ID   Q4G6P4_HUMAN            Unreviewed;       261 AA.
AC   Q4G6P4;
DT   30-AUG-2005, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2005, sequence version 1.
DT   04-FEB-2015, entry version 67.
DE   RecName: Full=Cytochrome c oxidase subunit 3 {ECO:0000256|RuleBase:RU003375};
GN   Name=COIII {ECO:0000313|EMBL:BAE15899.1};
GN   Synonyms=COX3 {ECO:0000313|EMBL:ABN13452.2};
OS   Homo sapiens (Human).
OG   Mitochondrion {ECO:0000313|EMBL:BAE15899.1}.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAE15899.1};
RN   [1] {ECO:0000313|EMBL:BAE15899.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=JDsq0100 {ECO:0000313|EMBL:BAE15899.1}, and NDsq0117
RC   {ECO:0000313|EMBL:BAE14092.1};
RX   PubMed=15466285; DOI=10.1101/gr.2286304;
RA   Tanaka M., Cabrera V.M., Gonzalez A.M., Larruga J.M., Takeyasu T.,
RA   Fuku N., Guo L., Hirose R., Fujita Y., Kurata M., Shinoda K.,
RA   Umetsu K., Yamada Y., Oshida Y., Sato Y., Hattori N., Mizuno Y.,
RA   Arai Y., Hirose N., Ohta S., Ogawa O., Tanaka Y., Kawamori R.,
RA   Shamoto-Nagai M., Maruyama W., Shimokata H., Suzuki R., Shimodaira H.;
RT   "Mitochondrial genome variation in eastern Asia and the peopling of
RT   Japan.";
RL   Genome Res. 14:1832-1850(2004).
RN   [2] {ECO:0000313|EMBL:BAE14092.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NDsq0117 {ECO:0000313|EMBL:BAE14092.1};
RA   Guo L., Oshida Y., Fuku N., Takeyasu T., Fujita Y., Kurata M.,
RA   Sato Y., Ito M., Tanaka M.;
RT   "Mitochondrial genome polymorphisms associated with type-2 diabetes or
RT   obesity.";
RL   Mitochondrion 0:0-0(2004).
RN   [3] {ECO:0000313|EMBL:BAG39298.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Mdmd46 {ECO:0000313|EMBL:BAG39298.1};
RX   PubMed=16048457; DOI=10.1111/j.1440-1819.2005.01404.x;
RA   Kazuno A., Munakata K., Mori K., Tanaka M., Nanko S., Kunugi H.,
RA   Umekage T., Tochigi M., Kohda K., Sasaki T., Akiyama T., Washizuka S.,
RA   Kato N., Kato T.;
RT   "Mitochondrial DNA sequence analysis of patients with 'atypical
RT   psychosis'.";
RL   Psychiatry Clin. Neurosci. 59:497-503(2005).
RN   [4] {ECO:0000313|EMBL:BAE15899.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=JDsq0100 {ECO:0000313|EMBL:BAE15899.1}, and NDsq0117
RC   {ECO:0000313|EMBL:BAE14092.1};
RA   Tanaka M.;
RT   "Human mitochondrial genome polymorphism database (mtSNP).";
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EMBL:BAG39298.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Mdmd46 {ECO:0000313|EMBL:BAG39298.1};
RX   PubMed=16895436; DOI=10.1371/journal.pgen.0020128;
RA   Kazuno A., Munakata K., Nagai T., Shimozono S., Tanaka M., Yoneda M.,
RA   Kato N., Miyawaki A., Kato T.;
RT   "Identification of mitochondrial DNA polymorphisms that alter
RT   mitochondrial matrix pH and intracellular calcium dynamics.";
RL   PLoS Genet. 2:e128-e128(2006).
RN   [6] {ECO:0000313|EMBL:ABN13452.2}
RP   NUCLEOTIDE SEQUENCE.
RA   Greenspan B.;
RL   Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|EMBL:BAG39298.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Mdmd46 {ECO:0000313|EMBL:BAG39298.1};
RA   Kazuno A., Munakata K., Mori K., Nanko S., Kunugi H., Nakamura K.,
RA   Mori N., Yamada K., Yoshikawa T., Kato N., Kato T.;
RT   "Mitochondrial DNA haplogroup analysis in patients with Bipolar
RT   Disorder.";
RL   Am. J. Med. Genet. B Neuropsychiatr. Genet. 0:0-0(2008).
RN   [8] {ECO:0000313|EMBL:BAG39298.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Mdmd46 {ECO:0000313|EMBL:BAG39298.1};
RX   PubMed=17288645;
RA   Kazuno A., Munakata K., Kato N., Kato T.;
RT   "Mitochondrial DNA-dependent effects of valproate on mitochondrial
RT   calcium levels in transmitochondrial cybrids.";
RL   Int. J. Neuropsychopharmacol. 11:71-78(2008).
RN   [9] {ECO:0000313|EMBL:BAG39298.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Mdmd46 {ECO:0000313|EMBL:BAG39298.1};
RX   PubMed=18226984; DOI=10.1016/j.mito.2007.12.002;
RA   Kazuno A., Munakata K., Tanaka M., Kato N., Kato T.;
RT   "Relationships between mitochondrial DNA subhaplogroups and
RT   intracellular calcium dynamics.";
RL   Mitochondrion 8:164-169(2008).
RN   [10] {ECO:0000313|EMBL:ADL15367.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=21041797; DOI=10.1093/molbev/msq294;
RA   Batini C., Lopes J., Behar D.M., Calafell F., Jorde L.B.,
RA   van der Veen L., Quintana-Murci L., Spedini G., Destro-Bisol G.,
RA   Comas D.;
RT   "Insights into the demographic history of African Pygmies from
RT   complete mitochondrial genomes.";
RL   Mol. Biol. Evol. 28:1099-1110(2011).
RN   [11] {ECO:0000313|EMBL:AFV56906.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Saliva {ECO:0000313|EMBL:AFV56906.1};
RA   Tito R.Y., Polo S.I., Lewis C.M.Jr.;
RT   "Mitochondrial Genomes and Founder Effects within the Americas.";
RL   Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
RN   [12] {ECO:0000313|EMBL:AGH20733.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Greenspan B.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [13] {ECO:0000313|EMBL:AGZ66938.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25254093; DOI=10.1186/2041-2223-5-13;
RA   Lippold S., Xu H., Ko A., Li M., Renaud G., Butthof A., Schroder R.,
RA   Stoneking M.;
RT   "Human paternal and maternal demographic histories: insights from
RT   high-resolution Y chromosome and mtDNA sequences.";
RL   Investig Genet 5:13-13(2014).
RN   [14] {ECO:0000313|EMBL:AHX43278.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Zheng H.-X., Qin Z.-D., Jin L., Jin L.;
RT   "The mitochondrial DNA diversity of HGDP populations.";
RL   Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Subunits I, II and III form the functional core of the
CC       enzyme complex. {ECO:0000256|RuleBase:RU003375}.
CC   -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 3 family.
CC       {ECO:0000256|RuleBase:RU003375}.
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DR   EMBL; EF417833; ABN13452.2; -; Genomic_DNA.
DR   EMBL; HM771154; ADL15367.1; -; Genomic_DNA.
DR   EMBL; HM771155; ADL15380.1; -; Genomic_DNA.
DR   EMBL; JX669399; AFV56906.1; -; Genomic_DNA.
DR   EMBL; KC765917; AGH20733.1; -; Genomic_DNA.
DR   EMBL; KF451023; AGZ66938.1; -; Genomic_DNA.
DR   EMBL; KF451033; AGZ67068.1; -; Genomic_DNA.
DR   EMBL; KJ445786; AHX43278.1; -; Genomic_DNA.
DR   EMBL; KJ445787; AHX43291.1; -; Genomic_DNA.
DR   EMBL; AP008777; BAE14092.1; -; Genomic_DNA.
DR   EMBL; AP008916; BAE15899.1; -; Genomic_DNA.
DR   EMBL; AP009464; BAG39298.1; -; Genomic_DNA.
DR   ProteinModelPortal; Q4G6P4; -.
DR   SMR; Q4G6P4; 1-261.
DR   HOVERGEN; HBG016686; -.
DR   NextBio; 35538705; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:InterPro.
DR   GO; GO:0019646; P:aerobic electron transport chain; IEA:InterPro.
DR   Gene3D; 1.20.120.80; -; 1.
DR   InterPro; IPR024791; Cyt_c/ubiquinol_Oxase_su3.
DR   InterPro; IPR013833; Cyt_c_oxidase_su3_a-hlx.
DR   InterPro; IPR000298; Cyt_c_oxidase_su3_dom.
DR   PANTHER; PTHR11403; PTHR11403; 1.
DR   Pfam; PF00510; COX3; 1.
DR   SUPFAM; SSF81452; SSF81452; 1.
DR   PROSITE; PS50253; COX3; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|RuleBase:RU003375};
KW   Mitochondrion {ECO:0000256|RuleBase:RU003375,
KW   ECO:0000313|EMBL:BAE15899.1};
KW   Transmembrane {ECO:0000256|RuleBase:RU003375}.
SQ   SEQUENCE   261 AA;  29924 MW;  0DA1A437A7A55B31 CRC64;
     MTHQSHAYHM VKPSPWPLTG ALSALLMTSG LAMWFHFHSM TLLMLGLLTS TLTMYQWWRD
     VTRESTYQGH HTPPVQKGLR YGMILFITSE VFFFAGFFWA FYHSSLAPTP QLGGHWPPTG
     ITPLNPLEVP LLNTSVLLAS GVSITWAHHS LMENNRNQMI QALLITILLG LYFTLLQASE
     YFESPFTISD GIYGSTFFVA TGFHGLHVII GSTFLTICFI RQLMFHFTSK HHFGFEAAAW
     YWHFVDVVWL FLYVSIYWWG S
//