ID Q3ZB92_DANRE Unreviewed; 351 AA. AC Q3ZB92; DT 27-SEP-2005, integrated into UniProtKB/TrEMBL. DT 27-SEP-2005, sequence version 1. DT 18-JUL-2018, entry version 125. DE SubName: Full=Protein kinase, cAMP-dependent, catalytic, beta {ECO:0000313|EMBL:AAI03488.1}; DE SubName: Full=Protein kinase, cAMP-dependent, catalytic, beta b {ECO:0000313|Ensembl:ENSDARP00000076580}; GN Name=prkacbb {ECO:0000313|Ensembl:ENSDARP00000076580, GN ECO:0000313|ZFIN:ZDB-GENE-050904-4}; GN Synonyms=prkacb {ECO:0000313|EMBL:AAI03488.1}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI03488.1}; RN [1] {ECO:0000313|EMBL:AAI03488.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=Singapore local strain {ECO:0000313|EMBL:AAI03488.1}; RC TISSUE=Embryo {ECO:0000313|EMBL:AAI03488.1}; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSDARP00000076580} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000076580}; RG Ensembl; RL Submitted (NOV-2012) to UniProtKB. RN [3] {ECO:0000313|Ensembl:ENSDARP00000076580, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000076580, RC ECO:0000313|Proteomes:UP000000437}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T., RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., RA Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the RT human genome."; RL Nature 496:498-503(2013). CC -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. CC {ECO:0000256|SAAS:SAAS00935732}. CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CC {ECO:0000256|RuleBase:RU000304}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CR848026; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; FP015789; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC103487; AAI03488.1; -; mRNA. DR RefSeq; NP_001030148.1; NM_001034976.1. DR RefSeq; XP_017206779.1; XM_017351290.1. DR UniGene; Dr.21332; -. DR STRING; 7955.ENSDARP00000105368; -. DR Ensembl; ENSDART00000082143; ENSDARP00000076580; ENSDARG00000059125. DR GeneID; 563147; -. DR KEGG; dre:563147; -. DR CTD; 563147; -. DR ZFIN; ZDB-GENE-050904-4; prkacbb. DR eggNOG; KOG0616; Eukaryota. DR eggNOG; ENOG410XPQQ; LUCA. DR GeneTree; ENSGT00810000125385; -. DR HOGENOM; HOG000233033; -. DR HOVERGEN; HBG108317; -. DR KO; K04345; -. DR OMA; GKEFCEF; -. DR OrthoDB; EOG091G10O8; -. DR TreeFam; TF313399; -. DR Proteomes; UP000000437; Chromosome 2. DR Bgee; ENSDARG00000059125; -. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. DR InterPro; IPR000961; AGC-kinase_C. DR InterPro; IPR011009; Kinase-like_dom_sf. DR InterPro; IPR000719; Prot_kinase_dom. DR InterPro; IPR017441; Protein_kinase_ATP_BS. DR InterPro; IPR008271; Ser/Thr_kinase_AS. DR Pfam; PF00069; Pkinase; 1. DR SMART; SM00133; S_TK_X; 1. DR SMART; SM00220; S_TKc; 1. DR SUPFAM; SSF56112; SSF56112; 1. DR PROSITE; PS51285; AGC_KINASE_CTER; 1. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1. PE 1: Evidence at protein level; KW ATP-binding {ECO:0000256|RuleBase:RU000304, KW ECO:0000256|SAAS:SAAS00593399}; KW Complete proteome {ECO:0000313|Proteomes:UP000000437}; KW Kinase {ECO:0000256|SAAS:SAAS00593820, ECO:0000313|EMBL:AAI03488.1}; KW Nucleotide-binding {ECO:0000256|RuleBase:RU000304, KW ECO:0000256|SAAS:SAAS00593601}; KW Proteomics identification {ECO:0000213|PeptideAtlas:Q3ZB92}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Serine/threonine-protein kinase {ECO:0000256|RuleBase:RU000304, KW ECO:0000256|SAAS:SAAS00593706}; KW Transferase {ECO:0000256|SAAS:SAAS00592725}. FT DOMAIN 44 298 Protein kinase. {ECO:0000259|PROSITE: FT PS50011}. FT DOMAIN 299 351 AGC-kinase C-terminal. FT {ECO:0000259|PROSITE:PS51285}. SQ SEQUENCE 351 AA; 40650 MW; 969567145CA2C677 CRC64; MGNAATAKKG NELESVKEFL AKAKEDFLRK WESPQQSTTC LDDFDRQKTL GTGSFGRVLL VKHKASDQYY AMKVLDKQKV VKLKQVEHTL NEKRILQAVS FPFLVRLEYA FKDNSNLYMV MEYVPGGEMF SHLRRIGRFS EPHARFYAAQ IVLTFEYLHS LDLIYRDLKP ENLLIDQHGY IQVTDFGFAK RVKGRTWTLC GTPEYLAPEI ILSKGYNKAV DWWALGVLIY EMAAGYPPFF ADQPIQIYEK IVSGKVRFPS HFSSDLKDLL RNLLQVDLTK RFGNLRNGVN DIKNHKWFAT TDWIAIYERK VEAPFIPKCR GPGDTSNFDD YEEEDIRVSV TEKCAKEFSE F //