ID Q3V159_MOUSE Unreviewed; 474 AA. AC Q3V159; DT 11-OCT-2005, integrated into UniProtKB/TrEMBL. DT 11-OCT-2005, sequence version 1. DT 24-JAN-2024, entry version 124. DE RecName: Full=Lamin-B2 {ECO:0008006|Google:ProtNLM}; GN Name=Lmnb2 {ECO:0000313|MGI:MGI:96796}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAE21293.1}; RN [1] {ECO:0000313|EMBL:BAE21293.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE21293.1}; RC TISSUE=Testis {ECO:0000313|EMBL:BAE21293.1}; RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9; RA Carninci P., Hayashizaki Y.; RT "High-efficiency full-length cDNA cloning."; RL Methods Enzymol. 303:19-44(1999). RN [2] {ECO:0000313|EMBL:BAE21293.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE21293.1}; RC TISSUE=Testis {ECO:0000313|EMBL:BAE21293.1}; RX PubMed=11042159; DOI=10.1101/gr.145100; RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.; RT "Normalization and subtraction of cap-trapper-selected cDNAs to prepare RT full-length cDNA libraries for rapid discovery of new genes."; RL Genome Res. 10:1617-1630(2000). RN [3] {ECO:0000313|EMBL:BAE21293.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE21293.1}; RC TISSUE=Testis {ECO:0000313|EMBL:BAE21293.1}; RX PubMed=11076861; DOI=10.1101/gr.152600; RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., RA Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R., RA Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., RA Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., RA Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., RA Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.; RT "RIKEN integrated sequence analysis (RISA) system--384-format sequencing RT pipeline with 384 multicapillary sequencer."; RL Genome Res. 10:1757-1771(2000). RN [4] {ECO:0000313|EMBL:BAE21293.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE21293.1}; RC TISSUE=Testis {ECO:0000313|EMBL:BAE21293.1}; RX PubMed=11217851; DOI=10.1038/35055500; RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium; RT "Functional annotation of a full-length mouse cDNA collection."; RL Nature 409:685-690(2001). RN [5] {ECO:0000313|EMBL:BAE21293.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE21293.1}; RC TISSUE=Testis {ECO:0000313|EMBL:BAE21293.1}; RX PubMed=12466851; DOI=10.1038/nature01266; RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). RN [6] {ECO:0000313|EMBL:BAE21293.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE21293.1}; RC TISSUE=Testis {ECO:0000313|EMBL:BAE21293.1}; RA Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., RA Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., RA Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H., Nomura K., RA Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., RA Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.; RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:BAE21293.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE21293.1}; RC TISSUE=Testis {ECO:0000313|EMBL:BAE21293.1}; RG The FANTOM Consortium; RG Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group); RT "The Transcriptional Landscape of the Mammalian Genome."; RL Science 309:1559-1563(2005). RN [8] {ECO:0000313|EMBL:BAE21293.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE21293.1}; RC TISSUE=Testis {ECO:0000313|EMBL:BAE21293.1}; RX PubMed=16141073; DOI=10.1126/science.1112009; RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium; RT "Antisense Transcription in the Mammalian Transcriptome."; RL Science 309:1564-1566(2005). CC -!- SUBCELLULAR LOCATION: Nucleus lamina {ECO:0000256|ARBA:ARBA00024186}. CC -!- SIMILARITY: Belongs to the intermediate filament family. CC {ECO:0000256|RuleBase:RU000685}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK132671; BAE21293.1; -; mRNA. DR RefSeq; NP_001334069.1; NM_001347140.1. DR AlphaFoldDB; Q3V159; -. DR SMR; Q3V159; -. DR MaxQB; Q3V159; -. DR Antibodypedia; 10783; 416 antibodies from 37 providers. DR DNASU; 16907; -. DR GeneID; 16907; -. DR UCSC; uc007gfj.1; mouse. DR AGR; MGI:96796; -. DR CTD; 84823; -. DR MGI; MGI:96796; Lmnb2. DR VEuPathDB; HostDB:ENSMUSG00000062075; -. DR HOGENOM; CLU_012560_9_0_1; -. DR OrthoDB; 72418at2759; -. DR BioGRID-ORCS; 16907; 1 hit in 78 CRISPR screens. DR ChiTaRS; Lmnb2; mouse. DR ExpressionAtlas; Q3V159; baseline and differential. DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW. DR GO; GO:0005635; C:nuclear envelope; IEA:UniProt. DR GO; GO:0005652; C:nuclear lamina; IEA:UniProtKB-SubCell. DR Gene3D; 1.20.5.170; -; 1. DR Gene3D; 2.60.40.1260; Lamin Tail domain; 1. DR InterPro; IPR018039; IF_conserved. DR InterPro; IPR039008; IF_rod_dom. DR InterPro; IPR001322; Lamin_tail_dom. DR InterPro; IPR036415; Lamin_tail_dom_sf. DR PANTHER; PTHR45721; LAMIN DM0-RELATED; 1. DR PANTHER; PTHR45721:SF2; LAMIN-B2; 1. DR Pfam; PF00038; Filament; 1. DR Pfam; PF00932; LTD; 1. DR SMART; SM01391; Filament; 1. DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 1. DR SUPFAM; SSF74853; Lamin A/C globular tail domain; 1. DR PROSITE; PS00226; IF_ROD_1; 1. DR PROSITE; PS51842; IF_ROD_2; 1. DR PROSITE; PS51841; LTD; 1. PE 2: Evidence at transcript level; KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils}; KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754, KW ECO:0000256|RuleBase:RU000685}; KW Lipoprotein {ECO:0000256|ARBA:ARBA00023289}; KW Prenylation {ECO:0000256|ARBA:ARBA00023289}. FT DOMAIN 1..258 FT /note="IF rod" FT /evidence="ECO:0000259|PROSITE:PS51842" FT DOMAIN 316..437 FT /note="LTD" FT /evidence="ECO:0000259|PROSITE:PS51841" FT REGION 1..20 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 40..69 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 255..318 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 430..474 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 156..233 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 40..57 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 262..286 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 303..318 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 474 AA; 53268 MW; 9303CBEC3C77DE75 CRC64; MGESESMRGT GEGCGRDCPE AARPLMETVE GALPELRGRP LREYVKRRPR GLGKTPVEDP VKSEGAVGYP RTWNNHLRVP TREQEVRETR RRHERRLVEV DSSRQQEYDF KMAQALEDLR SQHDEQVRLY RVELEQTYQA KLDNAKLLSD QNDKAAHAAR EELKEARMRV ESLSYQLLGL QKQASAAENH IHELEEALAG ERDKFRKMLD AKEQEMTEVR DAMQQQLAEY QELLDIKLAL DMEISAYRKL LEGEEERLKL SPSPSSRITI SRATSSSSSS SGVGMSVGQG RGKRRRLETE DTSGSPSRAS RVSSGSRLAQ QTVATGVVNI DEVDPEGRFV RLKNSSDKDQ SLGNWRIKRQ VLEGEDIAYK FTPKYVLRAG QTVTVWAAGA GATHSPPSTL VWKSQTNWGP GESFRTALVS ADGEEVAVKA AKHSSVQGRE NGEEEEEEEA EFGEEDLFHQ QGDPRTTSRG CRLM //