ID   KCD21_HUMAN             Reviewed;         260 AA.
AC   Q4G0X4; B4DTR0;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2005, sequence version 1.
DT   07-JAN-2015, entry version 71.
DE   RecName: Full=BTB/POZ domain-containing protein KCTD21;
GN   Name=KCTD21;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SIMILARITY: Contains 1 BTB (POZ) domain. {ECO:0000255|PROSITE-
CC       ProRule:PRU00037}.
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DR   EMBL; AK300320; BAG62072.1; -; mRNA.
DR   EMBL; BC036058; AAH36058.1; -; mRNA.
DR   CCDS; CCDS31645.1; -.
DR   RefSeq; NP_001025030.1; NM_001029859.1.
DR   RefSeq; XP_005273985.1; XM_005273928.1.
DR   RefSeq; XP_005273986.1; XM_005273929.1.
DR   RefSeq; XP_006718580.1; XM_006718517.1.
DR   RefSeq; XP_006718581.1; XM_006718518.1.
DR   UniGene; Hs.528439; -.
DR   ProteinModelPortal; Q4G0X4; -.
DR   SMR; Q4G0X4; 1-106.
DR   BioGrid; 129500; 4.
DR   STRING; 9606.ENSP00000339340; -.
DR   DMDM; 121943921; -.
DR   MaxQB; Q4G0X4; -.
DR   PaxDb; Q4G0X4; -.
DR   PRIDE; Q4G0X4; -.
DR   Ensembl; ENST00000340067; ENSP00000339340; ENSG00000188997.
DR   GeneID; 283219; -.
DR   KEGG; hsa:283219; -.
DR   UCSC; uc001ozb.3; human.
DR   CTD; 283219; -.
DR   GeneCards; GC11M077882; -.
DR   HGNC; HGNC:27452; KCTD21.
DR   HPA; HPA041964; -.
DR   neXtProt; NX_Q4G0X4; -.
DR   PharmGKB; PA145148689; -.
DR   eggNOG; NOG244510; -.
DR   GeneTree; ENSGT00760000119013; -.
DR   HOGENOM; HOG000231837; -.
DR   HOVERGEN; HBG080457; -.
DR   InParanoid; Q4G0X4; -.
DR   OMA; YTRQNLK; -.
DR   OrthoDB; EOG741Z4M; -.
DR   PhylomeDB; Q4G0X4; -.
DR   TreeFam; TF315332; -.
DR   ChiTaRS; KCTD21; human.
DR   GenomeRNAi; 283219; -.
DR   NextBio; 93731; -.
DR   PRO; PR:Q4G0X4; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; Q4G0X4; -.
DR   CleanEx; HS_KCTD21; -.
DR   ExpressionAtlas; Q4G0X4; baseline and differential.
DR   Genevestigator; Q4G0X4; -.
DR   GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR   InterPro; IPR000210; BTB/POZ-like.
DR   InterPro; IPR011333; BTB/POZ_fold.
DR   InterPro; IPR003131; T1-type_BTB.
DR   Pfam; PF02214; BTB_2; 1.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Complete proteome; Reference proteome.
FT   CHAIN         1    260       BTB/POZ domain-containing protein KCTD21.
FT                                /FTId=PRO_0000281151.
FT   DOMAIN        3     72       BTB. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00037}.
FT   COILED       88    112       {ECO:0000255}.
FT   COMPBIAS    135    140       Poly-Ser.
FT   CONFLICT    152    152       S -> P (in Ref. 1; BAG62072).
FT                                {ECO:0000305}.
SQ   SEQUENCE   260 AA;  29643 MW;  E94BAD422C106070 CRC64;
     MSDPITLNVG GKLYTTSLAT LTSFPDSMLG AMFSGKMPTK RDSQGNCFID RDGKVFRYIL
     NFLRTSHLDL PEDFQEMGLL RREADFYQVQ PLIEALQEKE VELSKAEKNA MLNITLNQRV
     QTVHFTVREA PQIYSLSSSS MEVFNANIFS TSCLFLKLLG SKLFYCSNGN LSSITSHLQD
     PNHLTLDWVA NVEGLPEEEY TKQNLKRLWV VPANKQINSF QVFVEEVLKI ALSDGFCIDS
     SHPHALDFMN NKIIRLIRYR
//