ID HBG_ELEMA Reviewed; 147 AA. AC Q45XH7; DT 25-OCT-2005, integrated into UniProtKB/Swiss-Prot. DT 23-JAN-2007, sequence version 3. DT 19-JAN-2010, entry version 23. DE RecName: Full=Hemoglobin subunit gamma; DE AltName: Full=Hemoglobin gamma chain; DE AltName: Full=Gamma-globin; GN Name=HBG; OS Elephas maximus (Indian elephant). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Elephas. OX NCBI_TaxID=9783; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Sloan A.M., Campbell K.L.; RT "Atypical molecular evolution of afrotherian and xenarthran beta- RT globin cluster genes."; RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Gamma chains make up the fetal hemoglobin F, in CC combination with alpha chains. CC -!- SUBUNIT: Heterotetramer of two alpha chains and two gamma chains CC in fetal hemoglobin (Hb F). CC -!- TISSUE SPECIFICITY: Red blood cells. CC -!- SIMILARITY: Belongs to the globin family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ091216; AAZ22687.1; -; Genomic_DNA. DR SMR; Q45XH7; 3-147. DR HOVERGEN; Q45XH7; -. DR GO; GO:0005833; C:hemoglobin complex; IEA:InterPro. DR GO; GO:0020037; F:heme binding; IEA:InterPro. DR GO; GO:0019825; F:oxygen binding; IEA:InterPro. DR GO; GO:0005344; F:oxygen transporter activity; IEA:UniProtKB-KW. DR GO; GO:0015671; P:oxygen transport; IEA:UniProtKB-KW. DR InterPro; IPR012292; Globin. DR InterPro; IPR009050; Globin-like. DR InterPro; IPR000971; Globin_subset. DR InterPro; IPR002337; Haemoglobin_b. DR Gene3D; G3DSA:1.10.490.10; Globin_related; 1. DR PANTHER; PTHR11442:SF7; Beta_haem; 1. DR Pfam; PF00042; Globin; 1. DR PRINTS; PR00814; BETAHAEM. DR PROSITE; PS01033; GLOBIN; 1. PE 2: Evidence at transcript level; KW Heme; Iron; Metal-binding; Oxygen transport; Transport. FT INIT_MET 1 1 Removed (By similarity). FT CHAIN 2 147 Hemoglobin subunit gamma. FT /FTId=PRO_0000053248. FT METAL 64 64 Iron (heme distal ligand) (By FT similarity). FT METAL 93 93 Iron (heme proximal ligand) (By FT similarity). SQ SEQUENCE 147 AA; 16230 MW; B3FB7BAF851EC018 CRC64; MVHFTAEEKA AITSLWGQVN VEETGGEALG RLLVVYPWTQ RFFDTFGNLS SASAIMGNPR VKAHGKKVLT SFGDAVKNLD NLKGTFAKLS ELHCDKLHVD PENFRLLGNV LVIVLANHFG KEFTPQVQAA WQKMVTGVAN ALAYKYH //