ID   Q4GVU8_HUMAN            Unreviewed;       513 AA.
AC   Q4GVU8;
DT   30-AUG-2005, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2005, sequence version 1.
DT   13-JUL-2010, entry version 39.
DE   RecName: Full=Cytochrome c oxidase subunit 1;
DE            EC=1.9.3.1;
GN   Name=COI; Synonyms=COX1;
OS   Homo sapiens (Human).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=TCsq0007, HNsq0219, and PDsq0056;
RX   PubMed=15466285; DOI=10.1101/gr.2286304;
RA   Tanaka M., Cabrera V.M., Gonzalez A.M., Larruga J.M., Takeyasu T.,
RA   Fuku N., Guo L., Hirose R., Fujita Y., Kurata M., Shinoda K.,
RA   Umetsu K., Yamada Y., Oshida Y., Sato Y., Hattori N., Mizuno Y.,
RA   Arai Y., Hirose N., Ohta S., Ogawa O., Tanaka Y., Kawamori R.,
RA   Shamoto-Nagai M., Maruyama W., Shimokata H., Suzuki R., Shimodaira H.;
RT   "Mitochondrial genome variation in eastern Asia and the peopling of
RT   Japan.";
RL   Genome Res. 14:1832-1850(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=TCsq0007, HNsq0219, and PDsq0056;
RA   Tanaka M.;
RT   "Human mitochondrial genome polymorphism database (mtSNP).";
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Chuk101;
RX   PubMed=18452887; DOI=10.1016/j.ajhg.2008.03.019;
RA   Volodko N.V., Starikovskaya E.B., Mazunin I.O., Eltsov N.P.,
RA   Naidenko P.V., Wallace D.C., Sukernik R.I.;
RT   "Mitochondrial genome diversity in arctic Siberians, with particular
RT   reference to the evolutionary history of Beringia and Pleistocenic
RT   peopling of the Americas.";
RL   Am. J. Hum. Genet. 82:1084-1100(2008).
RN   [4]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Mdmd25;
RA   Kazuno A., Munakata K., Mori K., Nanko S., Kunugi H., Nakamura K.,
RA   Mori N., Yamada K., Yoshikawa T., Kato N., Kato T.;
RT   "Mitochondrial DNA haplogroup analysis in patients with Bipolar
RT   Disorder.";
RL   Am. J. Med. Genet. B Neuropsychiatr. Genet. 0:0-0(2008).
RN   [5]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Mdmd25;
RX   PubMed=16895436; DOI=10.1371/journal.pgen.0020128;
RA   Kazuno A., Munakata K., Nagai T., Shimozono S., Tanaka M., Yoneda M.,
RA   Kato N., Miyawaki A., Kato T.;
RT   "Identification of mitochondrial DNA polymorphisms that alter
RT   mitochondrial matrix pH and intracellular calcium dynamics.";
RL   PLoS Genet. 2:e128-e128(2006).
RN   [6]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Mdmd25;
RX   PubMed=16048457; DOI=10.1111/j.1440-1819.2005.01404.x;
RA   Kazuno A., Munakata K., Mori K., Tanaka M., Nanko S., Kunugi H.,
RA   Umekage T., Tochigi M., Kohda K., Sasaki T., Akiyama T., Washizuka S.,
RA   Kato N., Kato T.;
RT   "Mitochondrial DNA sequence analysis of patients with 'atypical
RT   psychosis'.";
RL   Psychiatry Clin. Neurosci. 59:497-503(2005).
RN   [7]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Mdmd25;
RX   PubMed=17288645;
RA   Kazuno A., Munakata K., Kato N., Kato T.;
RT   "Mitochondrial DNA-dependent effects of valproate on mitochondrial
RT   calcium levels in transmitochondrial cybrids.";
RL   Int. J. Neuropsychopharmacol. 11:71-78(2008).
RN   [8]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Mdmd25;
RX   PubMed=18226984; DOI=10.1016/j.mito.2007.12.002;
RA   Kazuno A., Munakata K., Tanaka M., Kato N., Kato T.;
RT   "Relationships between mitochondrial DNA subhaplogroups and
RT   intracellular calcium dynamics.";
RL   Mitochondrion 8:164-169(2008).
RN   [9]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=GL37;
RX   PubMed=19624810; DOI=10.1186/1471-2148-9-173;
RA   Kumar S., Ravuri R.R., Koneru P., Urade B.P., Sarkar B.N.,
RA   Chandrasekar A., Rao V.R.;
RT   "Reconstructing Indian-Australian phylogenetic link.";
RL   BMC Evol. Biol. 9:173-173(2009).
RN   [10]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=GL37;
RX   PubMed=19823670; DOI=10.1371/journal.pone.0007447;
RA   Chandrasekar A., Kumar S., Sreenath J., Sarkar B.N., Urade B.P.,
RA   Mallick S., Bandopadhyay S.S., Barua P., Barik S.S., Basu D.,
RA   Kiran U., Gangopadhyay P., Sahani R., Prasad B.V., Gangopadhyay S.,
RA   Lakshmi G.R., Ravuri R.R., Padmaja K., Venugopal P.N., Sharma M.B.,
RA   Rao V.R.;
RT   "Updating phylogeny of mitochondrial DNA macrohaplogroup m in India:
RT   dispersal of modern human in South Asian corridor.";
RL   PLoS ONE 4:E7447-E7447(2009).
RN   [11]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=S-643125;
RA   Perego U.A., Angerhofer N., Pala M., Olivieri A., Lancioni H.,
RA   Kashani B.Hooshiar., Carossa V., Ekins J.E., Gomez-Carballa A.,
RA   Huber G., Zimmermann B., Corach D., Babudri N., Panara F., Myres N.M.,
RA   Parson W., Semino O., Salas A., Woodward S.R., Achilli A., Torroni A.;
RT   "The initial peopling of the Americas: a growing number of founding
RT   mitochondrial genomes from Beringia.";
RL   Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory
CC       chain that catalyzes the reduction of oxygen to water. Subunits 1-
CC       3 form the functional core of the enzyme complex. CO I is the
CC       catalytic subunit of the enzyme. Electrons originating in
CC       cytochrome c are transferred via the copper A center of subunit 2
CC       and heme A of subunit 1 to the bimetallic center formed by heme A3
CC       and copper B (By similarity).
CC   -!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) + 4 H(+) = 4
CC       ferricytochrome c + 2 H(2)O.
CC   -!- PATHWAY: Energy metabolism; oxidative phosphorylation.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass
CC       membrane protein (By similarity).
CC   -!- SIMILARITY: Belongs to the heme-copper respiratory oxidase family.
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DR   EMBL; EU482342; ACA22373.1; -; Genomic_DNA.
DR   EMBL; FJ383204; ACM69780.1; -; Genomic_DNA.
DR   EMBL; HM107337; ADG46466.1; -; Genomic_DNA.
DR   EMBL; AP008266; BAE07443.1; -; Genomic_DNA.
DR   EMBL; AP008387; BAE09016.1; -; Genomic_DNA.
DR   EMBL; AP008695; BAE13022.1; -; Genomic_DNA.
DR   EMBL; AP009443; BAG39021.1; -; Genomic_DNA.
DR   IPI; IPI00464968; -.
DR   SMR; Q4GVU8; 1-511.
DR   STRING; Q4GVU8; -.
DR   Ensembl; ENST00000361624; ENSP00000354499; ENSG00000198804; Homo sapiens.
DR   HOVERGEN; HBG003841; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:EC.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0009060; P:aerobic respiration; IEA:InterPro.
DR   GO; GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
DR   GO; GO:0006810; P:transport; IEA:UniProtKB-KW.
DR   InterPro; IPR000883; Cyt_c_oxidase_su1.
DR   Gene3D; G3DSA:1.20.210.10; COX1; 1.
DR   PANTHER; PTHR10422; COX1; 1.
DR   Pfam; PF00115; COX1; 1.
DR   PRINTS; PR01165; CYCOXIDASEI.
DR   SUPFAM; SSF81442; COX1; 1.
DR   PROSITE; PS50855; COX1; 1.
DR   PROSITE; PS00077; COX1_CUB; 1.
PE   3: Inferred from homology;
KW   Copper; Electron transport; Heme; Iron; Membrane; Metal-binding;
KW   Mitochondrion; Mitochondrion inner membrane; Oxidoreductase;
KW   Respiratory chain; Transmembrane; Transport.
SQ   SEQUENCE   513 AA;  57071 MW;  766088D9F783F77C CRC64;
     MFADRWLFST NHKDIGTLYL LFGAWAGVLG TALSLLIRTE LGQPGNLLGN DHIYNVIVTA
     HAFVMIFFMV MPIMIGGFGN WLVPLMIGAP DMAFPRMNNM SFWLLPPSLL LLLASAMVEA
     GAGTGWTVYP PLAGNYSHPG ASVDLTIFSL HLAGVSSILG AINFITTIIN MKPPAMTQYQ
     TPLFVWSVLI TAVLLLLSLP VLAAGITMLL TDRNLNTTFF DPAGGGDPIL YQHLFWFFGH
     PEVYILILPG FGMISHIVTY YSGKKEPFGY MGMVWAMMSI GFLGFIVWAH HMFTVGMDVD
     TRAYFTSATM IIAIPTGVKV FSWLATLHGS NMKWSAAVLW ALGFIFLFTV GGLTGIVLAN
     SSLDIVLHDT YYVVAHFHYV LSMGAVFAIM GGFIHWFPLF SGYTLDQTYA KIHFTIMFIG
     VNLTFFPQHF LGLSGMPRRY SDYPDAYTTW NILSSVGSFI SLTAVMLMIF MIWEAFASKR
     KVLMVEEPSM NLEWLYGCPP PYHTFEEPVY MKS
//