ID PRS44_MOUSE Reviewed; 372 AA. AC Q402U7; Q924U6; DT 19-OCT-2011, integrated into UniProtKB/Swiss-Prot. DT 27-SEP-2005, sequence version 1. DT 16-APR-2014, entry version 68. DE RecName: Full=Serine protease 44; DE EC=3.4.21.-; DE AltName: Full=Testis serine protease 4; DE Short=TESSP-4; DE AltName: Full=Testis-specific serine protease 4; DE Flags: Precursor; GN Name=Prss44; Synonyms=Tessp4; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RX PubMed=19798924; DOI=10.2108/zsj.26.294; RA Takano N., Kimura A., Takahashi T.; RT "Two distinct localization patterns of testis-specific serine protease RT 1 (TESSP1) in the seminiferous tubules of the mouse testis."; RL Zool. Sci. 26:294-300(2009). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). RA Matsui H., Takahashi T.; RT "Mus musculus mRNA for serine protease-like gene spliced variant-1."; RL Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein CC (Potential). CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q402U7-1; Sequence=Displayed; CC Name=2; CC IsoId=Q402U7-2; Sequence=VSP_041974, VSP_041975; CC -!- SIMILARITY: Belongs to the peptidase S1 family. CC -!- SIMILARITY: Contains 1 peptidase S1 domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB162857; BAE19954.1; -; mRNA. DR EMBL; AB047758; BAB63919.1; -; mRNA. DR EMBL; AC139378; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_683742.2; NM_148940.3. DR UniGene; Mm.200587; -. DR ProteinModelPortal; Q402U7; -. DR SMR; Q402U7; 112-345. DR MEROPS; S01.106; -. DR PRIDE; Q402U7; -. DR DNASU; 73336; -. DR Ensembl; ENSMUST00000098345; ENSMUSP00000095948; ENSMUSG00000032493. [Q402U7-1] DR GeneID; 73336; -. DR KEGG; mmu:73336; -. DR UCSC; uc009rut.2; mouse. [Q402U7-1] DR UCSC; uc009ruu.2; mouse. [Q402U7-2] DR CTD; 729756; -. DR MGI; MGI:1920586; Prss44. DR eggNOG; COG5640; -. DR GeneTree; ENSGT00750000117347; -. DR HOGENOM; HOG000251820; -. DR HOVERGEN; HBG013304; -. DR InParanoid; Q402U7; -. DR OMA; WIIKELS; -. DR OrthoDB; EOG75B84T; -. DR PhylomeDB; Q402U7; -. DR TreeFam; TF351676; -. DR NextBio; 338001; -. DR PRO; PR:Q402U7; -. DR ArrayExpress; Q402U7; -. DR Bgee; Q402U7; -. DR Genevestigator; Q402U7; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW. DR InterPro; IPR001254; Peptidase_S1. DR InterPro; IPR018114; Peptidase_S1_AS. DR InterPro; IPR001314; Peptidase_S1A. DR InterPro; IPR009003; Trypsin-like_Pept_dom. DR Pfam; PF00089; Trypsin; 1. DR PRINTS; PR00722; CHYMOTRYPSIN. DR SMART; SM00020; Tryp_SPc; 1. DR SUPFAM; SSF50494; SSF50494; 1. DR PROSITE; PS50240; TRYPSIN_DOM; 1. DR PROSITE; PS00134; TRYPSIN_HIS; 1. DR PROSITE; PS00135; TRYPSIN_SER; 1. PE 2: Evidence at transcript level; KW Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein; KW Hydrolase; Membrane; Protease; Reference proteome; Serine protease; KW Signal; Transmembrane; Transmembrane helix. FT SIGNAL 1 25 Potential. FT CHAIN 26 372 Serine protease 44. FT /FTId=PRO_0000413699. FT TOPO_DOM 26 351 Extracellular (Potential). FT TRANSMEM 352 372 Helical; (Potential). FT DOMAIN 112 345 Peptidase S1. FT ACT_SITE 152 152 Charge relay system (By similarity). FT ACT_SITE 197 197 Charge relay system (By similarity). FT ACT_SITE 297 297 Charge relay system (By similarity). FT CARBOHYD 208 208 N-linked (GlcNAc...) (Potential). FT DISULFID 137 153 By similarity. FT DISULFID 231 303 By similarity. FT DISULFID 262 283 By similarity. FT DISULFID 293 321 By similarity. FT VAR_SEQ 1 163 Missing (in isoform 2). FT /FTId=VSP_041974. FT VAR_SEQ 334 372 SYYRDWIIKELSRASCWKLSGFLVLSVCLVLHLAIVVAL FT -> ASPNDTALPPTHRAHCPQDCFQDPRLAKME (in FT isoform 2). FT /FTId=VSP_041975. SQ SEQUENCE 372 AA; 41073 MW; E15BB243F3B9784A CRC64; MAFQGCDCFG LLVWLLLLQT RLGKARMVPG TPSLSPLPSE NGLDDSGVNP QERPLTGMPE TSLPRKPGDS TRPLDSMAFT PGQSFSTMSL SRQPFPTWVP PTSACGHRTA RIVGGRPAPA RKWPWQVSLQ VHKQHICGGS LISKWWVITA AHCVYGHLDY AVFMGDADLW SKRPVRIPVQ DIIVHQDFSM MRTVVHDIAL VLLAFPVNYS VNIQPVCIPE KSFLVQPGTL CWVTGWGKVL EQGRSSRILQ EIELNIIRHE KCNQILKDIM GNIFTLVQEG GVCGYNEKGG DACQGDSGGP LVCEFNKTWV QVGIVSWGLG CGRIGYPGVY TEVSYYRDWI IKELSRASCW KLSGFLVLSV CLVLHLAIVV AL //