ID Q4GVU8_HUMAN Unreviewed; 513 AA. AC Q4GVU8; DT 30-AUG-2005, integrated into UniProtKB/TrEMBL. DT 30-AUG-2005, sequence version 1. DT 08-FEB-2011, entry version 44. DE SubName: Full=Cytochrome c oxidase subunit I; DE SubName: Full=Cytochrome oxydase subunit I; GN Name=COI; Synonyms=COX1; OS Homo sapiens (Human). OG Mitochondrion. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=TCsq0007, HNsq0219, and PDsq0056; RX PubMed=15466285; DOI=10.1101/gr.2286304; RA Tanaka M., Cabrera V.M., Gonzalez A.M., Larruga J.M., Takeyasu T., RA Fuku N., Guo L., Hirose R., Fujita Y., Kurata M., Shinoda K., RA Umetsu K., Yamada Y., Oshida Y., Sato Y., Hattori N., Mizuno Y., RA Arai Y., Hirose N., Ohta S., Ogawa O., Tanaka Y., Kawamori R., RA Shamoto-Nagai M., Maruyama W., Shimokata H., Suzuki R., Shimodaira H.; RT "Mitochondrial genome variation in eastern Asia and the peopling of RT Japan."; RL Genome Res. 14:1832-1850(2004). RN [2] RP NUCLEOTIDE SEQUENCE. RC STRAIN=TCsq0007, HNsq0219, and PDsq0056; RA Tanaka M.; RT "Human mitochondrial genome polymorphism database (mtSNP)."; RL Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Chuk101; RX PubMed=18452887; DOI=10.1016/j.ajhg.2008.03.019; RA Volodko N.V., Starikovskaya E.B., Mazunin I.O., Eltsov N.P., RA Naidenko P.V., Wallace D.C., Sukernik R.I.; RT "Mitochondrial genome diversity in arctic Siberians, with particular RT reference to the evolutionary history of Beringia and Pleistocenic RT peopling of the Americas."; RL Am. J. Hum. Genet. 82:1084-1100(2008). RN [4] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mdmd25; RA Kazuno A., Munakata K., Mori K., Nanko S., Kunugi H., Nakamura K., RA Mori N., Yamada K., Yoshikawa T., Kato N., Kato T.; RT "Mitochondrial DNA haplogroup analysis in patients with Bipolar RT Disorder."; RL Am. J. Med. Genet. B Neuropsychiatr. Genet. 0:0-0(2008). RN [5] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mdmd25; RX PubMed=16895436; DOI=10.1371/journal.pgen.0020128; RA Kazuno A., Munakata K., Nagai T., Shimozono S., Tanaka M., Yoneda M., RA Kato N., Miyawaki A., Kato T.; RT "Identification of mitochondrial DNA polymorphisms that alter RT mitochondrial matrix pH and intracellular calcium dynamics."; RL PLoS Genet. 2:e128-e128(2006). RN [6] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mdmd25; RX PubMed=16048457; DOI=10.1111/j.1440-1819.2005.01404.x; RA Kazuno A., Munakata K., Mori K., Tanaka M., Nanko S., Kunugi H., RA Umekage T., Tochigi M., Kohda K., Sasaki T., Akiyama T., Washizuka S., RA Kato N., Kato T.; RT "Mitochondrial DNA sequence analysis of patients with 'atypical RT psychosis'."; RL Psychiatry Clin. Neurosci. 59:497-503(2005). RN [7] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mdmd25; RX PubMed=17288645; RA Kazuno A., Munakata K., Kato N., Kato T.; RT "Mitochondrial DNA-dependent effects of valproate on mitochondrial RT calcium levels in transmitochondrial cybrids."; RL Int. J. Neuropsychopharmacol. 11:71-78(2008). RN [8] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mdmd25; RX PubMed=18226984; DOI=10.1016/j.mito.2007.12.002; RA Kazuno A., Munakata K., Tanaka M., Kato N., Kato T.; RT "Relationships between mitochondrial DNA subhaplogroups and RT intracellular calcium dynamics."; RL Mitochondrion 8:164-169(2008). RN [9] RP NUCLEOTIDE SEQUENCE. RC STRAIN=GL37; RX PubMed=19624810; DOI=10.1186/1471-2148-9-173; RA Kumar S., Ravuri R.R., Koneru P., Urade B.P., Sarkar B.N., RA Chandrasekar A., Rao V.R.; RT "Reconstructing Indian-Australian phylogenetic link."; RL BMC Evol. Biol. 9:173-173(2009). RN [10] RP NUCLEOTIDE SEQUENCE. RC STRAIN=GL37; RX PubMed=19823670; DOI=10.1371/journal.pone.0007447; RA Chandrasekar A., Kumar S., Sreenath J., Sarkar B.N., Urade B.P., RA Mallick S., Bandopadhyay S.S., Barua P., Barik S.S., Basu D., RA Kiran U., Gangopadhyay P., Sahani R., Prasad B.V., Gangopadhyay S., RA Lakshmi G.R., Ravuri R.R., Padmaja K., Venugopal P.N., Sharma M.B., RA Rao V.R.; RT "Updating phylogeny of mitochondrial DNA macrohaplogroup m in India: RT dispersal of modern human in South Asian corridor."; RL PLoS ONE 4:E7447-E7447(2009). RN [11] RP NUCLEOTIDE SEQUENCE. RC STRAIN=S-643125; RX PubMed=20587512; DOI=10.1101/gr.109231.110; RA Perego U.A., Angerhofer N., Pala M., Olivieri A., Lancioni H., RA Kashani B.H., Carossa V., Ekins J.E., Gomez-Carballa A., Huber G., RA Zimmermann B., Corach D., Babudri N., Panara F., Myres N.M., RA Parson W., Semino O., Salas A., Woodward S.R., Achilli A., Torroni A.; RT "The initial peopling of the Americas: A growing number of founding RT mitochondrial genomes from Beringia."; RL Genome Res. 0:0-0(2010). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; EU482342; ACA22373.1; -; Genomic_DNA. DR EMBL; FJ383204; ACM69780.1; -; Genomic_DNA. DR EMBL; HM107337; ADG46466.1; -; Genomic_DNA. DR EMBL; AP008266; BAE07443.1; -; Genomic_DNA. DR EMBL; AP008387; BAE09016.1; -; Genomic_DNA. DR EMBL; AP008695; BAE13022.1; -; Genomic_DNA. DR EMBL; AP009443; BAG39021.1; -; Genomic_DNA. DR IPI; IPI00464968; -. DR ProteinModelPortal; Q4GVU8; -. DR SMR; Q4GVU8; 1-511. DR STRING; Q4GVU8; -. DR Ensembl; ENST00000361624; ENSP00000354499; ENSG00000198804. DR HGNC; HGNC:7419; MT-CO1. DR HOVERGEN; HBG003841; -. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW. DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:EC. DR GO; GO:0009055; F:electron carrier activity; IEA:InterPro. DR GO; GO:0020037; F:heme binding; IEA:InterPro. DR GO; GO:0009060; P:aerobic respiration; IEA:InterPro. DR GO; GO:0022900; P:electron transport chain; IEA:UniProtKB-KW. DR InterPro; IPR000883; Cyt_c_oxidase_su1. DR Gene3D; G3DSA:1.20.210.10; COX1; 1. DR PANTHER; PTHR10422; COX1; 1. DR Pfam; PF00115; COX1; 1. DR PRINTS; PR01165; CYCOXIDASEI. DR SUPFAM; SSF81442; COX1; 1. DR PROSITE; PS50855; COX1; 1. DR PROSITE; PS00077; COX1_CUB; 1. PE 4: Predicted; KW Mitochondrion. SQ SEQUENCE 513 AA; 57071 MW; 766088D9F783F77C CRC64; MFADRWLFST NHKDIGTLYL LFGAWAGVLG TALSLLIRTE LGQPGNLLGN DHIYNVIVTA HAFVMIFFMV MPIMIGGFGN WLVPLMIGAP DMAFPRMNNM SFWLLPPSLL LLLASAMVEA GAGTGWTVYP PLAGNYSHPG ASVDLTIFSL HLAGVSSILG AINFITTIIN MKPPAMTQYQ TPLFVWSVLI TAVLLLLSLP VLAAGITMLL TDRNLNTTFF DPAGGGDPIL YQHLFWFFGH PEVYILILPG FGMISHIVTY YSGKKEPFGY MGMVWAMMSI GFLGFIVWAH HMFTVGMDVD TRAYFTSATM IIAIPTGVKV FSWLATLHGS NMKWSAAVLW ALGFIFLFTV GGLTGIVLAN SSLDIVLHDT YYVVAHFHYV LSMGAVFAIM GGFIHWFPLF SGYTLDQTYA KIHFTIMFIG VNLTFFPQHF LGLSGMPRRY SDYPDAYTTW NILSSVGSFI SLTAVMLMIF MIWEAFASKR KVLMVEEPSM NLEWLYGCPP PYHTFEEPVY MKS //