ID   Q4GZ95_TRYB2            Unreviewed;       589 AA.
AC   Q4GZ95;
DT   30-AUG-2005, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2005, sequence version 1.
DT   21-SEP-2011, entry version 36.
DE   SubName: Full=Cytidine triphosphate synthase, putative;
DE            EC=6.3.4.2;
GN   ORFNames=Tb927.1.1240;
OS   Trypanosoma brucei brucei (strain 927/4 GUTat10.1).
OC   Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=999953;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=927/4 GUTat10.1;
RX   MEDLINE=22789169; PubMed=12907729; DOI=10.1093/nar/gkg674;
RA   Hall N., Berriman M., Lennard N.J., Harris B.R., Hertz-Fowler C.,
RA   Bart-Delabesse E.N., Gerrard C.S., Atkin R.J., Barron A.J., Bowman S.,
RA   Bray-Allen S.P., Bringaud F., Clark L.N., Corton C.H., Cronin A.,
RA   Davies R., Doggett J., Fraser A., Grueter E., Hall S., Harper A.D.,
RA   Kay M.P., Leech V., Mayes R., Price C., Quail M.A., Rabbinowitsch E.,
RA   Reitter C., Rutherford K., Sasse J., Sharp S., Shownkeen R.,
RA   MacLeod A., Taylor S., Tweedie A., Turner C.M., Tait A., Gull K.,
RA   Barrell B., Melville S.E.;
RT   "The DNA sequence of chromosome I of an African trypanosome: gene
RT   content, chromosome organisation, recombination and polymorphism.";
RL   Nucleic Acids Res. 31:4864-4873(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=927/4 GUTat10.1;
RA   Hertz-Fowler C., Berriman M.;
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 320-589.
RA   Welin M., Moche M., Arrowsmith C.H., Berglund H., Bountra C.,
RA   Collins R., Dahlgren L.G., Edwards A.M., Flodin S., Flores A.,
RA   Graslund S., Hammarstrom M., Johansson A., Johansson I., Karlberg T.,
RA   Kotenyova T., Lehtio L., Nilsson M.E., Nyman T., Persson C.,
RA   Sagemark J., Schueler H., Siponen M.I., Thorsell A.G., Tresaugues L.,
RA   Van Den Berg S., Weigelt J., Wikstrom M., Wisniewska M., Nordlund P.,
RA   Structural Genomics Consortium;
RT   "Trypanosoma Brucei Ctps - Glutaminase Domain with Bound Acivicin.";
RL   Submitted (DEC-2008) to the PDB data bank.
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DR   EMBL; AL929603; CAJ16071.1; -; Genomic_DNA.
DR   RefSeq; XP_001218826.1; XM_001218825.1.
DR   PDB; 2W7T; X-ray; 2.10 A; A=320-589.
DR   PDBsum; 2W7T; -.
DR   ProteinModelPortal; Q4GZ95; -.
DR   STRING; Q4GZ95; -.
DR   GeneID; 4357199; -.
DR   KEGG; tbr:Tb927.1.1240; -.
DR   EuPathDB; EupathDB:Tb927.1.1240; -.
DR   eggNOG; KOG2387; -.
DR   HOGENOM; HBG597806; -.
DR   ProtClustDB; CLSZ2437074; -.
DR   GO; GO:0003883; F:CTP synthase activity; IEA:EC.
DR   GO; GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:InterPro.
DR   InterPro; IPR004468; CTP_synthase.
DR   InterPro; IPR017456; CTP_synthase_N.
DR   InterPro; IPR017926; GATASE_1.
DR   Pfam; PF06418; CTP_synth_N; 1.
DR   Pfam; PF00117; GATase; 1.
DR   TIGRFAMs; TIGR00337; PyrG; 1.
DR   PROSITE; PS51273; GATASE_TYPE_1; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Ligase.
SQ   SEQUENCE   589 AA;  65213 MW;  C3005DABAE3C386E CRC64;
     MEGSATAKAY MLPSPELRPV SGTGACKYIV VTGGVCSSLG KGVTTSATGA LLRAEGYQVC
     SIKIDPYINM DAGLMSPYEH GEVYVLDDGG EVDLDLGNYE RWMSVQLRRE HNITTGKVYQ
     KLINKERQGG FLGKTVQLVP HFTNDVVESI FRVSQSPVDE SGAQPEICMI ELGGTVGDME
     SQPFVEALRR LRCLVGPDEF CLMHTTYLPV FGGSQKTKPT QHSTRTLLSM GLQPDILICR
     SENRLTPDAK EKLSNLCGVR SGDIVSAPNV SCLYEVPVVF TKDGLVDRLV EKLRLVKRTP
     ATDVPRIDTY KTYVKILRNM SNPTVRIAFV GKYLQDAGDT YFSVLQCFEH CQIALQVRLD
     ILYVDSEELE GPNADEARKA LLGCDGIFVP GGFGNRGVDG KCAAAQVARM NNIPYFGVCL
     GMQVAVIELS RNVVGWSDAN SEEFNKESTH QVVRIMDCDR NKMGANMHLG ACDVHIVEKS
     SIMAKIYSKS NIVVERHRHR YEVNTAYFED LRKAGLCISA VTDPTFSSRC RVEAVENPSL
     RFFLAVQFHP EFISTPMDPA PTYLSFMAAA AKKDYVWPQK CSQRRLKQA
//