ID Q4G6P4_HUMAN Unreviewed; 261 AA. AC Q4G6P4; DT 30-AUG-2005, integrated into UniProtKB/TrEMBL. DT 30-AUG-2005, sequence version 1. DT 22-JUL-2008, entry version 21. DE RecName: Full=Cytochrome c oxidase subunit 3; GN Name=COIII; Synonyms=COX3; OS Homo sapiens (Human). OG Mitochondrion. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=JDsq0100, and NDsq0117; RX PubMed=15466285; DOI=10.1101/gr.2286304; RA Tanaka M., Cabrera V.M., Gonzalez A.M., Larruga J.M., Takeyasu T., RA Fuku N., Guo L.J., Hirose R., Fujita Y., Kurata M., Shinoda K., RA Umetsu K., Yamada Y., Oshida Y., Sato Y., Hattori N., Mizuno Y., RA Arai Y., Hirose N., Ohta S., Ogawa O., Tanaka Y., Kawamori R., RA Shamoto-Nagai M., Maruyama W., Shimokata H., Suzuki R., Shimodaira H.; RT "Mitochondrial genome variation in eastern Asia and the peopling of RT Japan."; RL Genome Res. 14:1832-1850(2004). RN [2] RP NUCLEOTIDE SEQUENCE. RC STRAIN=JDsq0100, and NDsq0117; RA Tanaka M.; RT "Human mitochondrial genome polymorphism database (mtSNP)."; RL Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mdmd46; RX PubMed=16048457; DOI=10.1111/j.1440-1819.2005.01404.x; RA Kazuno A., Munakata K., Mori K., Tanaka M., Nanko S., Kunugi H., RA Umekage T., Tochigi M., Kohda K., Sasaki T., Akiyama T., Washizuka S., RA Kato N., Kato T.; RT "Mitochondrial DNA sequence analysis of patients with 'atypical RT psychosis'."; RL Psychiatry Clin. Neurosci. 59:497-503(2005). RN [4] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mdmd46; RX PubMed=17288645; RA Kazuno A., Munakata K., Kato N., Kato T.; RT "Mitochondrial DNA-dependent effects of valproate on mitochondrial RT calcium levels in transmitochondrial cybrids."; RL Int. J. Neuropsychopharmacol. 11:71-78(2008). RN [5] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mdmd46; RX PubMed=18226984; DOI=10.1016/j.mito.2007.12.002; RA Kazuno A., Munakata K., Tanaka M., Kato N., Kato T.; RT "Relationships between mitochondrial DNA subhaplogroups and RT intracellular calcium dynamics."; RL Mitochondrion 8:164-169(2008). RN [6] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mdmd46; RA Kazuno A., Munakata K., Mori K., Nanko S., Kunugi H., Nakamura K., RA Mori N., Yamada K., Yoshikawa T., Kato N., Kato T.; RT "Mitochondrial DNA haplogroup analysis in patients with Bipolar RT Disorder."; RL Am. J. Med. Genet. B Neuropsychiatr. Genet. 0:0-0(2008). RN [7] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mdmd46; RA Kazuno A., Munakata K., Nagai T., Shimozono S., Tanaka M., Yoneda M., RA Kato N., Miyawaki A., Kato T.; RT "Identification of mitochondrial DNA polymorphisms that alter RT mitochondrial matrix pH and intracellular calcium dynamics."; RL (er) PLoS Genet. 2:e128, doi:10.1371/journal.pgen.0020128 (2006). RN [8] RP NUCLEOTIDE SEQUENCE. RC STRAIN=NDsq0117; RA Guo L., Oshida Y., Fuku N., Takeyasu T., Fujita Y., Kurata M., RA Sato Y., Ito M., Tanaka M.; RT "Mitochondrial genome polymorphisms associated with type-2 diabetes or RT obesity."; RL Mitochondrion 0:0-0(2004). CC -!- FUNCTION: Subunits I, II and III form the functional core of the CC enzyme complex (By similarity). CC -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 3 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AP008777; BAE14092.1; -; Genomic_DNA. DR EMBL; AP008916; BAE15899.1; -; Genomic_DNA. DR EMBL; AP009464; BAG39298.1; -; Genomic_DNA. DR SMR; Q4G6P4; 3-261. DR Ensembl; ENSG00000198938; Homo sapiens. DR HOVERGEN; Q4G6P4; -. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW. DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:InterPro. DR GO; GO:0006123; P:mitochondrial electron transport, cytochrom...; IEA:InterPro. DR InterPro; IPR000298; CytC_oxdse_III. DR InterPro; IPR013833; CytC_oxdse_III_a-bundle. DR Gene3D; G3DSA:1.20.120.80; CytC_oxdse_III_a-bundle; 1. DR PANTHER; PTHR11403; CytC_oxdse_III; 1. DR Pfam; PF00510; COX3; 1. DR ProDom; PD000382; CytC_oxdse_III; 1. DR PROSITE; PS50253; COX3; 1. PE 3: Inferred from homology; KW Mitochondrion; Transmembrane. SQ SEQUENCE 261 AA; 29924 MW; 0DA1A437A7A55B31 CRC64; MTHQSHAYHM VKPSPWPLTG ALSALLMTSG LAMWFHFHSM TLLMLGLLTS TLTMYQWWRD VTRESTYQGH HTPPVQKGLR YGMILFITSE VFFFAGFFWA FYHSSLAPTP QLGGHWPPTG ITPLNPLEVP LLNTSVLLAS GVSITWAHHS LMENNRNQMI QALLITILLG LYFTLLQASE YFESPFTISD GIYGSTFFVA TGFHGLHVII GSTFLTICFI RQLMFHFTSK HHFGFEAAAW YWHFVDVVWL FLYVSIYWWG S //