ID Q3UTZ0_MOUSE Unreviewed; 386 AA. AC Q3UTZ0; DT 11-OCT-2005, integrated into UniProtKB/TrEMBL. DT 11-OCT-2005, sequence version 1. DT 16-MAY-2012, entry version 57. DE SubName: Full=Putative uncharacterized protein; DE Flags: Fragment; GN Name=Fzd6; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Aorta and vein; RX MEDLINE=99279253; PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9; RA Carninci P., Hayashizaki Y.; RT "High-efficiency full-length cDNA cloning."; RL Methods Enzymol. 303:19-44(1999). RN [2] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Aorta and vein; RX MEDLINE=20499374; PubMed=11042159; DOI=10.1101/gr.145100; RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.; RT "Normalization and subtraction of cap-trapper-selected cDNAs to RT prepare full-length cDNA libraries for rapid discovery of new genes."; RL Genome Res. 10:1617-1630(2000). RN [3] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Aorta and vein; RX MEDLINE=20530913; PubMed=11076861; DOI=10.1101/gr.152600; RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., RA Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., RA Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., RA Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., RA Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., RA Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.; RT "RIKEN integrated sequence analysis (RISA) system--384-format RT sequencing pipeline with 384 multicapillary sequencer."; RL Genome Res. 10:1757-1771(2000). RN [4] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Aorta and vein; RG The RIKEN Genome Exploration Research Group Phase II Team and the RG FANTOM Consortium; RT "Functional annotation of a full-length mouse cDNA collection."; RL Nature 409:685-690(2001). RN [5] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Aorta and vein; RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group RG Phase I and II Team; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). RN [6] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Aorta and vein; RA Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., RA Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., RA Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., RA Nishiyori H., Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., RA Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., RA Muramatsu M., Hayashizaki Y.; RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Aorta and vein; RG The FANTOM Consortium, Riken Genome Exploration Research Group and RG Genome Science Group (Genome Network Project Core Group); RT "The Transcriptional Landscape of the Mammalian Genome."; RL Science 309:1559-1563(2005). RN [8] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Aorta and vein; RX PubMed=16141073; DOI=10.1126/science.1112009; RG RIKEN Genome Exploration Research Group and Genome Science Group RG (Genome Network Project Core Group) and the FANTOM Consortium; RT "Antisense Transcription in the Mammalian Transcriptome."; RL Science 309:1564-1566(2005). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK138964; BAE23839.1; -; mRNA. DR IPI; IPI00117095; -. DR RefSeq; NP_001155966.1; NM_001162494.1. DR RefSeq; NP_032082.3; NM_008056.3. DR UniGene; Mm.4769; -. DR STRING; Q3UTZ0; -. DR GeneID; 14368; -. DR KEGG; mmu:14368; -. DR CTD; 8323; -. DR MGI; MGI:108474; Fzd6. DR HOVERGEN; HBG006977; -. DR InParanoid; Q3UTZ0; -. DR KO; K02376; -. DR NextBio; 285845; -. DR ArrayExpress; Q3UTZ0; -. DR Bgee; Q3UTZ0; -. DR Genevestigator; Q3UTZ0; -. DR GO; GO:0045177; C:apical part of cell; IDA:MGI. DR GO; GO:0016327; C:apicolateral plasma membrane; IDA:MGI. DR GO; GO:0005737; C:cytoplasm; IBA:RefGenome. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0032589; C:neuron projection membrane; IBA:RefGenome. DR GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW. DR GO; GO:0030165; F:PDZ domain binding; IBA:RefGenome. DR GO; GO:0042813; F:Wnt-activated receptor activity; IBA:RefGenome. DR GO; GO:0017147; F:Wnt-protein binding; IPI:MGI. DR GO; GO:0001525; P:angiogenesis; IBA:RefGenome. DR GO; GO:0007409; P:axonogenesis; IBA:RefGenome. DR GO; GO:0060070; P:canonical Wnt receptor signaling pathway; IBA:RefGenome. DR GO; GO:0033278; P:cell proliferation in midbrain; IGI:MGI. DR GO; GO:0001736; P:establishment of planar polarity; IGI:MGI. DR GO; GO:0007199; P:G-protein signaling, coupled to cGMP nucleotide second messenger; IBA:RefGenome. DR GO; GO:0008406; P:gonad development; IBA:RefGenome. DR GO; GO:0001942; P:hair follicle development; IMP:MGI. DR GO; GO:0042472; P:inner ear morphogenesis; IGI:MGI. DR GO; GO:0001843; P:neural tube closure; IGI:MGI. DR GO; GO:0030168; P:platelet activation; IMP:MGI. DR GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IBA:RefGenome. DR GO; GO:0060071; P:Wnt receptor signaling pathway, planar cell polarity pathway; IDA:MGI. DR InterPro; IPR000539; Frizzled. DR InterPro; IPR015526; Frizzled-related. DR InterPro; IPR017981; GPCR_2-like. DR PANTHER; PTHR11309; Fz_related; 1. DR Pfam; PF01534; Frizzled; 1. DR PRINTS; PR00489; FRIZZLED. DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1. PE 2: Evidence at transcript level; KW Membrane; Receptor; Transmembrane; Transmembrane helix. FT NON_TER 1 1 SQ SEQUENCE 386 AA; 42124 MW; 038413B4EDC0B2FB CRC64; AVWFHAVAWG APGFLTVMLL AMNKVEGDNI SGVCFVGLYD LDASRYFVLL PLCLCVFVGL SLLLAGIISL NHVRQVIQHD GRNQEKLKKF MIRIGVFSGL YLVPLVTLLG CYVYELVNRI TWEMTWFSDH CHQYRIPCPY QANPKARPEL ALFMIKYLMT LIVGISAVFW VGSKKTCTEW AGFFKRNRKR DPISESRRVL QESCEFFLKH NSKVKHKKKH GAPGPHRLKV ISKSMGTSTG ATTNHGTSAM AIADHDYLGQ ETSTEVHTSP EASVKEGRAD RANTPSAKDR DCGESAGPSS KLSGNRNGRE SRAGGLKERS NGSEGAPSEG RVSPKSSVPE TGLIDCSTSQ AASSPEPTSL KGSTSLPVHS ASRARKEQGA GSHSDA //