ID Q3UTZ0_MOUSE Unreviewed; 386 AA. AC Q3UTZ0; DT 11-OCT-2005, integrated into UniProtKB/TrEMBL. DT 11-OCT-2005, sequence version 1. DT 24-JUN-2015, entry version 82. DE SubName: Full=Putative uncharacterized protein {ECO:0000313|EMBL:BAE23839.1}; DE Flags: Fragment; GN Name=Fzd6 {ECO:0000313|MGI:MGI:108474}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAE23839.1}; RN [1] {ECO:0000313|EMBL:BAE23839.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE23839.1}; RC TISSUE=Aorta and vein {ECO:0000313|EMBL:BAE23839.1}; RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9; RA Carninci P., Hayashizaki Y.; RT "High-efficiency full-length cDNA cloning."; RL Methods Enzymol. 303:19-44(1999). RN [2] {ECO:0000313|EMBL:BAE23839.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE23839.1}; RC TISSUE=Aorta and vein {ECO:0000313|EMBL:BAE23839.1}; RX PubMed=11042159; DOI=10.1101/gr.145100; RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.; RT "Normalization and subtraction of cap-trapper-selected cDNAs to RT prepare full-length cDNA libraries for rapid discovery of new genes."; RL Genome Res. 10:1617-1630(2000). RN [3] {ECO:0000313|EMBL:BAE23839.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE23839.1}; RC TISSUE=Aorta and vein {ECO:0000313|EMBL:BAE23839.1}; RX PubMed=11076861; DOI=10.1101/gr.152600; RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., RA Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., RA Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., RA Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., RA Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., RA Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.; RT "RIKEN integrated sequence analysis (RISA) system--384-format RT sequencing pipeline with 384 multicapillary sequencer."; RL Genome Res. 10:1757-1771(2000). RN [4] {ECO:0000313|EMBL:BAE23839.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE23839.1}; RC TISSUE=Aorta and vein {ECO:0000313|EMBL:BAE23839.1}; RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium; RT "Functional annotation of a full-length mouse cDNA collection."; RL Nature 409:685-690(2001). RN [5] {ECO:0000313|EMBL:BAE23839.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE23839.1}; RC TISSUE=Aorta and vein {ECO:0000313|EMBL:BAE23839.1}; RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). RN [6] {ECO:0000313|EMBL:BAE23839.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE23839.1}; RC TISSUE=Aorta and vein {ECO:0000313|EMBL:BAE23839.1}; RA Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., RA Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., RA Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., RA Nishiyori H., Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., RA Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., RA Muramatsu M., Hayashizaki Y.; RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:BAE23839.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE23839.1}; RC TISSUE=Aorta and vein {ECO:0000313|EMBL:BAE23839.1}; RG The FANTOM Consortium; RG Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group); RT "The Transcriptional Landscape of the Mammalian Genome."; RL Science 309:1559-1563(2005). RN [8] {ECO:0000313|EMBL:BAE23839.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE23839.1}; RC TISSUE=Aorta and vein {ECO:0000313|EMBL:BAE23839.1}; RX PubMed=16141073; DOI=10.1126/science.1112009; RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium; RT "Antisense Transcription in the Mammalian Transcriptome."; RL Science 309:1564-1566(2005). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK138964; BAE23839.1; -; mRNA. DR RefSeq; NP_001155966.1; NM_001162494.1. DR RefSeq; NP_032082.3; NM_008056.3. DR UniGene; Mm.4769; -. DR ProteinModelPortal; Q3UTZ0; -. DR STRING; 10090.ENSMUSP00000022906; -. DR PRIDE; Q3UTZ0; -. DR GeneID; 14368; -. DR KEGG; mmu:14368; -. DR CTD; 8323; -. DR MGI; MGI:108474; Fzd6. DR HOVERGEN; HBG006977; -. DR KO; K02376; -. DR ChiTaRS; Fzd6; mouse. DR NextBio; 285845; -. DR Bgee; Q3UTZ0; -. DR ExpressionAtlas; Q3UTZ0; baseline and differential. DR Genevisible; Q3UTZ0; MM. DR GO; GO:0045177; C:apical part of cell; IDA:MGI. DR GO; GO:0016327; C:apicolateral plasma membrane; IDA:MGI. DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central. DR GO; GO:0004930; F:G-protein coupled receptor activity; IBA:GO_Central. DR GO; GO:0031625; F:ubiquitin protein ligase binding; ISO:MGI. DR GO; GO:0042813; F:Wnt-activated receptor activity; ISO:MGI. DR GO; GO:0017147; F:Wnt-protein binding; IPI:MGI. DR GO; GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central. DR GO; GO:0033278; P:cell proliferation in midbrain; IGI:MGI. DR GO; GO:0035880; P:embryonic nail plate morphogenesis; IMP:MGI. DR GO; GO:0001736; P:establishment of planar polarity; IGI:MGI. DR GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IBA:GOC. DR GO; GO:0001942; P:hair follicle development; IMP:MGI. DR GO; GO:0042472; P:inner ear morphogenesis; IGI:MGI. DR GO; GO:0030901; P:midbrain development; IGI:MGI. DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; ISO:MGI. DR GO; GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; ISO:MGI. DR GO; GO:0001843; P:neural tube closure; IGI:MGI. DR GO; GO:0035567; P:non-canonical Wnt signaling pathway; ISO:MGI. DR GO; GO:0030168; P:platelet activation; IMP:MGI. DR GO; GO:0060071; P:Wnt signaling pathway, planar cell polarity pathway; IDA:MGI. DR InterPro; IPR000539; Frizzled. DR InterPro; IPR015526; Frizzled/SFRP. DR InterPro; IPR026543; FZD6. DR InterPro; IPR017981; GPCR_2-like. DR PANTHER; PTHR11309; PTHR11309; 1. DR PANTHER; PTHR11309:SF75; PTHR11309:SF75; 1. DR Pfam; PF01534; Frizzled; 1. DR PRINTS; PR00489; FRIZZLED. DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1. PE 2: Evidence at transcript level; FT NON_TER 1 1 {ECO:0000313|EMBL:BAE23839.1}. SQ SEQUENCE 386 AA; 42124 MW; 038413B4EDC0B2FB CRC64; AVWFHAVAWG APGFLTVMLL AMNKVEGDNI SGVCFVGLYD LDASRYFVLL PLCLCVFVGL SLLLAGIISL NHVRQVIQHD GRNQEKLKKF MIRIGVFSGL YLVPLVTLLG CYVYELVNRI TWEMTWFSDH CHQYRIPCPY QANPKARPEL ALFMIKYLMT LIVGISAVFW VGSKKTCTEW AGFFKRNRKR DPISESRRVL QESCEFFLKH NSKVKHKKKH GAPGPHRLKV ISKSMGTSTG ATTNHGTSAM AIADHDYLGQ ETSTEVHTSP EASVKEGRAD RANTPSAKDR DCGESAGPSS KLSGNRNGRE SRAGGLKERS NGSEGAPSEG RVSPKSSVPE TGLIDCSTSQ AASSPEPTSL KGSTSLPVHS ASRARKEQGA GSHSDA //