ID Q3ZCD3_BOVIN Unreviewed; 124 AA. AC Q3ZCD3; DT 27-SEP-2005, integrated into UniProtKB/TrEMBL. DT 27-SEP-2005, sequence version 1. DT 24-JUL-2024, entry version 125. DE RecName: Full=Tax1-binding protein 3 {ECO:0000256|PIRNR:PIRNR037712}; GN Name=TAX1BP3 {ECO:0000313|EMBL:AAI02511.1, GN ECO:0000313|Ensembl:ENSBTAP00000001098.2, GN ECO:0000313|VGNC:VGNC:35620}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; OC Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|EMBL:AAI02511.1}; RN [1] {ECO:0000313|EMBL:AAI02511.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Crossbred x Angus {ECO:0000313|EMBL:AAI02511.1}; RC TISSUE=Ileum {ECO:0000313|EMBL:AAI02511.1}; RA Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y., RA Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C., RA Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J., RA Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J., RA Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D., Siddiqui A., RA Holt R., Jones S.J., Marra M.A.; RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSBTAP00000001098.2, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000001098.2, RC ECO:0000313|Proteomes:UP000009136}; RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A., RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C., RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.; RT "ARS-UCD1.2."; RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSBTAP00000001098.2} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000001098.2}; RG Ensembl; RL Submitted (APR-2024) to UniProtKB. CC -!- FUNCTION: May regulate a number of protein-protein interactions by CC competing for PDZ domain binding sites. CC {ECO:0000256|PIRNR:PIRNR037712}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR037712}. CC Nucleus {ECO:0000256|PIRNR:PIRNR037712}. Cell membrane CC {ECO:0000256|PIRNR:PIRNR037712}; Peripheral membrane protein CC {ECO:0000256|PIRNR:PIRNR037712}; Cytoplasmic side CC {ECO:0000256|PIRNR:PIRNR037712}. Note=Recruited to the cell membrane by CC interaction with membrane proteins. {ECO:0000256|PIRNR:PIRNR037712}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC102510; AAI02511.1; -; mRNA. DR RefSeq; NP_001029646.1; NM_001034474.1. DR STRING; 9913.ENSBTAP00000001098; -. DR PaxDb; 9913-ENSBTAP00000001098; -. DR Ensembl; ENSBTAT00000001098.3; ENSBTAP00000001098.2; ENSBTAG00000000833.4. DR GeneID; 514852; -. DR KEGG; bta:514852; -. DR CTD; 30851; -. DR VEuPathDB; HostDB:ENSBTAG00000000833; -. DR VGNC; VGNC:35620; TAX1BP3. DR eggNOG; KOG3553; Eukaryota. DR GeneTree; ENSGT00390000002877; -. DR HOGENOM; CLU_130477_0_0_1; -. DR OMA; HKETEIN; -. DR OrthoDB; 5343673at2759; -. DR TreeFam; TF318964; -. DR Reactome; R-BTA-5666185; RHO GTPases Activate Rhotekin and Rhophilins. DR ChiTaRS; TAX1BP3; cattle. DR Proteomes; UP000009136; Chromosome 19. DR Bgee; ENSBTAG00000000833; Expressed in parenchyma of mammary gland and 107 other cell types or tissues. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:2000009; P:negative regulation of protein localization to cell surface; IBA:GO_Central. DR GO; GO:0007266; P:Rho protein signal transduction; IBA:GO_Central. DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-UniRule. DR CDD; cd00992; PDZ_signaling; 1. DR Gene3D; 2.30.42.10; -; 1. DR InterPro; IPR001478; PDZ. DR InterPro; IPR036034; PDZ_sf. DR InterPro; IPR050614; Synaptic_Scaffolding_LAP-MAGUK. DR InterPro; IPR017268; Tax1-binding_p3. DR PANTHER; PTHR23119; DISCS LARGE; 1. DR PANTHER; PTHR23119:SF51; DISKS LARGE 1 TUMOR SUPPRESSOR PROTEIN; 1. DR Pfam; PF00595; PDZ; 1. DR PIRSF; PIRSF037712; Tax1-binding_p3; 1. DR SMART; SM00228; PDZ; 1. DR SUPFAM; SSF50156; PDZ domain-like; 1. DR PROSITE; PS50106; PDZ; 1. PE 1: Evidence at protein level; KW Cytoplasm {ECO:0000256|PIRNR:PIRNR037712}; KW Membrane {ECO:0000256|PIRNR:PIRNR037712}; KW Nucleus {ECO:0000256|PIRNR:PIRNR037712}; KW Proteomics identification {ECO:0007829|PeptideAtlas:Q3ZCD3}; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}; KW Wnt signaling pathway {ECO:0000256|PIRNR:PIRNR037712}. FT DOMAIN 15..112 FT /note="PDZ" FT /evidence="ECO:0000259|PROSITE:PS50106" SQ SEQUENCE 124 AA; 13721 MW; F29BD2F475F69DCD CRC64; MSYVPGQPVT AVVQRVEIHK LRQGENLILG FSIGGGIDQD PSQNPFSEDK TDKGIYVTRV SEGGPAEIAG LQIGDKIMQV NGWDMTMVTH DQARKRLTKR SEEVVRLLVT RQSLQKAVQQ SMLS //