ID Q4G6P4_HUMAN Unreviewed; 261 AA. AC Q4G6P4; DT 30-AUG-2005, integrated into UniProtKB/TrEMBL. DT 30-AUG-2005, sequence version 1. DT 07-NOV-2018, entry version 84. DE RecName: Full=Cytochrome c oxidase subunit 3 {ECO:0000256|RuleBase:RU003375}; GN Name=COIII {ECO:0000313|EMBL:BAE15899.1}; GN Synonyms=COX3 {ECO:0000313|EMBL:ABN13452.2}; OS Homo sapiens (Human). OG Mitochondrion {ECO:0000313|EMBL:BAE15899.1}. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAE15899.1}; RN [1] {ECO:0000313|EMBL:BAE15899.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=JDsq0100 {ECO:0000313|EMBL:BAE15899.1}, and NDsq0117 RC {ECO:0000313|EMBL:BAE14092.1}; RX PubMed=15466285; DOI=10.1101/gr.2286304; RA Tanaka M., Cabrera V.M., Gonzalez A.M., Larruga J.M., Takeyasu T., RA Fuku N., Guo L., Hirose R., Fujita Y., Kurata M., Shinoda K., RA Umetsu K., Yamada Y., Oshida Y., Sato Y., Hattori N., Mizuno Y., RA Arai Y., Hirose N., Ohta S., Ogawa O., Tanaka Y., Kawamori R., RA Shamoto-Nagai M., Maruyama W., Shimokata H., Suzuki R., Shimodaira H.; RT "Mitochondrial genome variation in eastern Asia and the peopling of RT Japan."; RL Genome Res. 14:1832-1850(2004). RN [2] {ECO:0000313|EMBL:BAE14092.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=NDsq0117 {ECO:0000313|EMBL:BAE14092.1}; RA Guo L., Oshida Y., Fuku N., Takeyasu T., Fujita Y., Kurata M., RA Sato Y., Ito M., Tanaka M.; RT "Mitochondrial genome polymorphisms associated with type-2 diabetes or RT obesity."; RL Mitochondrion 0:0-0(2004). RN [3] {ECO:0000313|EMBL:BAG39298.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mdmd46 {ECO:0000313|EMBL:BAG39298.1}; RX PubMed=16048457; DOI=10.1111/j.1440-1819.2005.01404.x; RA Kazuno A., Munakata K., Mori K., Tanaka M., Nanko S., Kunugi H., RA Umekage T., Tochigi M., Kohda K., Sasaki T., Akiyama T., Washizuka S., RA Kato N., Kato T.; RT "Mitochondrial DNA sequence analysis of patients with 'atypical RT psychosis'."; RL Psychiatry Clin. Neurosci. 59:497-503(2005). RN [4] {ECO:0000313|EMBL:BAE15899.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=JDsq0100 {ECO:0000313|EMBL:BAE15899.1}, and NDsq0117 RC {ECO:0000313|EMBL:BAE14092.1}; RA Tanaka M.; RT "Human mitochondrial genome polymorphism database (mtSNP)."; RL Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|EMBL:BAG39298.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mdmd46 {ECO:0000313|EMBL:BAG39298.1}; RX PubMed=16895436; DOI=10.1371/journal.pgen.0020128; RA Kazuno A., Munakata K., Nagai T., Shimozono S., Tanaka M., Yoneda M., RA Kato N., Miyawaki A., Kato T.; RT "Identification of mitochondrial DNA polymorphisms that alter RT mitochondrial matrix pH and intracellular calcium dynamics."; RL PLoS Genet. 2:e128-e128(2006). RN [6] {ECO:0000313|EMBL:ABN13452.2} RP NUCLEOTIDE SEQUENCE. RA Greenspan B.; RL Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:BAG39298.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mdmd46 {ECO:0000313|EMBL:BAG39298.1}; RA Kazuno A., Munakata K., Mori K., Nanko S., Kunugi H., Nakamura K., RA Mori N., Yamada K., Yoshikawa T., Kato N., Kato T.; RT "Mitochondrial DNA haplogroup analysis in patients with Bipolar RT Disorder."; RL Am. J. Med. Genet. B Neuropsychiatr. Genet. 0:0-0(2008). RN [8] {ECO:0000313|EMBL:BAG39298.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mdmd46 {ECO:0000313|EMBL:BAG39298.1}; RX PubMed=17288645; RA Kazuno A., Munakata K., Kato N., Kato T.; RT "Mitochondrial DNA-dependent effects of valproate on mitochondrial RT calcium levels in transmitochondrial cybrids."; RL Int. J. Neuropsychopharmacol. 11:71-78(2008). RN [9] {ECO:0000313|EMBL:BAG39298.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mdmd46 {ECO:0000313|EMBL:BAG39298.1}; RX PubMed=18226984; DOI=10.1016/j.mito.2007.12.002; RA Kazuno A., Munakata K., Tanaka M., Kato N., Kato T.; RT "Relationships between mitochondrial DNA subhaplogroups and RT intracellular calcium dynamics."; RL Mitochondrion 8:164-169(2008). RN [10] {ECO:0000313|EMBL:ADL15367.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=21041797; DOI=10.1093/molbev/msq294; RA Batini C., Lopes J., Behar D.M., Calafell F., Jorde L.B., RA van der Veen L., Quintana-Murci L., Spedini G., Destro-Bisol G., RA Comas D.; RT "Insights into the demographic history of African Pygmies from RT complete mitochondrial genomes."; RL Mol. Biol. Evol. 28:1099-1110(2011). RN [11] {ECO:0000313|EMBL:AFV56906.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Saliva {ECO:0000313|EMBL:AFV56906.1}; RA Tito R.Y., Polo S.I., Lewis C.M.Jr.; RT "Mitochondrial Genomes and Founder Effects within the Americas."; RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases. RN [12] {ECO:0000313|EMBL:AGH20733.1} RP NUCLEOTIDE SEQUENCE. RA Greenspan B.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [13] {ECO:0000313|EMBL:AGZ66938.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=25254093; DOI=10.1186/2041-2223-5-13; RA Lippold S., Xu H., Ko A., Li M., Renaud G., Butthof A., Schroder R., RA Stoneking M.; RT "Human paternal and maternal demographic histories: insights from RT high-resolution Y chromosome and mtDNA sequences."; RL Investig Genet 5:13-13(2014). RN [14] {ECO:0000313|EMBL:AHX43278.1} RP NUCLEOTIDE SEQUENCE. RA Zheng H.-X., Qin Z.-D., Jin L., Jin L.; RT "The mitochondrial DNA diversity of HGDP populations."; RL Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases. RN [15] {ECO:0000313|EMBL:AKH35845.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26640946; RA De Fanti S., Barbieri C., Sarno S., Sevini F., Vianello D., Tamm E., RA Metspalu E., van Oven M., Hubner A., Sazzini M., Franceschi C., RA Pettener D., Luiselli D.; RT "Fine Dissection of Human Mitochondrial DNA Haplogroup HV Lineages RT Reveals Paleolithic Signatures from European Glacial Refugia."; RL PLoS ONE 10:E0144391-E0144391(2015). RN [16] {ECO:0000313|EMBL:ASS04564.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=28716916; DOI=.1073/pnas.1704906114; RA Pierron D., Heiske M., Razafindrazaka H., Rakoto I., Rabetokotany N., RA Ravololomanga B., Rakotozafy L.M., Rakotomalala M.M., RA Razafiarivony M., Rasoarifetra B., Raharijesy M.A., RA Razafindralambo L., Ramilisonina, Fanony F., Lejamble S., Thomas O., RA Mohamed Abdallah A., Rocher C., Arachiche A., Tonaso L., RA Pereda-Loth V., Schiavinato S., Brucato N., Ricaut F.X., Kusuma P., RA Sudoyo H., Ni S., Boland A., Deleuze J.F., Beaujard P., Grange P., RA Adelaar S., Stoneking M., Rakotoarisoa J.A., Radimilahy C., RA Letellier T.; RT "Genomic landscape of human diversity across Madagascar."; RL Proc. Natl. Acad. Sci. U.S.A. 114:E6498-E6506(2017). RN [17] {ECO:0000313|EMBL:ASU93649.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Peripheral blood {ECO:0000313|EMBL:ASU93649.1}; RA Afonso C.L., Miller P.J., Scott M.A., Spackman E., Goraichik I., RA Dimitrov K.M., Suarez D.L., Swayne D.E.; RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases. RN [18] {ECO:0000313|EMBL:ATW75525.1} RP NUCLEOTIDE SEQUENCE. RA Han C.G.; RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Subunits I, II and III form the functional core of the CC enzyme complex. {ECO:0000256|RuleBase:RU003375}. CC -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 3 family. CC {ECO:0000256|RuleBase:RU003375, ECO:0000256|SAAS:SAAS00709834}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; EF417833; ABN13452.2; -; Genomic_DNA. DR EMBL; HM771154; ADL15367.1; -; Genomic_DNA. DR EMBL; HM771155; ADL15380.1; -; Genomic_DNA. DR EMBL; JX669399; AFV56906.1; -; Genomic_DNA. DR EMBL; KC765917; AGH20733.1; -; Genomic_DNA. DR EMBL; KF451023; AGZ66938.1; -; Genomic_DNA. DR EMBL; KF451033; AGZ67068.1; -; Genomic_DNA. DR EMBL; KJ445786; AHX43278.1; -; Genomic_DNA. DR EMBL; KJ445787; AHX43291.1; -; Genomic_DNA. DR EMBL; KP340171; AKH35845.1; -; Genomic_DNA. DR EMBL; MF056587; ASS04564.1; -; Genomic_DNA. DR EMBL; KY941906; ASU93649.1; -; Genomic_DNA. DR EMBL; MG546008; ATW75525.1; -; Genomic_DNA. DR EMBL; AP008777; BAE14092.1; -; Genomic_DNA. DR EMBL; AP008916; BAE15899.1; -; Genomic_DNA. DR EMBL; AP009464; BAG39298.1; -; Genomic_DNA. DR eggNOG; KOG4664; Eukaryota. DR eggNOG; COG1845; LUCA. DR HOVERGEN; HBG016686; -. DR ChiTaRS; COX3; human. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW. DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:InterPro. DR GO; GO:0019646; P:aerobic electron transport chain; IEA:InterPro. DR CDD; cd01665; Cyt_c_Oxidase_III; 1. DR Gene3D; 1.20.120.80; -; 1. DR InterPro; IPR024791; Cyt_c/ubiquinol_Oxase_su3. DR InterPro; IPR033945; Cyt_c_oxase_su3_dom. DR InterPro; IPR000298; Cyt_c_oxidase-like_su3. DR InterPro; IPR035973; Cyt_c_oxidase_su3-like_sf. DR InterPro; IPR013833; Cyt_c_oxidase_su3_a-hlx. DR PANTHER; PTHR11403; PTHR11403; 1. DR Pfam; PF00510; COX3; 1. DR SUPFAM; SSF81452; SSF81452; 1. DR PROSITE; PS50253; COX3; 1. PE 3: Inferred from homology; KW Membrane {ECO:0000256|SAAS:SAAS00709742, ECO:0000256|SAM:Phobius}; KW Mitochondrion {ECO:0000256|RuleBase:RU003375, KW ECO:0000313|EMBL:BAE15899.1}; KW Transmembrane {ECO:0000256|RuleBase:RU003375, KW ECO:0000256|SAAS:SAAS00709762, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00709799, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 16 35 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 41 58 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 79 102 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 159 177 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 197 220 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 240 260 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 4 261 COX3. {ECO:0000259|PROSITE:PS50253}. SQ SEQUENCE 261 AA; 29924 MW; 0DA1A437A7A55B31 CRC64; MTHQSHAYHM VKPSPWPLTG ALSALLMTSG LAMWFHFHSM TLLMLGLLTS TLTMYQWWRD VTRESTYQGH HTPPVQKGLR YGMILFITSE VFFFAGFFWA FYHSSLAPTP QLGGHWPPTG ITPLNPLEVP LLNTSVLLAS GVSITWAHHS LMENNRNQMI QALLITILLG LYFTLLQASE YFESPFTISD GIYGSTFFVA TGFHGLHVII GSTFLTICFI RQLMFHFTSK HHFGFEAAAW YWHFVDVVWL FLYVSIYWWG S //