ID Q3ZAS0_MOUSE Unreviewed; 814 AA. AC Q3ZAS0; DT 27-SEP-2005, integrated into UniProtKB/TrEMBL. DT 27-SEP-2005, sequence version 1. DT 03-OCT-2012, entry version 64. DE RecName: Full=Sodium/hydrogen exchanger; GN Name=Slc9a2; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=PCR rescued clones; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., RA Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [3] RP IDENTIFICATION. RC STRAIN=C57BL/6J; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 CC (CPA1) transporter (TC 2.A.36) family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC154392; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC103685; AAI03686.1; -; mRNA. DR EMBL; BC104737; AAI04738.1; -; mRNA. DR IPI; IPI00340247; -. DR RefSeq; NP_001028461.2; NM_001033289.2. DR UniGene; Mm.256414; -. DR SMR; Q3ZAS0; 136-161, 231-256, 319-346, 484-526, 592-655. DR STRING; Q3ZAS0; -. DR Ensembl; ENSMUST00000027231; ENSMUSP00000027231; ENSMUSG00000026062. DR GeneID; 226999; -. DR KEGG; mmu:226999; -. DR UCSC; uc007aun.1; mouse. DR CTD; 6549; -. DR MGI; MGI:105075; Slc9a2. DR GeneTree; ENSGT00560000077158; -. DR HOGENOM; HOG000247044; -. DR HOVERGEN; HBG052615; -. DR InParanoid; Q3ZAS0; -. DR KO; K14722; -. DR OMA; FTHNIRV; -. DR NextBio; 378434; -. DR ArrayExpress; Q3ZAS0; -. DR Genevestigator; Q3ZAS0; -. DR GO; GO:0005903; C:brush border; TAS:MGI. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0015385; F:sodium:hydrogen antiporter activity; IDA:MGI. DR GO; GO:0008104; P:protein localization; IMP:MGI. DR GO; GO:0006885; P:regulation of pH; IDA:MGI. DR InterPro; IPR006153; Cation/H_exchanger. DR InterPro; IPR018422; Cation/H_exchanger_CPA1. DR InterPro; IPR001953; Na/H_exchanger_2. DR InterPro; IPR004709; NaH_exchanger. DR PANTHER; PTHR10110; PTHR10110; 1. DR Pfam; PF00999; Na_H_Exchanger; 1. DR PRINTS; PR01084; NAHEXCHNGR. DR PRINTS; PR01086; NAHEXCHNGR2. DR TIGRFAMs; TIGR00840; b_cpa1; 1. PE 2: Evidence at transcript level; KW Antiport; Complete proteome; Ion transport; Membrane; KW Reference proteome; Sodium; Sodium transport; Transmembrane; KW Transmembrane helix; Transport. SQ SEQUENCE 814 AA; 91646 MW; 8543A204ED2528C2 CRC64; MGPRGTAHSV RAPLSWLLLL LLSLQVAVPA GALAETLLDA PRARGASSNP PSPASVVAPG TTPFEESRLP VFTLDYPHVQ IPFEITLWIL LASLAKIGFH LYHKLPTIVP ESCLLIMVGL LLGGIIFGVD EKSPPAMKTD VFFLYLLPPI VLDAGYFMPT RPFFENFGTI FWYAVVGTLW NSIGIGVSLF GICQIEAFGL SDITLLQNLL FGSLISAVDP VAVLAVFENI HVNEQLYILV FGESLLNDAV TVVLYNLFKS FCQMKTIQTV DVFAGIANFF VVGIGGVLIG ILLGFIAAFT TRFTHNIRVI EPLFVFLYSY LSYITAEMFH LSGIMAITAC AMTMNKYVEE NVSQKSYTTI KYFMKMLSSV SETLIFIFMG VSTVGKNHEW NWAFVCFTLA FCLIWRALGV FVLTQVINWF RTIPLTFKDQ FIIAYGGLRG AICFALVFLL PATVFPRKKL FITAAIVVIF FTVFILGITI RPLVEFLDVK RSNKKQQAVS EEIHCRFFDH VKTGIEDVCG HWGHNFWRDK FKKFDDKYLR KLLIRENQPK SSIVSLYKKL EIKHAIEMAE TGMISTVPSF ASLNDCREEK IRKLTPGEMD EIREILSRNL YQIRQRTLSY NRHNLTADTS ERQAKEILIR RRHSLRESLR KDNSSNRERR ASTSTSRYLS LPKNTKLPEK LQKKKKVSNA DGNSSDSDPD VGTTVLNLQP RTRRFLPDQF SKKASQAYKM EWKNEVDVGS VRVPPSVSPA PRSKDGGTQT PGLLRQPLLS KDQRFGRGRE DSLTEDVPPK PPPRLVRRAS EPGNRKGRLG NEKP //