ID Q3USD3_MOUSE Unreviewed; 228 AA. AC Q3USD3; DT 11-OCT-2005, integrated into UniProtKB/TrEMBL. DT 11-OCT-2005, sequence version 1. DT 27-NOV-2024, entry version 142. DE SubName: Full=MAX interacting protein 1 {ECO:0000313|EMBL:ABF48503.1}; GN Name=Mxi1 {ECO:0000313|EMBL:ABF48503.1, ECO:0000313|MGI:MGI:97245}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAE24400.1}; RN [1] {ECO:0000313|EMBL:BAE24400.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE24400.1}; RC TISSUE=Medulla oblongata {ECO:0000313|EMBL:BAE24400.1}; RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9; RA Carninci P., Hayashizaki Y.; RT "High-efficiency full-length cDNA cloning."; RL Methods Enzymol. 303:19-44(1999). RN [2] {ECO:0000313|EMBL:BAE24400.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE24400.1}; RC TISSUE=Medulla oblongata {ECO:0000313|EMBL:BAE24400.1}; RX PubMed=11042159; DOI=10.1101/gr.145100; RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.; RT "Normalization and subtraction of cap-trapper-selected cDNAs to prepare RT full-length cDNA libraries for rapid discovery of new genes."; RL Genome Res. 10:1617-1630(2000). RN [3] {ECO:0000313|EMBL:BAE24400.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE24400.1}; RC TISSUE=Medulla oblongata {ECO:0000313|EMBL:BAE24400.1}; RX PubMed=11076861; DOI=10.1101/gr.152600; RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., RA Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R., RA Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., RA Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., RA Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., RA Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.; RT "RIKEN integrated sequence analysis (RISA) system--384-format sequencing RT pipeline with 384 multicapillary sequencer."; RL Genome Res. 10:1757-1771(2000). RN [4] {ECO:0000313|EMBL:BAE24400.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE24400.1}; RC TISSUE=Medulla oblongata {ECO:0000313|EMBL:BAE24400.1}; RX PubMed=11217851; DOI=10.1038/35055500; RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium; RT "Functional annotation of a full-length mouse cDNA collection."; RL Nature 409:685-690(2001). RN [5] {ECO:0000313|EMBL:BAE24400.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE24400.1}; RC TISSUE=Medulla oblongata {ECO:0000313|EMBL:BAE24400.1}; RX PubMed=12466851; DOI=10.1038/nature01266; RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). RN [6] {ECO:0000313|EMBL:BAE24400.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE24400.1}; RC TISSUE=Medulla oblongata {ECO:0000313|EMBL:BAE24400.1}; RA Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., RA Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., RA Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H., Nomura K., RA Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., RA Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.; RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:BAE24400.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE24400.1}; RC TISSUE=Medulla oblongata {ECO:0000313|EMBL:BAE24400.1}; RG The FANTOM Consortium; RG Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group); RT "The Transcriptional Landscape of the Mammalian Genome."; RL Science 309:1559-1563(2005). RN [8] {ECO:0000313|EMBL:BAE24400.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE24400.1}; RC TISSUE=Medulla oblongata {ECO:0000313|EMBL:BAE24400.1}; RX PubMed=16141073; DOI=10.1126/science.1112009; RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium; RT "Antisense Transcription in the Mammalian Transcriptome."; RL Science 309:1564-1566(2005). RN [9] {ECO:0000313|EMBL:ABF48503.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BTBR T+ tf/J {ECO:0000313|EMBL:ABF48503.1}; RX PubMed=16682971; DOI=10.1038/ng1796; RA Clee S.M., Yandell B.S., Schueler K.M., Rabaglia M.E., Richards O.C., RA Raines S.M., Kabara E.A., Klass D.M., Mui E.T.-K., Stapleton D.S., RA Gray-Keller M.P., Young M.B., Stoehr J.P., Lan H., Boronenkov I., RA Raess P.W., Flowers M.T., Attie A.D.; RT "Positional cloning of Sorcs1, a type 2 diabetes quantitative trait RT locus."; RL Nat. Genet. 38:688-693(2006). CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ479924; ABF48503.1; -; Genomic_DNA. DR EMBL; AK140465; BAE24400.1; -; mRNA. DR RefSeq; NP_034977.1; NM_010847.3. DR AlphaFoldDB; Q3USD3; -. DR SMR; Q3USD3; -. DR Antibodypedia; 18346; 242 antibodies from 29 providers. DR DNASU; 17859; -. DR GeneID; 17859; -. DR KEGG; mmu:17859; -. DR AGR; MGI:97245; -. DR CTD; 4601; -. DR MGI; MGI:97245; Mxi1. DR VEuPathDB; HostDB:ENSMUSG00000025025; -. DR OMA; VEMINIQ; -. DR OrthoDB; 5402993at2759; -. DR BioGRID-ORCS; 17859; 4 hits in 80 CRISPR screens. DR ChiTaRS; Mxi1; mouse. DR ExpressionAtlas; Q3USD3; baseline and differential. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro. DR CDD; cd18930; bHLHzip_MXI1; 1. DR FunFam; 4.10.280.10:FF:000014; Max dimerization protein 1; 1. DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1. DR InterPro; IPR011598; bHLH_dom. DR InterPro; IPR036638; HLH_DNA-bd_sf. DR PANTHER; PTHR11969; MAX DIMERIZATION, MAD; 1. DR PANTHER; PTHR11969:SF13; MAX-INTERACTING PROTEIN 1; 1. DR Pfam; PF00010; HLH; 1. DR SMART; SM00353; HLH; 1. DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1. DR PROSITE; PS50888; BHLH; 1. PE 2: Evidence at transcript level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242}; KW Repressor {ECO:0000256|ARBA:ARBA00022491}; KW Transcription {ECO:0000256|ARBA:ARBA00023163}; KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}. FT DOMAIN 67..119 FT /note="BHLH" FT /evidence="ECO:0000259|PROSITE:PS50888" FT REGION 30..76 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 160..228 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 109..150 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 54..71 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 168..187 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 188..228 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 228 AA; 25978 MW; 7B5D4ACAEF97C4F1 CRC64; MERVRMINVQ RLLEAAEFLE RRERECEHGY ASSFPSMPSP RLQHSKPPRR LSRAQKHSSG SSNTSTANRS THNELEKNRR AHLRLCLERL KVLIPLGPDC TRHTTLGLLN KAKAHIKKLE EAERKSQHQL ENLEREQRFL KRRLEQLQGP QEMERIRMDS IGSTISSDRS DSEREEIEVD VESTEFSHGE ADSVSTTSIS DLDDHSSLQS VGSDEGYSSA SVKLSFAS //