ID Q3UN87_MOUSE Unreviewed; 240 AA. AC Q3UN87; DT 11-OCT-2005, integrated into UniProtKB/TrEMBL. DT 11-OCT-2005, sequence version 1. DT 22-FEB-2023, entry version 139. DE RecName: Full=Small nuclear ribonucleoprotein-associated protein {ECO:0000256|PIRNR:PIRNR037187}; GN Name=Snrpn {ECO:0000313|MGI:MGI:98347}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAE25860.1}; RN [1] {ECO:0000313|EMBL:AAA09579.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=1627828; RA Grimaldi K., Gerrelli D., Sharpe N.G., Lund T., Latchman D.S.; RT "The intronless mouse gene for the tissue specific splicing protein SmN is RT a processed pseudogene containing a stop codon after thirty-one amino RT acids."; RL DNA Seq. 2:241-246(1992). RN [2] {ECO:0000313|EMBL:BAE25860.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE25860.1}; RC TISSUE=Spinal cord {ECO:0000313|EMBL:BAE25860.1}; RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9; RA Carninci P., Hayashizaki Y.; RT "High-efficiency full-length cDNA cloning."; RL Methods Enzymol. 303:19-44(1999). RN [3] {ECO:0000313|EMBL:BAE25860.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE25860.1}; RC TISSUE=Spinal cord {ECO:0000313|EMBL:BAE25860.1}; RX PubMed=11042159; DOI=10.1101/gr.145100; RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.; RT "Normalization and subtraction of cap-trapper-selected cDNAs to prepare RT full-length cDNA libraries for rapid discovery of new genes."; RL Genome Res. 10:1617-1630(2000). RN [4] {ECO:0000313|EMBL:BAE25860.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE25860.1}; RC TISSUE=Spinal cord {ECO:0000313|EMBL:BAE25860.1}; RX PubMed=11076861; DOI=10.1101/gr.152600; RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., RA Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R., RA Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., RA Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., RA Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., RA Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.; RT "RIKEN integrated sequence analysis (RISA) system--384-format sequencing RT pipeline with 384 multicapillary sequencer."; RL Genome Res. 10:1757-1771(2000). RN [5] {ECO:0000313|EMBL:BAE25860.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE25860.1}; RC TISSUE=Spinal cord {ECO:0000313|EMBL:BAE25860.1}; RX PubMed=11217851; DOI=10.1038/35055500; RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium; RT "Functional annotation of a full-length mouse cDNA collection."; RL Nature 409:685-690(2001). RN [6] {ECO:0000313|EMBL:BAE25860.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE25860.1}; RC TISSUE=Spinal cord {ECO:0000313|EMBL:BAE25860.1}; RX PubMed=12466851; DOI=10.1038/nature01266; RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). RN [7] {ECO:0000313|EMBL:BAE25860.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE25860.1}; RC TISSUE=Spinal cord {ECO:0000313|EMBL:BAE25860.1}; RA Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., RA Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., RA Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H., Nomura K., RA Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., RA Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.; RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|EMBL:BAE25860.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE25860.1}; RC TISSUE=Spinal cord {ECO:0000313|EMBL:BAE25860.1}; RG The FANTOM Consortium; RG Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group); RT "The Transcriptional Landscape of the Mammalian Genome."; RL Science 309:1559-1563(2005). RN [9] {ECO:0000313|EMBL:BAE25860.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE25860.1}; RC TISSUE=Spinal cord {ECO:0000313|EMBL:BAE25860.1}; RX PubMed=16141073; DOI=10.1126/science.1112009; RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium; RT "Antisense Transcription in the Mammalian Transcriptome."; RL Science 309:1564-1566(2005). CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123, CC ECO:0000256|PIRNR:PIRNR037187}. CC -!- SIMILARITY: Belongs to the snRNP SmB/SmN family. CC {ECO:0000256|ARBA:ARBA00009123, ECO:0000256|PIRNR:PIRNR037187}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; S40304; AAA09579.1; -; mRNA. DR EMBL; AK144386; BAE25860.1; -; mRNA. DR RefSeq; NP_001076430.1; NM_001082961.1. DR RefSeq; NP_001076431.1; NM_001082962.1. DR RefSeq; NP_038698.1; NM_013670.3. DR AlphaFoldDB; Q3UN87; -. DR SMR; Q3UN87; -. DR MaxQB; Q3UN87; -. DR Antibodypedia; 22280; 164 antibodies from 26 providers. DR DNASU; 20646; -. DR GeneID; 20646; -. DR KEGG; mmu:20646; -. DR AGR; MGI:98347; -. DR CTD; 6638; -. DR MGI; MGI:98347; Snrpn. DR VEuPathDB; HostDB:ENSMUSG00000102252; -. DR HOGENOM; CLU_076902_1_0_1; -. DR OMA; FAPQRPG; -. DR OrthoDB; 5475294at2759; -. DR BioGRID-ORCS; 20646; 3 hits in 83 CRISPR screens. DR ChiTaRS; Snrpn; mouse. DR ExpressionAtlas; Q3UN87; baseline and differential. DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl. DR GO; GO:0005685; C:U1 snRNP; IEA:Ensembl. DR GO; GO:0005686; C:U2 snRNP; IEA:Ensembl. DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW. DR GO; GO:0009725; P:response to hormone; IEA:Ensembl. DR CDD; cd01717; Sm_B; 1. DR Gene3D; 2.30.30.100; -; 1. DR InterPro; IPR001163; LSM_dom_euk/arc. DR InterPro; IPR010920; LSM_dom_sf. DR InterPro; IPR017131; snRNP-assoc_SmB/SmN. DR PANTHER; PTHR10701; SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N; 1. DR PANTHER; PTHR10701:SF24; SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN N; 1. DR Pfam; PF01423; LSM; 1. DR PIRSF; PIRSF037187; snRNP_SmB/SmN; 1. DR SMART; SM00651; Sm; 1. DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1. PE 2: Evidence at transcript level; KW Nucleus {ECO:0000256|PIRNR:PIRNR037187}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274, KW ECO:0000256|PIRNR:PIRNR037187}; KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PIRNR:PIRNR037187}. FT DOMAIN 7..82 FT /note="LSM" FT /evidence="ECO:0000259|SMART:SM00651" FT REGION 163..240 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 169..240 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 240 AA; 24614 MW; 9A176D043561474C CRC64; MTVGKSSKML QHIDYRMRCI LQDGRIFIGT FKAFDKHMNL ILCDCDEFRK IKPKNAKQPE REEKRVLGLV LLRGENLVSM TVEGPPPKDT GIARVPLAGA AGGPGVGRAA GRGVPAGVPI PQAPAGLAGP VRGVGGPSQQ VMTPQGRGTV AAAAVAATAS IAGAPTQYPP GRGTPPPPVG RATPPPGIMA PPPGMRPPMG PPIGLPPARG TPIGMPPPGM RPPPPGIRGP PPPGMRPPRP //