVGVTASVS IYKSLDLVRA LMRRGANVRV IMSKDSIRLI NPMMFHWATG EEPVVSVGGE IEHVELAEEY DALVIAPSTA NTISKLANGI ADTSITLTAL NFVGIKKPVI LVPAMHLTMY EAPQFKENIE KLVKQGIEII SPEITRDVAH YPDIEYLSSY ITSFLLRGKD LKGYKIVVTA GPTREYIDPV RFISNSSSGT MGVSIANEAY FRGADVILVH GPLSSSVKPY TKRIRVDTTQ EMAENVEKLV RDEKYGIVIL AGAPADFKPK NTASSKIDSH SEVPKVELET TPKISSKLSI YRPLLVGFSA ETVNSDEELI EKAKMKKERH KFDIIVANNV KRKDIGFSSE YNEVIVIGNS FVRKLEKNYK TIIARELLDI VKYEVSRKV //