ID Q4G7F8_HUMAN Unreviewed; 513 AA. AC Q4G7F8; DT 30-AUG-2005, integrated into UniProtKB/TrEMBL. DT 30-AUG-2005, sequence version 1. DT 03-SEP-2014, entry version 86. DE RecName: Full=Cytochrome c oxidase subunit 1; DE EC=1.9.3.1; GN Name=COI; Synonyms=COX1; OS Homo sapiens (Human). OG Mitochondrion. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=MTDNA174, MTDNA242, MTDNA347, and MTDNA430; RX PubMed=11938495; DOI=10.1086/339933; RA Herrnstadt C., Elson J.L., Fahy E., Preston G., Turnbull D.M., RA Anderson C., Ghosh S.S., Olefsky J.M., Beal M.F., Davis R.E., RA Howell N.; RT "Reduced-median-network analysis of complete mitochondrial DNA coding- RT region sequences for the major African, Asian, and European RT haplogroups."; RL Am. J. Hum. Genet. 70:1152-1171(2002). RN [2] RP NUCLEOTIDE SEQUENCE. RC STRAIN=JDsq0080, NDsq0116, and TCsq0019; RX PubMed=15466285; DOI=10.1101/gr.2286304; RA Tanaka M., Cabrera V.M., Gonzalez A.M., Larruga J.M., Takeyasu T., RA Fuku N., Guo L., Hirose R., Fujita Y., Kurata M., Shinoda K., RA Umetsu K., Yamada Y., Oshida Y., Sato Y., Hattori N., Mizuno Y., RA Arai Y., Hirose N., Ohta S., Ogawa O., Tanaka Y., Kawamori R., RA Shamoto-Nagai M., Maruyama W., Shimokata H., Suzuki R., Shimodaira H.; RT "Mitochondrial genome variation in eastern Asia and the peopling of RT Japan."; RL Genome Res. 14:1832-1850(2004). RN [3] RP NUCLEOTIDE SEQUENCE. RC STRAIN=NDsq0116; RA Guo L., Oshida Y., Fuku N., Takeyasu T., Fujita Y., Kurata M., RA Sato Y., Ito M., Tanaka M.; RT "Mitochondrial genome polymorphisms associated with type-2 diabetes or RT obesity."; RL Mitochondrion 0:0-0(2004). RN [4] RP NUCLEOTIDE SEQUENCE. RC STRAIN=JDsq0080, NDsq0116, and TCsq0019; RA Tanaka M.; RT "Human mitochondrial genome polymorphism database (mtSNP)."; RL Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE. RC STRAIN=AS10, and EU79; RX PubMed=16172508; DOI=10.1534/genetics.105.043901; RA Kivisild T., Shen P., Wall D.P., Do B., Sung R., Davis K.K., RA Passarino G., Underhill P.A., Scharfe C., Torroni A., Scozzari R., RA Modiano D., Coppa A., de Knjiff P., Feldman M.W., Cavalli-Sforza L.L., RA Oefner P.J.; RT "The role of selection in the evolution of human mitochondrial RT genomes."; RL Genetics 172:373-387(2006). RN [6] RP NUCLEOTIDE SEQUENCE. RC STRAIN=0185P, 0259P, and 2038T; RX PubMed=16901986; DOI=10.1093/molbev/msl084; RA Fraumene C., Belle E.M., Castri L., Sanna S., Mancosu G., Cosso M., RA Marras F., Barbujani G., Pirastu M., Angius A.; RT "High resolution analysis and phylogenetic network construction using RT complete mtDNA sequences in sardinian genetic isolates."; RL Mol. Biol. Evol. 23:2101-2111(2006). RN [7] RP NUCLEOTIDE SEQUENCE. RC STRAIN=PA_EU_IT_0029; TISSUE=Breast cancer; RX PubMed=17517629; DOI=10.1073/pnas.0703056104; RA Gasparre G., Porcelli A.M., Bonora E., Pennisi L.F., Toller M., RA Iommarini L., Ghelli A., Moretti M., Betts C.M., Martinelli G.N., RA Ceroni A.R., Curcio F., Carelli V., Rugolo M., Tallini G., Romeo G.; RT "Disruptive mitochondrial DNA mutations in complex I subunits are RT markers of oncocytic phenotype in thyroid tumors."; RL Proc. Natl. Acad. Sci. U.S.A. 104:9001-9006(2007). RN [8] RP NUCLEOTIDE SEQUENCE. RC STRAIN=MTDNA174, MTDNA242, MTDNA347, MTDNA430, and PA_EU_IT_0029; RC TISSUE=Breast cancer; RG HmtDB; RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases. RN [9] RP NUCLEOTIDE SEQUENCE. RC STRAIN=MTDNA174, MTDNA242, MTDNA347, and MTDNA430; RA Herrnstadt C., Fahy E., Preston G., Anderson C., Ghosh S.S., RA Davis R.E., Howell N.; RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases. RN [10] RP NUCLEOTIDE SEQUENCE. RC STRAIN=L3e-2-04, and L3e-2-08; RX PubMed=19083815; RA Just R.S., Diegoli T.M., Saunier J.L., Irwin J.A., Parsons T.J.; RT "Complete mitochondrial genome sequences for 265 African American and RT U.S. "Hispanic" individuals."; RL Forensic Sci. Int. Genet. 2:e45-e48(2008). RN [11] RP NUCLEOTIDE SEQUENCE. RC STRAIN=R871_R1a, VN29, and VT33; RX PubMed=18477584; DOI=10.1093/molbev/msn114; RA Malyarchuk B., Grzybowski T., Derenko M., Perkova M., Vanecek T., RA Lazur J., Gomolcak P., Tsybovsky I.; RT "Mitochondrial DNA phylogeny in Eastern and Western Slavs."; RL Mol. Biol. Evol. 25:1651-1658(2008). RN [12] RP NUCLEOTIDE SEQUENCE. RC STRAIN=1429, and 1600; RX PubMed=18446216; DOI=10.1371/journal.pone.0002062; RA Behar D.M., Metspalu E., Kivisild T., Rosset S., Tzur S., Hadid Y., RA Yudkovsky G., Rosengarten D., Pereira L., Amorim A., Kutuev I., RA Gurwitz D., Bonne-Tamir B., Villems R., Skorecki K.; RT "Counting the founders: the matrilineal genetic ancestry of the Jewish RT Diaspora."; RL PLoS ONE 3:e2062-e2062(2008). RN [13] RP NUCLEOTIDE SEQUENCE. RA Greenspan B.; RL Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases. RN [14] RP NUCLEOTIDE SEQUENCE. RC STRAIN=TC7; RX PubMed=19133286; DOI=10.1016/j.mad.2008.12.001; RA Costa M.D., Cherni L., Fernandes V., Freitas F., Ammar El Gaaied A.B., RA Pereira L.; RT "Data from complete mtDNA sequencing of Tunisian centenarians: testing RT haplogroup association and the "golden mean" to longevity."; RL Mech. Ageing Dev. 130:222-226(2009). RN [15] RP NUCLEOTIDE SEQUENCE. RA Peng M.-S., Ho Q.-H., Kong Q.-P., Zhang Y.-P.; RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases. RN [16] RP NUCLEOTIDE SEQUENCE. RA Greenspan B.; RL Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases. RN [17] RP NUCLEOTIDE SEQUENCE. RX PubMed=21176127; DOI=10.1186/1471-2148-10-390; RA Pereira L., Silva N.M., Franco-Duarte R., Fernandes V., Pereira J.B., RA Costa M.D., Martins H., Soares P., Behar D.M., Richards M.B., RA Macaulay V.; RT "Population expansion in the North African late Pleistocene signalled RT by mitochondrial DNA haplogroup U6."; RL BMC Evol. Biol. 10:390-390(2010). RN [18] RP NUCLEOTIDE SEQUENCE. RA Pike D.A., Barton T.J., Bauer S.L., Kipp E.; RT "mtDNA Haplogroup T Phylogeny Based on Full Mitochondrial Sequences."; RL J Genet Geneal 6:1-24(2010). RN [19] RP NUCLEOTIDE SEQUENCE. RX PubMed=20513740; DOI=10.1093/molbev/msq131; RA Peng M.S., Quang H.H., Dang K.P., Trieu A.V., Wang H.W., Yao Y.G., RA Kong Q.P., Zhang Y.P.; RT "Tracing the Austronesian footprint in Mainland Southeast Asia: a RT perspective from mitochondrial DNA."; RL Mol. Biol. Evol. 27:2417-2430(2010). RN [20] RP NUCLEOTIDE SEQUENCE. RX PubMed=20808834; DOI=10.1371/journal.pone.0012295; RA Zaragoza M.V., Fass J., Diegoli M., Lin D., Arbustini E.; RT "Mitochondrial DNA variant discovery and evaluation in human RT Cardiomyopathies through next-generation sequencing."; RL PLoS ONE 5:E12295-E12295(2010). RN [21] RP NUCLEOTIDE SEQUENCE. RX PubMed=21203537; DOI=10.1371/journal.pone.0015214; RA Derenko M., Malyarchuk B., Grzybowski T., Denisova G., Rogalla U., RA Perkova M., Dambueva I., Zakharov I.; RT "Origin and post-glacial dispersal of mitochondrial DNA haplogroups C RT and D in northern Asia."; RL PLoS ONE 5:E15214-E15214(2010). RN [22] RP NUCLEOTIDE SEQUENCE. RA Sharma V., Singh L., Thangaraj K., Nandan A., Sharma V.K.; RT "Phylogenomic study of a concealed Ladakh tribe of the Great RT Himalayas."; RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases. RN [23] RP NUCLEOTIDE SEQUENCE. RA Greenspan B.; RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases. RN [24] RP NUCLEOTIDE SEQUENCE. RA Greenspan B.; RL Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases. RN [25] RP NUCLEOTIDE SEQUENCE. RX PubMed=21978175; DOI=10.1186/1471-2148-11-293; RA Kumar S., Bellis C., Zlojutro M., Melton P.E., Blangero J., RA Curran J.E.; RT "Large scale mitochondrial sequencing in Mexican Americans suggests a RT reappraisal of Native American origins."; RL BMC Evol. Biol. 11:293-293(2011). RN [26] RP NUCLEOTIDE SEQUENCE. RX PubMed=21041797; DOI=10.1093/molbev/msq294; RA Batini C., Lopes J., Behar D.M., Calafell F., Jorde L.B., RA van der Veen L., Quintana-Murci L., Spedini G., Destro-Bisol G., RA Comas D.; RT "Insights into the demographic history of African Pygmies from RT complete mitochondrial genomes."; RL Mol. Biol. Evol. 28:1099-1110(2011). RN [27] RP NUCLEOTIDE SEQUENCE. RX PubMed=21822691; DOI=10.1007/s10072-011-0735-9; RA Reiff D.M., Spathis R., Chan C.W., Vilar M.G., Sankaranarayanan K., RA Lynch D., Ehrlich E., Kerath S., Chowdhury R., Robinowitz L., RA Koji Lum J., Garruto R.M.; RT "Inherited and somatic mitochondrial DNA mutations in Guam amyotrophic RT lateral sclerosis and parkinsonism-dementia."; RL Neurol. Sci. 32:883-892(2011). RN [28] RP NUCLEOTIDE SEQUENCE. RA Greenspan B.; RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases. RN [29] RP NUCLEOTIDE SEQUENCE. RA Greenspan B.; RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases. RN [30] RP NUCLEOTIDE SEQUENCE. RA Greenspan B.; RL Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases. RN [31] RP NUCLEOTIDE SEQUENCE. RA Greenspan B.; RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases. RN [32] RP NUCLEOTIDE SEQUENCE. RA Greenspan B.; RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases. RN [33] RP NUCLEOTIDE SEQUENCE. RX PubMed=22482806; DOI=10.1016/j.ajhg.2012.03.002; RA Behar D.M., van Oven M., Rosset S., Metspalu M., Loogvali E.L., RA Silva N.M., Kivisild T., Torroni A., Villems R.; RT "A "Copernican" reassessment of the human mitochondrial DNA tree from RT its root."; RL Am. J. Hum. Genet. 90:675-684(2012). RN [34] RP NUCLEOTIDE SEQUENCE. RX PubMed=22560092; DOI=10.1016/j.ajhg.2012.04.003; RA Pala M., Olivieri A., Achilli A., Accetturo M., Metspalu E., RA Reidla M., Tamm E., Karmin M., Reisberg T., Hooshiar Kashani B., RA Perego U.A., Carossa V., Gandini F., Pereira J.B., Soares P., RA Angerhofer N., Rychkov S., Al-Zahery N., Carelli V., Sanati M.H., RA Houshmand M., Hatina J., Macaulay V., Pereira L., Woodward S.R., RA Davies W., Gamble C., Baird D., Semino O., Villems R., Torroni A., RA Richards M.B.; RT "Mitochondrial DNA signals of late glacial recolonization of europe RT from near eastern refugia."; RL Am. J. Hum. Genet. 90:915-924(2012). RN [35] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Skeletal muscle; RX PubMed=22258525; DOI=10.1038/ejhg.2011.262; RA van der Walt E.M., Smuts I., Taylor R.W., Elson J.L., Turnbull D.M., RA Louw R., van der Westhuizen F.H.; RT "Characterization of mtDNA variation in a cohort of South African RT paediatric patients with mitochondrial disease."; RL Eur. J. Hum. Genet. 20:650-656(2012). RN [36] RP NUCLEOTIDE SEQUENCE. RX PubMed=22130972; DOI=10.1093/molbev/msr291; RA Barbieri C., Whitten M., Beyer K., Schreiber H., Li M., Pakendorf B.; RT "Contrasting maternal and paternal histories in the linguistic context RT of burkina faso."; RL Mol. Biol. Evol. 29:1213-1223(2012). RN [37] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Esophageal cancerous tissue, and Paracancerous normal RC esophageal tissue; RX PubMed=22130971; DOI=10.1093/molbev/msr290; RA Liu J., Wang L.D., Sun Y.B., Li E.M., Xu L.Y., Zhang Y.P., Yao Y.G., RA Kong Q.P.; RT "Deciphering the signature of selective constraints on cancerous RT mitochondrial genome."; RL Mol. Biol. Evol. 29:1255-1261(2012). RN [38] RP NUCLEOTIDE SEQUENCE. RX PubMed=22729749; DOI=10.1093/molbev/mss169; RG HUGO Pan-Asian SNP Consortium; RA Jinam T.A., Hong L.C., Phipps M.E., Stoneking M., Ameen M., Edo J., RA Saitou N.; RT "Evolutionary history of continental southeast asians: "early train" RT hypothesis based on genetic analysis of mitochondrial and autosomal RT DNA data."; RL Mol. Biol. Evol. 29:3513-3527(2012). RN [39] RP NUCLEOTIDE SEQUENCE. RA Greenspan B.; RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases. RN [40] RP NUCLEOTIDE SEQUENCE. RA Wang H., Zhao M., Sun F., Mitra B., Chaudhuri T.K., Regmi P., Wu S., RA Kong Q., Zhang Y.; RT "Revisiting the Role of the Himalayas in Peopling Nepal: Insights from RT Mitochondrial DNA Genomes."; RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases. RN [41] RP NUCLEOTIDE SEQUENCE. RA Greenspan B.; RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases. RN [42] RP NUCLEOTIDE SEQUENCE. RX PubMed=24341918; RA Raule N., Sevini F., Li S., Barbieri A., Tallaro F., Lomartire L., RA Vianello D., Montesanto A., Moilanen J.S., Bezrukov V., Blanche H., RA Hervonen A., Christensen K., Deiana L., Gonos E.S., Kirkwood T.B., RA Kristensen P., Leon A., Pelicci P.G., Poulain M., Rea I.M., RA Remacle J., Robine J.M., Schreiber S., Sikora E., Eline Slagboom P., RA Spazzafumo L., Antonietta Stazi M., Toussaint O., Vaupel J.W., RA Rose G., Majamaa K., Perola M., Johnson T.E., Bolund L., Yang H., RA Passarino G., Franceschi C.; RT "The co-occurrence of mtDNA mutations on different oxidative RT phosphorylation subunits, not detected by haplogroup analysis, affects RT human longevity and is population specific."; RL Aging Cell 0:0-0(2013). RN [43] RP NUCLEOTIDE SEQUENCE. RA Duggan A.T., Stoneking M.; RT "A Highly Unstable Recent Mutation in Human mtDNA."; RL Am. J. Hum. Genet. 0:0-0(2013). RN [44] RP NUCLEOTIDE SEQUENCE. RX PubMed=24323467; RA Barbieri C., Guldemann T., Naumann C., Gerlach L., Berthold F., RA Nakagawa H., Mpoloka S.W., Stoneking M., Pakendorf B.; RT "Unraveling the complex maternal history of Southern African Khoisan RT populations."; RL Am. J. Phys. Anthropol. 0:0-0(2013). RN [45] RP NUCLEOTIDE SEQUENCE. RX PubMed=23844106; DOI=10.1371/journal.pone.0067835; RA Cardoso S., Valverde L., Alfonso-Sanchez M.A., Palencia-Madrid L., RA Elcoroaristizabal X., Algorta J., Catarino S., Arteta D., RA Herrera R.J., Zarrabeitia M.T., Pena J.A., de Pancorbo M.M.; RT "The Expanded mtDNA Phylogeny of the Franco-Cantabrian Region Upholds RT the Pre-Neolithic Genetic Substrate of Basques."; RL PLoS ONE 8:e67835-e67835(2013). RN [46] RP NUCLEOTIDE SEQUENCE. RX PubMed=24244704; RA Derenko M., Malyarchuk B., Bahmanimehr A., Denisova G., Perkova M., RA Farjadian S., Yepiskoposyan L.; RT "Complete mitochondrial DNA diversity in iranians."; RL PLoS ONE 8:E80673-E80673(2013). RN [47] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Skeletal muscle; RA van der Westhuizen F.H., Schoeman E.M., Smuts I., Elson J., Louw R., RA Taylor R.W., Turnbull D.M.; RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases. RN [48] RP NUCLEOTIDE SEQUENCE. RA Wang H.-W., Zhao M., Sun F., Mitra B., Chaudhuri T.K., Regmi P., RA Wu S., Kong Q., Zhang Y.; RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases. RN [49] RP NUCLEOTIDE SEQUENCE. RA Li S., Schierup M.H.; RT "Variation and association to diabetes in 2000 full mtDNA sequences RT mined from an exome study in a Danish population."; RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases. RN [50] RP NUCLEOTIDE SEQUENCE. RA Ko A.M.-S., Chen C.-Y., Fu Q., Delfin F., Li M., Chiu H.-L., RA Stoneking M., Ko Y.-C.; RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases. RN [51] RP NUCLEOTIDE SEQUENCE. RX PubMed=24607387; DOI=10.1016/j.ajhg.2014.02.003; RA Ko A.M., Chen C.Y., Fu Q., Delfin F., Li M., Chiu H.L., Stoneking M., RA Ko Y.C.; RT "Early austronesians: into and out of taiwan."; RL Am. J. Hum. Genet. 94:426-436(2014). RN [52] RP NUCLEOTIDE SEQUENCE. RX PubMed=24726474; DOI=10.1016/j.ajhg.2014.03.014; RA Duggan A.T., Evans B., Friedlaender F.R., Friedlaender J.S., Koki G., RA Merriwether D.A., Kayser M., Stoneking M.; RT "Maternal History of Oceania from Complete mtDNA Genomes: Contrasting RT Ancient Diversity with Recent Homogenization Due to the Austronesian RT Expansion."; RL Am. J. Hum. Genet. 94:721-733(2014). RN [53] RP NUCLEOTIDE SEQUENCE. RX PubMed=24676463; RA Fregel R., Seetah K., Betancor E., Suarez N.M., Calaon D., Caval S., RA Janoo A., Pestano J.; RT "Multiple ethnic origins of mitochondrial DNA lineages for the RT population of mauritius."; RL PLoS ONE 9:E93294-E93294(2014). RN [54] RP NUCLEOTIDE SEQUENCE. RA Greenspan B.; RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases. RN [55] RP NUCLEOTIDE SEQUENCE. RA Zheng H.-X., Qin Z.-D., Jin L., Jin L.; RT "The mitochondrial DNA diversity of HGDP populations."; RL Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases. RN [56] RP NUCLEOTIDE SEQUENCE. RA Greenspan B.; RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases. RN [57] RP NUCLEOTIDE SEQUENCE. RA Greenspan B.; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory CC chain that catalyzes the reduction of oxygen to water. Subunits 1- CC 3 form the functional core of the enzyme complex. CO I is the CC catalytic subunit of the enzyme. Electrons originating in CC cytochrome c are transferred via the copper A center of subunit 2 CC and heme A of subunit 1 to the bimetallic center formed by heme A3 CC and copper B (By similarity). CC -!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) + 4 H(+) = 4 CC ferricytochrome c + 2 H(2)O. CC -!- PATHWAY: Energy metabolism; oxidative phosphorylation. CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass CC membrane protein (By similarity). CC -!- SIMILARITY: Belongs to the heme-copper respiratory oxidase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ112780; AAZ01010.1; -; Genomic_DNA. DR EMBL; DQ112814; AAZ01452.1; -; Genomic_DNA. DR EMBL; DQ305013; ABB99065.1; -; Genomic_DNA. DR EMBL; DQ305017; ABB99117.1; -; Genomic_DNA. DR EMBL; DQ523629; ABF48862.1; -; Genomic_DNA. DR EMBL; DQ523633; ABF48914.1; -; Genomic_DNA. DR EMBL; DQ523667; ABF49356.1; -; Genomic_DNA. DR EMBL; EF222243; ABM68794.1; -; Genomic_DNA. DR EMBL; EF222244; ABM68807.1; -; Genomic_DNA. DR EMBL; EF556160; ABP99220.1; -; Genomic_DNA. DR EMBL; EF556164; ABP99272.1; -; Genomic_DNA. DR EMBL; EF660941; ABR57901.1; -; Genomic_DNA. DR EMBL; EF657314; ABR94049.1; -; Genomic_DNA. DR EMBL; EF657390; ABR95035.1; -; Genomic_DNA. DR EMBL; EF657506; ABR96541.1; -; Genomic_DNA. DR EMBL; EF657599; ABR97747.1; -; Genomic_DNA. DR EMBL; EU545449; ACA80812.1; -; Genomic_DNA. DR EMBL; FJ445407; ACJ36278.1; -; Genomic_DNA. DR EMBL; FJ460526; ACJ47314.1; -; Genomic_DNA. DR EMBL; FJ951612; ACQ76169.1; -; Genomic_DNA. DR EMBL; GQ301876; ACT15804.1; -; Genomic_DNA. DR EMBL; GU048747; ACX93187.1; -; Genomic_DNA. DR EMBL; HM627754; ADK47694.1; -; Genomic_DNA. DR EMBL; HM765471; ADK66661.1; -; Genomic_DNA. DR EMBL; HM036564; ADK73092.1; -; Genomic_DNA. DR EMBL; HM036567; ADK73131.1; -; Genomic_DNA. DR EMBL; HM771231; ADL16364.1; -; Genomic_DNA. DR EMBL; HQ012167; ADM60114.1; -; Genomic_DNA. DR EMBL; HQ658466; ADR50454.1; -; Genomic_DNA. DR EMBL; HQ651704; ADU77849.1; -; Genomic_DNA. DR EMBL; HQ700846; ADV38424.1; -; Genomic_DNA. DR EMBL; JF892552; AEE11546.1; -; Genomic_DNA. DR EMBL; JF833037; AEE11715.1; -; Genomic_DNA. DR EMBL; JF951723; AEF12449.1; -; Genomic_DNA. DR EMBL; JF824836; AEG62418.1; -; Genomic_DNA. DR EMBL; JF824929; AEG63627.1; -; Genomic_DNA. DR EMBL; JF742198; AEH03887.1; -; Genomic_DNA. DR EMBL; JN037468; AEH05284.1; -; Genomic_DNA. DR EMBL; JN202494; AEJ82365.1; -; Genomic_DNA. DR EMBL; JN232198; AEK26984.1; -; Genomic_DNA. DR EMBL; JN252308; AEK26997.1; -; Genomic_DNA. DR EMBL; JN580589; AEM64428.1; -; Genomic_DNA. DR EMBL; JN969984; AET11505.1; -; Genomic_DNA. DR EMBL; JQ044972; AEV49205.1; -; Genomic_DNA. DR EMBL; JQ045103; AEV50908.1; -; Genomic_DNA. DR EMBL; JQ701934; AFF63102.1; -; Genomic_DNA. DR EMBL; JQ702795; AFF74295.1; -; Genomic_DNA. DR EMBL; JQ702928; AFF76024.1; -; Genomic_DNA. DR EMBL; JQ703030; AFF77350.1; -; Genomic_DNA. DR EMBL; JQ703068; AFF77844.1; -; Genomic_DNA. DR EMBL; JQ703391; AFF82043.1; -; Genomic_DNA. DR EMBL; JQ703586; AFF84578.1; -; Genomic_DNA. DR EMBL; JQ703687; AFF85891.1; -; Genomic_DNA. DR EMBL; JQ703691; AFF85943.1; -; Genomic_DNA. DR EMBL; JQ703757; AFF86801.1; -; Genomic_DNA. DR EMBL; JQ703823; AFF87659.1; -; Genomic_DNA. DR EMBL; JQ704020; AFF90220.1; -; Genomic_DNA. DR EMBL; JQ704073; AFF90909.1; -; Genomic_DNA. DR EMBL; JQ704293; AFF93769.1; -; Genomic_DNA. DR EMBL; JQ704341; AFF94393.1; -; Genomic_DNA. DR EMBL; JQ704559; AFF97227.1; -; Genomic_DNA. DR EMBL; JQ704803; AFG00400.1; -; Genomic_DNA. DR EMBL; JQ704931; AFG02063.1; -; Genomic_DNA. DR EMBL; JQ705472; AFG09096.1; -; Genomic_DNA. DR EMBL; JQ705571; AFG10383.1; -; Genomic_DNA. DR EMBL; JQ705668; AFG11644.1; -; Genomic_DNA. DR EMBL; JQ705678; AFG11774.1; -; Genomic_DNA. DR EMBL; JQ796696; AFG26670.1; -; Genomic_DNA. DR EMBL; JQ798091; AFI53933.1; -; Genomic_DNA. DR EMBL; JQ798092; AFI53946.1; -; Genomic_DNA. DR EMBL; JQ798093; AFI53959.1; -; Genomic_DNA. DR EMBL; JQ798094; AFI53972.1; -; Genomic_DNA. DR EMBL; JQ798095; AFI53985.1; -; Genomic_DNA. DR EMBL; JQ798096; AFI53998.1; -; Genomic_DNA. DR EMBL; JQ798098; AFI54024.1; -; Genomic_DNA. DR EMBL; JQ798099; AFI54037.1; -; Genomic_DNA. DR EMBL; JQ798100; AFI54050.1; -; Genomic_DNA. DR EMBL; JQ798101; AFI54063.1; -; Genomic_DNA. DR EMBL; JQ798102; AFI54076.1; -; Genomic_DNA. DR EMBL; JQ798103; AFI54089.1; -; Genomic_DNA. DR EMBL; JX152808; AFO20679.1; -; Genomic_DNA. DR EMBL; JX153174; AFO25437.1; -; Genomic_DNA. DR EMBL; JX153298; AFO27049.1; -; Genomic_DNA. DR EMBL; JX153536; AFO30143.1; -; Genomic_DNA. DR EMBL; JX153694; AFO32197.1; -; Genomic_DNA. DR EMBL; JX153740; AFO32795.1; -; Genomic_DNA. DR EMBL; JX153910; AFO35005.1; -; Genomic_DNA. DR EMBL; JX297170; AFP98377.1; -; Genomic_DNA. DR EMBL; JX494787; AFQ92158.1; -; Genomic_DNA. DR EMBL; JX900736; AGC20584.1; -; Genomic_DNA. DR EMBL; JX900740; AGC20636.1; -; Genomic_DNA. DR EMBL; JX900752; AGC20792.1; -; Genomic_DNA. DR EMBL; JX900814; AGC21598.1; -; Genomic_DNA. DR EMBL; JX900818; AGC21650.1; -; Genomic_DNA. DR EMBL; JX900820; AGC21676.1; -; Genomic_DNA. DR EMBL; KC577360; AGI49209.1; -; Genomic_DNA. DR EMBL; KC622055; AGJ95189.1; -; Genomic_DNA. DR EMBL; KC622132; AGJ96190.1; -; Genomic_DNA. DR EMBL; KC533463; AGK64259.1; -; Genomic_DNA. DR EMBL; KC911358; AGO91396.1; -; Genomic_DNA. DR EMBL; KC911377; AGO91643.1; -; Genomic_DNA. DR EMBL; KC911528; AGO93606.1; -; Genomic_DNA. DR EMBL; KC911610; AGO94672.1; -; Genomic_DNA. DR EMBL; KF161296; AGW57416.1; -; Genomic_DNA. DR EMBL; KF161581; AGW61120.1; -; Genomic_DNA. DR EMBL; KF161591; AGW61250.1; -; Genomic_DNA. DR EMBL; KF161680; AGW62407.1; -; Genomic_DNA. DR EMBL; KF161710; AGW62797.1; -; Genomic_DNA. DR EMBL; KF161987; AGW66398.1; -; Genomic_DNA. DR EMBL; KF162009; AGW66684.1; -; Genomic_DNA. DR EMBL; KF162443; AGW72326.1; -; Genomic_DNA. DR EMBL; KF162449; AGW72404.1; -; Genomic_DNA. DR EMBL; KF162505; AGW73132.1; -; Genomic_DNA. DR EMBL; KF162518; AGW73301.1; -; Genomic_DNA. DR EMBL; KF162639; AGW74874.1; -; Genomic_DNA. DR EMBL; KF162822; AGW77253.1; -; Genomic_DNA. DR EMBL; KF541018; AGZ12528.1; -; Genomic_DNA. DR EMBL; KF541029; AGZ12671.1; -; Genomic_DNA. DR EMBL; KF541040; AGZ12814.1; -; Genomic_DNA. DR EMBL; KJ371984; AHJ59896.1; -; Genomic_DNA. DR EMBL; KJ631751; AHN65769.1; -; Genomic_DNA. DR EMBL; KJ154197; AHW30222.1; -; Genomic_DNA. DR EMBL; KJ154235; AHW30716.1; -; Genomic_DNA. DR EMBL; KJ154404; AHW32913.1; -; Genomic_DNA. DR EMBL; KJ154435; AHW33316.1; -; Genomic_DNA. DR EMBL; KJ445826; AHX43794.1; -; Genomic_DNA. DR EMBL; KJ445827; AHX43807.1; -; Genomic_DNA. DR EMBL; KJ445828; AHX43820.1; -; Genomic_DNA. DR EMBL; KJ445938; AHX45250.1; -; Genomic_DNA. DR EMBL; KJ446543; AHX53115.1; -; Genomic_DNA. DR EMBL; KJ756350; AHY82702.1; -; Genomic_DNA. DR EMBL; AP008278; BAE07599.1; -; Genomic_DNA. DR EMBL; AP008776; BAE14075.1; -; Genomic_DNA. DR EMBL; AP008896; BAE15635.1; -; Genomic_DNA. DR EMBL; AP012349; BAM25111.1; -; Genomic_DNA. DR HOVERGEN; HBG003841; -. DR UniPathway; UPA00705; -. DR NextBio; 35538713; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW. DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC. DR GO; GO:0020037; F:heme binding; IEA:InterPro. DR GO; GO:0005506; F:iron ion binding; IEA:InterPro. DR GO; GO:0009060; P:aerobic respiration; IEA:InterPro. DR GO; GO:0006119; P:oxidative phosphorylation; IEA:UniProtKB-UniPathway. DR Gene3D; 1.20.210.10; -; 1. DR InterPro; IPR000883; COX1. DR InterPro; IPR023615; Cyt_c_Oxase_su1_BS. DR InterPro; IPR023616; Cyt_c_Oxase_su1_dom. DR PANTHER; PTHR10422; PTHR10422; 1. DR Pfam; PF00115; COX1; 1. DR PRINTS; PR01165; CYCOXIDASEI. DR SUPFAM; SSF81442; SSF81442; 1. DR PROSITE; PS50855; COX1; 1. DR PROSITE; PS00077; COX1_CUB; 1. PE 3: Inferred from homology; KW Copper; Electron transport; Heme; Iron; Membrane; Metal-binding; KW Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; KW Respiratory chain; Transmembrane; Transport. SQ SEQUENCE 513 AA; 57071 MW; AC5769A5F6E4FE47 CRC64; MFADRWLFST NHKDIGTLYL LFGAWAGVLG TALSLLIRAE LGQPGNLLGN DHIYNVIVTA HAFVMIFFMV MPIMIGGFGN WLVPLMIGAP DMAFPRMNNM SFWLLPPSLL LLLASAMVET GAGTGWTVYP PLAGNYSHPG ASVDLTIFSL HLAGVSSILG AINFITTIIN MKPPAMTQYQ TPLFVWSVLI TAVLLLLSLP VLAAGITMLL TDRNLNTTFF DPAGGGDPIL YQHLFWFFGH PEVYILILPG FGMISHIVTY YSGKKEPFGY MGMVWAMMSI GFLGFIVWAH HMFTVGMDVD TRAYFTSATM IIAIPTGVKV FSWLATLHGS NMKWSAAVLW ALGFIFLFTV GGLTGIVLAN SSLDIVLHDT YYVVAHFHYV LSMGAVFAIM GGFIHWFPLF SGYTLDQTYA KIHFTIMFIG VNLTFFPQHF LGLSGMPRRY SDYPDAYTTW NILSSVGSFI SLTAVMLMIF MIWEAFASKR KVLMVEEPSM NLEWLYGCPP PYHTFEEPVY MKS //