ID Q4G470_9CALI Unreviewed; 251 AA. AC Q4G470; DT 30-AUG-2005, integrated into UniProtKB/TrEMBL. DT 10-JUN-2008, sequence version 2. DT 05-JUN-2019, entry version 48. DE SubName: Full=RNA-dependent RNA polymerase {ECO:0000313|EMBL:AAT99643.2}; DE Flags: Fragment; OS Human calicivirus NLV/Hajmasker/487/2001/HUN. OC Viruses; Riboviria; Caliciviridae; Norovirus. OX NCBI_TaxID=289513 {ECO:0000313|EMBL:AAT99643.2}; RN [1] {ECO:0000313|EMBL:AAT99643.2} RP NUCLEOTIDE SEQUENCE. RC STRAIN=NLV/Hajmasker/487/2001/HUN {ECO:0000313|EMBL:AAT99643.2}; RX PubMed=15977235; DOI=10.1002/jmv.20403; RA Reuter G., Krisztalovics K., Vennema H., Koopmans M., Szucs G.; RT "Evidence of the etiological predominance of norovirus in RT gastroenteritis outbreaks--emerging new-variant and recombinant RT noroviruses in Hungary."; RL J. Med. Virol. 76:598-607(2005). RN [2] {ECO:0000313|EMBL:AAT99643.2} RP NUCLEOTIDE SEQUENCE. RC STRAIN=NLV/Hajmasker/487/2001/HUN {ECO:0000313|EMBL:AAT99643.2}; RX PubMed=16242995; DOI=10.1016/j.jcv.2005.07.012; RA Reuter G., Vennema H., Koopmans M., Szucs G.; RT "Epidemic spread of recombinant noroviruses with four capsid types in RT Hungary."; RL J. Clin. Virol. 35:84-88(2006). RN [3] {ECO:0000313|EMBL:AAT99643.2} RP NUCLEOTIDE SEQUENCE. RC STRAIN=NLV/Hajmasker/487/2001/HUN {ECO:0000313|EMBL:AAT99643.2}; RA Reuter G., Vennema H., Koopmans M., Szucs G.; RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:11128, Rhea:RHEA- CC COMP:11129, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, CC ChEBI:CHEBI:83400; EC=2.7.7.48; CC Evidence={ECO:0000256|SAAS:SAAS01134685}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY672563; AAT99643.2; -; Genomic_RNA. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0004386; F:helicase activity; IEA:InterPro. DR GO; GO:0003723; F:RNA binding; IEA:InterPro. DR GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-KW. DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro. DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro. DR InterPro; IPR004004; Helic/Pol/Pept_Calicivir-typ. DR InterPro; IPR001205; RNA-dir_pol_C. DR InterPro; IPR007094; RNA-dir_pol_PSvirus. DR Pfam; PF00680; RdRP_1; 1. DR PRINTS; PR00918; CALICVIRUSNS. DR PROSITE; PS50507; RDRP_SSRNA_POS; 1. PE 4: Predicted; KW Nucleotidyltransferase {ECO:0000256|SAAS:SAAS00124354}; KW RNA-directed RNA polymerase {ECO:0000256|SAAS:SAAS00124347, KW ECO:0000313|EMBL:AAT99643.2}; KW Transferase {ECO:0000256|SAAS:SAAS00482232}; KW Viral RNA replication {ECO:0000256|SAAS:SAAS00660848}. FT DOMAIN 1 98 RdRp catalytic. {ECO:0000259|PROSITE: FT PS50507}. FT NON_TER 1 1 {ECO:0000313|EMBL:AAT99643.2}. SQ SEQUENCE 251 AA; 28252 MW; 83045803E8310BD8 CRC64; EIMVKFSSEP HLAQVVAEDL LSPSVMDVGD FKISINEGLP SGVPCTSQWN SIAHWLLTLC ALSEVTDLSP DIIQANSLFS FYGDDEIVST DIKLDPEKLT TKLKEYGLKP TRPDKTEGPL IISEDLDGLT FLRRTVTRDP AGWFGKLDQS SILRQMYWTR GPNHEDPSET MIPHSQRPIQ LMSLLGEAAL HGPSFYSKIS KLVISELKEG GMDFYVPRQE PMFRWMRFSD LSTWEGDRNL APSFVNEDGV E //