ID Q3ZCD3_BOVIN Unreviewed; 124 AA. AC Q3ZCD3; DT 27-SEP-2005, integrated into UniProtKB/TrEMBL. DT 27-SEP-2005, sequence version 1. DT 13-NOV-2019, entry version 101. DE RecName: Full=Tax1-binding protein 3 {ECO:0000256|PIRNR:PIRNR037712}; GN Name=TAX1BP3 {ECO:0000313|EMBL:AAI02511.1, GN ECO:0000313|Ensembl:ENSBTAP00000001098, ECO:0000313|VGNC:VGNC:35620}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|EMBL:AAI02511.1}; RN [1] {ECO:0000313|EMBL:AAI02511.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Crossbred x Angus {ECO:0000313|EMBL:AAI02511.1}; RC TISSUE=Ileum {ECO:0000313|EMBL:AAI02511.1}; RA Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y., RA Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C., RA Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J., RA Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J., RA Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D., RA Siddiqui A., Holt R., Jones S.J., Marra M.A.; RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSBTAP00000001098} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000001098}; RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. RN [3] {ECO:0000313|Ensembl:ENSBTAP00000001098, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000001098, RC ECO:0000313|Proteomes:UP000009136}; RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A., RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C., RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., RA Medrano J.F.; RT "ARS-UCD1.2."; RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: May regulate a number of protein-protein interactions by CC competing for PDZ domain binding sites. CC {ECO:0000256|PIRNR:PIRNR037712}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR037712}. CC Nucleus {ECO:0000256|PIRNR:PIRNR037712}. Cell membrane CC {ECO:0000256|PIRNR:PIRNR037712}; Peripheral membrane protein CC {ECO:0000256|PIRNR:PIRNR037712}; Cytoplasmic side CC {ECO:0000256|PIRNR:PIRNR037712}. Note=Recruited to the cell CC membrane by interaction with membrane proteins. CC {ECO:0000256|PIRNR:PIRNR037712}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC102510; AAI02511.1; -; mRNA. DR RefSeq; NP_001029646.1; NM_001034474.1. DR STRING; 9913.ENSBTAP00000001098; -. DR Ensembl; ENSBTAT00000001098; ENSBTAP00000001098; ENSBTAG00000000833. DR GeneID; 514852; -. DR KEGG; bta:514852; -. DR CTD; 30851; -. DR VGNC; VGNC:35620; TAX1BP3. DR eggNOG; KOG3553; Eukaryota. DR eggNOG; ENOG4111IK0; LUCA. DR GeneTree; ENSGT00390000002877; -. DR HOGENOM; HOG000015753; -. DR OMA; IYVTRIT; -. DR OrthoDB; 1471323at2759; -. DR TreeFam; TF318964; -. DR Reactome; R-BTA-5666185; RHO GTPases Activate Rhotekin and Rhophilins. DR ChiTaRS; TAX1BP3; cattle. DR Proteomes; UP000009136; Chromosome 19. DR Bgee; ENSBTAG00000000833; Expressed in 9 organ(s), highest expression level in heart. DR GO; GO:0015629; C:actin cytoskeleton; IEA:Ensembl. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0001650; C:fibrillar center; IEA:Ensembl. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0008013; F:beta-catenin binding; IEA:Ensembl. DR GO; GO:0008022; F:protein C-terminus binding; IEA:Ensembl. DR GO; GO:0090630; P:activation of GTPase activity; IBA:GO_Central. DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl. DR GO; GO:2000009; P:negative regulation of protein localization to cell surface; IBA:GO_Central. DR GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IEA:Ensembl. DR GO; GO:0007266; P:Rho protein signal transduction; IBA:GO_Central. DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-UniRule. DR InterPro; IPR001478; PDZ. DR InterPro; IPR036034; PDZ_sf. DR InterPro; IPR017268; Tax1-binding_p3. DR Pfam; PF00595; PDZ; 1. DR PIRSF; PIRSF037712; Tax1-binding_p3; 1. DR SMART; SM00228; PDZ; 1. DR SUPFAM; SSF50156; SSF50156; 1. DR PROSITE; PS50106; PDZ; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000009136}; KW Cytoplasm {ECO:0000256|PIRNR:PIRNR037712}; KW Membrane {ECO:0000256|PIRNR:PIRNR037712}; KW Nucleus {ECO:0000256|PIRNR:PIRNR037712}; KW Proteomics identification {ECO:0000213|PeptideAtlas:Q3ZCD3}; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}; KW Wnt signaling pathway {ECO:0000256|PIRNR:PIRNR037712}. FT DOMAIN 15 112 PDZ. {ECO:0000259|PROSITE:PS50106}. SQ SEQUENCE 124 AA; 13721 MW; F29BD2F475F69DCD CRC64; MSYVPGQPVT AVVQRVEIHK LRQGENLILG FSIGGGIDQD PSQNPFSEDK TDKGIYVTRV SEGGPAEIAG LQIGDKIMQV NGWDMTMVTH DQARKRLTKR SEEVVRLLVT RQSLQKAVQQ SMLS //