ID HBG_ELEMA Reviewed; 147 AA. AC Q45XH7; DT 25-OCT-2005, integrated into UniProtKB/Swiss-Prot. DT 23-JAN-2007, sequence version 3. DT 02-OCT-2024, entry version 59. DE RecName: Full=Hemoglobin subunit gamma; DE AltName: Full=Gamma-globin; DE AltName: Full=Hemoglobin gamma chain; GN Name=HBG; OS Elephas maximus (Indian elephant). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Elephas. OX NCBI_TaxID=9783; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Sloan A.M., Campbell K.L.; RT "Atypical molecular evolution of afrotherian and xenarthran beta-globin RT cluster genes."; RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Gamma chains make up the fetal hemoglobin F, in combination CC with alpha chains. CC -!- SUBUNIT: Heterotetramer of two alpha chains and two gamma chains in CC fetal hemoglobin (Hb F). CC -!- TISSUE SPECIFICITY: Red blood cells. CC -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE- CC ProRule:PRU00238}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ091216; AAZ22687.1; -; Genomic_DNA. DR AlphaFoldDB; Q45XH7; -. DR SMR; Q45XH7; -. DR GO; GO:0072562; C:blood microparticle; IEA:TreeGrafter. DR GO; GO:0031838; C:haptoglobin-hemoglobin complex; IEA:TreeGrafter. DR GO; GO:0005833; C:hemoglobin complex; IEA:InterPro. DR GO; GO:0031720; F:haptoglobin binding; IEA:TreeGrafter. DR GO; GO:0020037; F:heme binding; IEA:InterPro. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0043177; F:organic acid binding; IEA:TreeGrafter. DR GO; GO:0019825; F:oxygen binding; IEA:InterPro. DR GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW. DR GO; GO:0004601; F:peroxidase activity; IEA:TreeGrafter. DR GO; GO:0042744; P:hydrogen peroxide catabolic process; IEA:TreeGrafter. DR CDD; cd08925; Hb-beta-like; 1. DR Gene3D; 1.10.490.10; Globins; 1. DR InterPro; IPR000971; Globin. DR InterPro; IPR009050; Globin-like_sf. DR InterPro; IPR012292; Globin/Proto. DR InterPro; IPR002337; Hemoglobin_b. DR InterPro; IPR050056; Hemoglobin_oxygen_transport. DR PANTHER; PTHR11442; HEMOGLOBIN FAMILY MEMBER; 1. DR PANTHER; PTHR11442:SF7; HEMOGLOBIN SUBUNIT EPSILON; 1. DR Pfam; PF00042; Globin; 1. DR PRINTS; PR00814; BETAHAEM. DR SUPFAM; SSF46458; Globin-like; 1. DR PROSITE; PS01033; GLOBIN; 1. PE 2: Evidence at transcript level; KW Heme; Iron; Metal-binding; Oxygen transport; Transport. FT CHAIN 1..147 FT /note="Hemoglobin subunit gamma" FT /id="PRO_0000053248" FT DOMAIN 3..147 FT /note="Globin" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00238" FT BINDING 64 FT /ligand="heme b" FT /ligand_id="ChEBI:CHEBI:60344" FT /ligand_part="Fe" FT /ligand_part_id="ChEBI:CHEBI:18248" FT /note="distal binding residue" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00238" FT BINDING 93 FT /ligand="heme b" FT /ligand_id="ChEBI:CHEBI:60344" FT /ligand_part="Fe" FT /ligand_part_id="ChEBI:CHEBI:18248" FT /note="proximal binding residue" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00238" SQ SEQUENCE 147 AA; 16230 MW; B3FB7BAF851EC018 CRC64; MVHFTAEEKA AITSLWGQVN VEETGGEALG RLLVVYPWTQ RFFDTFGNLS SASAIMGNPR VKAHGKKVLT SFGDAVKNLD NLKGTFAKLS ELHCDKLHVD PENFRLLGNV LVIVLANHFG KEFTPQVQAA WQKMVTGVAN ALAYKYH //