ID Q3USX8_MOUSE Unreviewed; 203 AA. AC Q3USX8; DT 11-OCT-2005, integrated into UniProtKB/TrEMBL. DT 11-OCT-2005, sequence version 1. DT 20-JAN-2016, entry version 77. DE SubName: Full=Putative uncharacterized protein {ECO:0000313|EMBL:BAE24202.1}; GN Name=Ikbkb {ECO:0000313|MGI:MGI:1338071}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAE24202.1}; RN [1] {ECO:0000313|EMBL:BAE24202.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE24202.1}; RC TISSUE=Corpora quadrigemina {ECO:0000313|EMBL:BAE24202.1}; RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9; RA Carninci P., Hayashizaki Y.; RT "High-efficiency full-length cDNA cloning."; RL Methods Enzymol. 303:19-44(1999). RN [2] {ECO:0000313|EMBL:BAE24202.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE24202.1}; RC TISSUE=Corpora quadrigemina {ECO:0000313|EMBL:BAE24202.1}; RX PubMed=11042159; DOI=10.1101/gr.145100; RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.; RT "Normalization and subtraction of cap-trapper-selected cDNAs to RT prepare full-length cDNA libraries for rapid discovery of new genes."; RL Genome Res. 10:1617-1630(2000). RN [3] {ECO:0000313|EMBL:BAE24202.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE24202.1}; RC TISSUE=Corpora quadrigemina {ECO:0000313|EMBL:BAE24202.1}; RX PubMed=11076861; DOI=10.1101/gr.152600; RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., RA Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., RA Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., RA Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., RA Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., RA Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.; RT "RIKEN integrated sequence analysis (RISA) system--384-format RT sequencing pipeline with 384 multicapillary sequencer."; RL Genome Res. 10:1757-1771(2000). RN [4] {ECO:0000313|EMBL:BAE24202.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE24202.1}; RC TISSUE=Corpora quadrigemina {ECO:0000313|EMBL:BAE24202.1}; RX PubMed=11217851; DOI=10.1038/35055500; RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium; RT "Functional annotation of a full-length mouse cDNA collection."; RL Nature 409:685-690(2001). RN [5] {ECO:0000313|EMBL:BAE24202.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE24202.1}; RC TISSUE=Corpora quadrigemina {ECO:0000313|EMBL:BAE24202.1}; RX PubMed=12466851; DOI=10.1038/nature01266; RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). RN [6] {ECO:0000313|EMBL:BAE24202.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE24202.1}; RC TISSUE=Corpora quadrigemina {ECO:0000313|EMBL:BAE24202.1}; RA Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., RA Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., RA Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., RA Nishiyori H., Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., RA Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., RA Muramatsu M., Hayashizaki Y.; RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:BAE24202.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE24202.1}; RC TISSUE=Corpora quadrigemina {ECO:0000313|EMBL:BAE24202.1}; RG The FANTOM Consortium; RG Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group); RT "The Transcriptional Landscape of the Mammalian Genome."; RL Science 309:1559-1563(2005). RN [8] {ECO:0000313|EMBL:BAE24202.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE24202.1}; RC TISSUE=Corpora quadrigemina {ECO:0000313|EMBL:BAE24202.1}; RX PubMed=16141073; DOI=10.1126/science.1112009; RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium; RT "Antisense Transcription in the Mammalian Transcriptome."; RL Science 309:1564-1566(2005). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK139972; BAE24202.1; -; mRNA. DR UniGene; Mm.277886; -. DR STRING; 10090.ENSMUSP00000033939; -. DR PaxDb; Q3USX8; -. DR UCSC; uc009lds.2; mouse. DR MGI; MGI:1338071; Ikbkb. DR eggNOG; ENOG410XRMU; LUCA. DR eggNOG; KOG4250; Eukaryota. DR HOVERGEN; HBG085563; -. DR GO; GO:0005737; C:cytoplasm; ISO:MGI. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0008384; F:IkappaB kinase activity; IDA:MGI. DR GO; GO:0046982; F:protein heterodimerization activity; ISO:MGI. DR GO; GO:0042803; F:protein homodimerization activity; ISO:MGI. DR GO; GO:0004672; F:protein kinase activity; IDA:MGI. DR GO; GO:0019901; F:protein kinase binding; ISO:MGI. DR GO; GO:0004674; F:protein serine/threonine kinase activity; ISO:MGI. DR GO; GO:0004702; F:receptor signaling protein serine/threonine kinase activity; TAS:MGI. DR GO; GO:0097110; F:scaffold protein binding; ISO:MGI. DR GO; GO:0001782; P:B cell homeostasis; IMP:MGI. DR GO; GO:0071356; P:cellular response to tumor necrosis factor; ISO:MGI. DR GO; GO:0030866; P:cortical actin cytoskeleton organization; ISO:MGI. DR GO; GO:0090002; P:establishment of protein localization to plasma membrane; ISO:MGI. DR GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; ISO:MGI. DR GO; GO:0007252; P:I-kappaB phosphorylation; TAS:MGI. DR GO; GO:0070498; P:interleukin-1-mediated signaling pathway; ISO:MGI. DR GO; GO:1903347; P:negative regulation of bicellular tight junction assembly; ISO:MGI. DR GO; GO:0035509; P:negative regulation of myosin-light-chain-phosphatase activity; ISO:MGI. DR GO; GO:2001259; P:positive regulation of cation channel activity; IGI:MGI. DR GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISO:MGI. DR GO; GO:0010765; P:positive regulation of sodium ion transport; IGI:MGI. DR GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISO:MGI. DR GO; GO:0006468; P:protein phosphorylation; ISO:MGI. DR GO; GO:1903140; P:regulation of establishment of endothelial barrier; ISO:MGI. DR GO; GO:0042325; P:regulation of phosphorylation; ISO:MGI. DR GO; GO:0042501; P:serine phosphorylation of STAT protein; ISO:MGI. DR GO; GO:0023014; P:signal transduction by protein phosphorylation; TAS:GOC. DR GO; GO:0033209; P:tumor necrosis factor-mediated signaling pathway; ISO:MGI. DR InterPro; IPR011009; Kinase-like_dom. DR InterPro; IPR000719; Prot_kinase_dom. DR InterPro; IPR008271; Ser/Thr_kinase_AS. DR Pfam; PF00069; Pkinase; 1. DR SUPFAM; SSF56112; SSF56112; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1. PE 2: Evidence at transcript level; FT DOMAIN 15 203 Protein kinase. {ECO:0000259|PROSITE: FT PS50011}. SQ SEQUENCE 203 AA; 22972 MW; 8B27020D2C405057 CRC64; MSWSPSLPTQ TCGAWEMKER LGTGGFGNVI RWHNQATGEQ IAIKQCRQEL SPKNRDRWCL EIQIMRRLNH PNVVAARDVP EGMQNLAPND LPLLAMEYCQ GGDLRRYLNQ FENCCGLREG AVLTLLSDIA SALRYLHENR IIHRDLKPEN IVLQQGEKRL IHKIIDLGYA KELDQGSLCT SFVGTLQYLA PEASGAAEVH HDR //