ID Q3ZAS0_MOUSE Unreviewed; 814 AA. AC Q3ZAS0; DT 27-SEP-2005, integrated into UniProtKB/TrEMBL. DT 27-SEP-2005, sequence version 1. DT 18-JUL-2018, entry version 122. DE RecName: Full=Sodium/hydrogen exchanger {ECO:0000256|RuleBase:RU003722}; GN Name=Slc9a2 {ECO:0000313|EMBL:AAI03686.1, GN ECO:0000313|Ensembl:ENSMUSP00000027231, ECO:0000313|MGI:MGI:105075}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAI03686.1}; RN [1] {ECO:0000313|EMBL:AAI03686.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=PCR rescued clones {ECO:0000313|EMBL:AAI03686.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., RA Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000027231, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000027231, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [3] {ECO:0000213|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and RT expression."; RL Cell 143:1174-1189(2010). RN [4] {ECO:0000313|Ensembl:ENSMUSP00000027231} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000027231}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 CC (CPA1) transporter (TC 2.A.36) family. CC {ECO:0000256|RuleBase:RU003722}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC154392; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC103685; AAI03686.1; -; mRNA. DR EMBL; BC104737; AAI04738.1; -; mRNA. DR RefSeq; NP_001028461.2; NM_001033289.2. DR UniGene; Mm.256414; -. DR STRING; 10090.ENSMUSP00000027231; -. DR Ensembl; ENSMUST00000027231; ENSMUSP00000027231; ENSMUSG00000026062. DR GeneID; 226999; -. DR KEGG; mmu:226999; -. DR UCSC; uc007aun.1; mouse. DR CTD; 6549; -. DR MGI; MGI:105075; Slc9a2. DR eggNOG; KOG1966; Eukaryota. DR eggNOG; COG0025; LUCA. DR GeneTree; ENSGT00760000119074; -. DR HOGENOM; HOG000247044; -. DR HOVERGEN; HBG052615; -. DR KO; K14722; -. DR OMA; AYKMEWK; -. DR OrthoDB; EOG091G02Q0; -. DR TreeFam; TF317212; -. DR Reactome; R-MMU-425986; Sodium/Proton exchangers. DR Proteomes; UP000000589; Chromosome 1. DR Bgee; ENSMUSG00000026062; -. DR GO; GO:0005903; C:brush border; TAS:MGI. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0015386; F:potassium:proton antiporter activity; IBA:GO_Central. DR GO; GO:0015385; F:sodium:proton antiporter activity; IDA:MGI. DR GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central. DR GO; GO:0008104; P:protein localization; IMP:MGI. DR GO; GO:0051453; P:regulation of intracellular pH; IBA:GO_Central. DR GO; GO:0006885; P:regulation of pH; IDA:MGI. DR GO; GO:0098719; P:sodium ion import across plasma membrane; IBA:GO_Central. DR GO; GO:0006814; P:sodium ion transport; IDA:MGI. DR InterPro; IPR006153; Cation/H_exchanger. DR InterPro; IPR018422; Cation/H_exchanger_CPA1. DR InterPro; IPR001953; Na/H_exchanger_2. DR InterPro; IPR004709; NaH_exchanger. DR InterPro; IPR032103; NHE_CaM-bd. DR PANTHER; PTHR10110; PTHR10110; 1. DR Pfam; PF00999; Na_H_Exchanger; 1. DR Pfam; PF16644; NEXCaM_BD; 1. DR PRINTS; PR01084; NAHEXCHNGR. DR PRINTS; PR01086; NAHEXCHNGR2. DR TIGRFAMs; TIGR00840; b_cpa1; 1. PE 1: Evidence at protein level; KW Antiport {ECO:0000256|RuleBase:RU003722, KW ECO:0000256|SAAS:SAAS00029193}; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Ion transport {ECO:0000256|RuleBase:RU003722}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}; KW Sodium {ECO:0000256|RuleBase:RU003722}; KW Sodium transport {ECO:0000256|RuleBase:RU003722}; KW Transmembrane {ECO:0000256|RuleBase:RU003722, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}; KW Transport {ECO:0000256|RuleBase:RU003722}. FT SIGNAL 1 34 {ECO:0000256|SAM:SignalP}. FT CHAIN 35 814 Sodium/hydrogen exchanger. FT {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015297650. FT TRANSMEM 108 129 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 141 158 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 170 193 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 205 230 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 236 258 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 270 300 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 320 341 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 390 420 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 432 454 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 460 484 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 85 485 Na_H_Exchanger. {ECO:0000259|Pfam: FT PF00999}. FT DOMAIN 577 685 NEXCaM_BD. {ECO:0000259|Pfam:PF16644}. SQ SEQUENCE 814 AA; 91646 MW; 8543A204ED2528C2 CRC64; MGPRGTAHSV RAPLSWLLLL LLSLQVAVPA GALAETLLDA PRARGASSNP PSPASVVAPG TTPFEESRLP VFTLDYPHVQ IPFEITLWIL LASLAKIGFH LYHKLPTIVP ESCLLIMVGL LLGGIIFGVD EKSPPAMKTD VFFLYLLPPI VLDAGYFMPT RPFFENFGTI FWYAVVGTLW NSIGIGVSLF GICQIEAFGL SDITLLQNLL FGSLISAVDP VAVLAVFENI HVNEQLYILV FGESLLNDAV TVVLYNLFKS FCQMKTIQTV DVFAGIANFF VVGIGGVLIG ILLGFIAAFT TRFTHNIRVI EPLFVFLYSY LSYITAEMFH LSGIMAITAC AMTMNKYVEE NVSQKSYTTI KYFMKMLSSV SETLIFIFMG VSTVGKNHEW NWAFVCFTLA FCLIWRALGV FVLTQVINWF RTIPLTFKDQ FIIAYGGLRG AICFALVFLL PATVFPRKKL FITAAIVVIF FTVFILGITI RPLVEFLDVK RSNKKQQAVS EEIHCRFFDH VKTGIEDVCG HWGHNFWRDK FKKFDDKYLR KLLIRENQPK SSIVSLYKKL EIKHAIEMAE TGMISTVPSF ASLNDCREEK IRKLTPGEMD EIREILSRNL YQIRQRTLSY NRHNLTADTS ERQAKEILIR RRHSLRESLR KDNSSNRERR ASTSTSRYLS LPKNTKLPEK LQKKKKVSNA DGNSSDSDPD VGTTVLNLQP RTRRFLPDQF SKKASQAYKM EWKNEVDVGS VRVPPSVSPA PRSKDGGTQT PGLLRQPLLS KDQRFGRGRE DSLTEDVPPK PPPRLVRRAS EPGNRKGRLG NEKP //