ID   Q4GEA1_HUMAN            Unreviewed;       347 AA.
AC   Q4GEA1;
DT   30-AUG-2005, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2005, sequence version 1.
DT   16-MAR-2016, entry version 65.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 2 {ECO:0000256|RuleBase:RU003403, ECO:0000256|SAAS:SAAS00093744};
DE            EC=1.6.5.3 {ECO:0000256|RuleBase:RU003403, ECO:0000256|SAAS:SAAS00093728};
GN   Name=NADH2 {ECO:0000313|EMBL:BAE13242.1};
GN   Synonyms=ND2 {ECO:0000313|EMBL:AEG63015.1}, ndh2
GN   {ECO:0000313|EMBL:BAN79759.1};
OS   Homo sapiens (Human).
OG   Mitochondrion {ECO:0000313|EMBL:BAE13242.1}.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAE13242.1};
RN   [1] {ECO:0000313|EMBL:BAE13242.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HNsq0238 {ECO:0000313|EMBL:BAE13242.1};
RX   PubMed=15466285; DOI=10.1101/gr.2286304;
RA   Tanaka M., Cabrera V.M., Gonzalez A.M., Larruga J.M., Takeyasu T.,
RA   Fuku N., Guo L., Hirose R., Fujita Y., Kurata M., Shinoda K.,
RA   Umetsu K., Yamada Y., Oshida Y., Sato Y., Hattori N., Mizuno Y.,
RA   Arai Y., Hirose N., Ohta S., Ogawa O., Tanaka Y., Kawamori R.,
RA   Shamoto-Nagai M., Maruyama W., Shimokata H., Suzuki R., Shimodaira H.;
RT   "Mitochondrial genome variation in eastern Asia and the peopling of
RT   Japan.";
RL   Genome Res. 14:1832-1850(2004).
RN   [2] {ECO:0000313|EMBL:BAG39189.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Mdmd38 {ECO:0000313|EMBL:BAG39189.1}, and Mdmd39
RC   {ECO:0000313|EMBL:BAG39202.1};
RX   PubMed=16048457; DOI=10.1111/j.1440-1819.2005.01404.x;
RA   Kazuno A., Munakata K., Mori K., Tanaka M., Nanko S., Kunugi H.,
RA   Umekage T., Tochigi M., Kohda K., Sasaki T., Akiyama T., Washizuka S.,
RA   Kato N., Kato T.;
RT   "Mitochondrial DNA sequence analysis of patients with 'atypical
RT   psychosis'.";
RL   Psychiatry Clin. Neurosci. 59:497-503(2005).
RN   [3] {ECO:0000313|EMBL:BAE13242.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HNsq0238 {ECO:0000313|EMBL:BAE13242.1};
RA   Tanaka M.;
RT   "Human mitochondrial genome polymorphism database (mtSNP).";
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:BAG39189.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Mdmd38 {ECO:0000313|EMBL:BAG39189.1}, and Mdmd39
RC   {ECO:0000313|EMBL:BAG39202.1};
RX   PubMed=16895436; DOI=10.1371/journal.pgen.0020128;
RA   Kazuno A., Munakata K., Nagai T., Shimozono S., Tanaka M., Yoneda M.,
RA   Kato N., Miyawaki A., Kato T.;
RT   "Identification of mitochondrial DNA polymorphisms that alter
RT   mitochondrial matrix pH and intracellular calcium dynamics.";
RL   PLoS Genet. 2:e128-e128(2006).
RN   [5] {ECO:0000313|EMBL:BAG39189.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Mdmd38 {ECO:0000313|EMBL:BAG39189.1}, and Mdmd39
RC   {ECO:0000313|EMBL:BAG39202.1};
RA   Kazuno A., Munakata K., Mori K., Nanko S., Kunugi H., Nakamura K.,
RA   Mori N., Yamada K., Yoshikawa T., Kato N., Kato T.;
RT   "Mitochondrial DNA haplogroup analysis in patients with Bipolar
RT   Disorder.";
RL   Am. J. Med. Genet. B Neuropsychiatr. Genet. 0:0-0(2008).
RN   [6] {ECO:0000313|EMBL:BAG39189.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Mdmd38 {ECO:0000313|EMBL:BAG39189.1}, and Mdmd39
RC   {ECO:0000313|EMBL:BAG39202.1};
RX   PubMed=17288645;
RA   Kazuno A., Munakata K., Kato N., Kato T.;
RT   "Mitochondrial DNA-dependent effects of valproate on mitochondrial
RT   calcium levels in transmitochondrial cybrids.";
RL   Int. J. Neuropsychopharmacol. 11:71-78(2008).
RN   [7] {ECO:0000313|EMBL:BAG39189.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Mdmd38 {ECO:0000313|EMBL:BAG39189.1}, and Mdmd39
RC   {ECO:0000313|EMBL:BAG39202.1};
RX   PubMed=18226984; DOI=10.1016/j.mito.2007.12.002;
RA   Kazuno A., Munakata K., Tanaka M., Kato N., Kato T.;
RT   "Relationships between mitochondrial DNA subhaplogroups and
RT   intracellular calcium dynamics.";
RL   Mitochondrion 8:164-169(2008).
RN   [8] {ECO:0000313|EMBL:BAH11055.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=19066930; DOI=10.1007/s00414-008-0308-5;
RA   Nohira C., Maruyama S., Minaguchi K.;
RT   "Phylogenetic classification of Japanese mtDNA assisted by complete
RT   mitochondrial DNA sequences.";
RL   Int. J. Legal Med. 124:7-12(2010).
RN   [9] {ECO:0000313|EMBL:AEG63015.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Esophageal cancerous tissue {ECO:0000313|EMBL:AEG63015.1}, and
RC   Paracancerous normal esophageal tissue {ECO:0000313|EMBL:AEG64224.1};
RX   PubMed=22130971; DOI=10.1093/molbev/msr290;
RA   Liu J., Wang L.D., Sun Y.B., Li E.M., Xu L.Y., Zhang Y.P., Yao Y.G.,
RA   Kong Q.P.;
RT   "Deciphering the signature of selective constraints on cancerous
RT   mitochondrial genome.";
RL   Mol. Biol. Evol. 29:1255-1261(2012).
RN   [10] {ECO:0000313|EMBL:BAN79759.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Mikami E., Fuku N., Kong Q.P., Takahashi H., Ohiwa N., Murakami H.,
RA   Miyachi M., Pitsiladis Y.P., Higuchi M., Kawahara T., Tanaka M.;
RT   "Comprehensive analysis of common and rare mitochondrial DNA variants
RT   in elite Japanese athletes: Case-control study.";
RL   Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
RN   [11] {ECO:0000313|EMBL:AFO26853.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=24341918; DOI=10.1111/acel.12186;
RA   Raule N., Sevini F., Li S., Barbieri A., Tallaro F., Lomartire L.,
RA   Vianello D., Montesanto A., Moilanen J.S., Bezrukov V., Blanche H.,
RA   Hervonen A., Christensen K., Deiana L., Gonos E.S., Kirkwood T.B.,
RA   Kristensen P., Leon A., Pelicci P.G., Poulain M., Rea I.M.,
RA   Remacle J., Robine J.M., Schreiber S., Sikora E., Eline Slagboom P.,
RA   Spazzafumo L., Antonietta Stazi M., Toussaint O., Vaupel J.W.,
RA   Rose G., Majamaa K., Perola M., Johnson T.E., Bolund L., Yang H.,
RA   Passarino G., Franceschi C.;
RT   "The co-occurrence of mtDNA mutations on different oxidative
RT   phosphorylation subunits, not detected by haplogroup analysis, affects
RT   human longevity and is population specific.";
RL   Aging Cell 13:401-407(2014).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory
CC       chain NADH dehydrogenase (Complex I) that is believed to belong to
CC       the minimal assembly required for catalysis. Complex I functions
CC       in the transfer of electrons from NADH to the respiratory chain.
CC       The immediate electron acceptor for the enzyme is believed to be
CC       ubiquinone (By similarity). {ECO:0000256|SAAS:SAAS00207298}.
CC   -!- CATALYTIC ACTIVITY: NADH + ubiquinone + 5 H(+)(In) = NAD(+) +
CC       ubiquinol + 4 H(+)(Out). {ECO:0000256|RuleBase:RU003403,
CC       ECO:0000256|SAAS:SAAS00093735}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000256|RuleBase:RU003403, ECO:0000256|SAAS:SAAS00093751};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003403,
CC       ECO:0000256|SAAS:SAAS00093751}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 2 family.
CC       {ECO:0000256|RuleBase:RU003403}.
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DR   EMBL; JF824882; AEG63015.1; -; Genomic_DNA.
DR   EMBL; JF824975; AEG64224.1; -; Genomic_DNA.
DR   EMBL; JX153283; AFO26853.1; -; Genomic_DNA.
DR   EMBL; AP008712; BAE13242.1; -; Genomic_DNA.
DR   EMBL; AP009456; BAG39189.1; -; Genomic_DNA.
DR   EMBL; AP009457; BAG39202.1; -; Genomic_DNA.
DR   EMBL; AP010836; BAH11055.1; -; Genomic_DNA.
DR   EMBL; AP013142; BAN79759.1; -; Genomic_DNA.
DR   STRING; 9606.ENSP00000355046; -.
DR   eggNOG; KOG4668; Eukaryota.
DR   eggNOG; COG1009; LUCA.
DR   HOVERGEN; HBG016692; -.
DR   NextBio; 35538764; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:InterPro.
DR   InterPro; IPR010933; NADH_DH_su2_C.
DR   InterPro; IPR003917; NADH_UbQ_OxRdtase_chain2.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   Pfam; PF06444; NADH_dehy_S2_C; 1.
DR   Pfam; PF00361; Proton_antipo_M; 1.
DR   PRINTS; PR01436; NADHDHGNASE2.
PE   3: Inferred from homology;
KW   Electron transport {ECO:0000256|SAAS:SAAS00464461};
KW   Membrane {ECO:0000256|SAAS:SAAS00464716, ECO:0000256|SAM:Phobius};
KW   Mitochondrion {ECO:0000256|RuleBase:RU000318,
KW   ECO:0000256|SAAS:SAAS00464403, ECO:0000313|EMBL:BAE13242.1};
KW   Mitochondrion inner membrane {ECO:0000256|SAAS:SAAS00464436};
KW   NAD {ECO:0000256|RuleBase:RU000317, ECO:0000256|SAAS:SAAS00464384};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000317,
KW   ECO:0000256|SAAS:SAAS00464503};
KW   Respiratory chain {ECO:0000256|SAAS:SAAS00464594};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00464491,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00464584,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00464711};
KW   Ubiquinone {ECO:0000256|RuleBase:RU000318,
KW   ECO:0000256|SAAS:SAAS00464648}.
FT   TRANSMEM     56     76       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     96    115       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    151    171       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    178    196       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    202    219       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    239    257       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    277    305       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    325    346       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       23    284       Proton_antipo_M. {ECO:0000259|Pfam:
FT                                PF00361}.
FT   DOMAIN      290    343       NADH_dehy_S2_C. {ECO:0000259|Pfam:
FT                                PF06444}.
SQ   SEQUENCE   347 AA;  38927 MW;  208FD982317C358D CRC64;
     MNPLAQPVIY STIFAGTLIT ALSSHWFFTW VGLEMNMLAF IPVLTKKMNP RSTEAAIKYF
     LTQATASMIL LMAILFNNML SGQWTMTNTT NQYSSLMIMM AMAMKLGMAP FHFWVPEVTQ
     GTPLTSGLLL LTWQKLAPIS IMYQISPSLN VSLLLTLSIL SIMAGSWGGL NQTQLRKILA
     YSSITHMGWM MAVLPYNPNM TILNLTIYII LTTTAFLLLN LNSSTTTLLL SRTWNKLTWL
     TPLIPSTLLS LGGLPPLTGF LPKWAIIEEF TKNNSLIIPT IMATITLLNL YFYLRLIYST
     SITLLPMSNN VKMKWQLEHT KPTPFLPTLI ALTTLLLPIS PFMLMIL
//