ID Q3U9G8_MOUSE Unreviewed; 229 AA. AC Q3U9G8; DT 11-OCT-2005, integrated into UniProtKB/TrEMBL. DT 11-OCT-2005, sequence version 1. DT 31-JAN-2018, entry version 113. DE SubName: Full=Apolipoprotein B editing complex 1, isoform CRA_a {ECO:0000313|EMBL:EDK99689.1}; GN Name=Apobec1 {ECO:0000313|EMBL:EDK99689.1, GN ECO:0000313|MGI:MGI:103298}; GN ORFNames=mCG_132204 {ECO:0000313|EMBL:EDK99689.1}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAE30699.1}; RN [1] {ECO:0000313|EMBL:BAE30699.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE30699.1}, and DBA/2 RC {ECO:0000313|EMBL:BAE27161.1}; RC TISSUE=Bone marrow {ECO:0000313|EMBL:BAE30699.1}, and Spleen RC {ECO:0000313|EMBL:BAE38079.1}; RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9; RA Carninci P., Hayashizaki Y.; RT "High-efficiency full-length cDNA cloning."; RL Methods Enzymol. 303:19-44(1999). RN [2] {ECO:0000313|EMBL:BAE30699.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE30699.1}, and DBA/2 RC {ECO:0000313|EMBL:BAE27161.1}; RC TISSUE=Bone marrow {ECO:0000313|EMBL:BAE30699.1}, and Spleen RC {ECO:0000313|EMBL:BAE38079.1}; RX PubMed=11042159; DOI=10.1101/gr.145100; RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.; RT "Normalization and subtraction of cap-trapper-selected cDNAs to RT prepare full-length cDNA libraries for rapid discovery of new genes."; RL Genome Res. 10:1617-1630(2000). RN [3] {ECO:0000313|EMBL:BAE30699.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE30699.1}, and DBA/2 RC {ECO:0000313|EMBL:BAE27161.1}; RC TISSUE=Bone marrow {ECO:0000313|EMBL:BAE30699.1}, and Spleen RC {ECO:0000313|EMBL:BAE38079.1}; RX PubMed=11076861; DOI=10.1101/gr.152600; RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., RA Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., RA Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., RA Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., RA Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., RA Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.; RT "RIKEN integrated sequence analysis (RISA) system--384-format RT sequencing pipeline with 384 multicapillary sequencer."; RL Genome Res. 10:1757-1771(2000). RN [4] {ECO:0000313|EMBL:BAE30699.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE30699.1}, and DBA/2 RC {ECO:0000313|EMBL:BAE27161.1}; RC TISSUE=Bone marrow {ECO:0000313|EMBL:BAE30699.1}, and Spleen RC {ECO:0000313|EMBL:BAE38079.1}; RX PubMed=11217851; DOI=10.1038/35055500; RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium; RT "Functional annotation of a full-length mouse cDNA collection."; RL Nature 409:685-690(2001). RN [5] {ECO:0000313|EMBL:BAE30699.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE30699.1}, and DBA/2 RC {ECO:0000313|EMBL:BAE27161.1}; RC TISSUE=Bone marrow {ECO:0000313|EMBL:BAE30699.1}, and Spleen RC {ECO:0000313|EMBL:BAE38079.1}; RX PubMed=12466851; DOI=10.1038/nature01266; RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). RN [6] {ECO:0000313|EMBL:EDK99689.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed {ECO:0000313|EMBL:EDK99689.1}; RX PubMed=12040188; DOI=10.1126/science.1069193; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., RA Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., RA Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W., RA Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., RA Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., RA Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., RA Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., RA Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., RA Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., RA Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., RA Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., RA Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., RA Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., RA Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., RA Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., RA Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., RA Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., RA Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., RA Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., RA Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., RA Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., RA Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., RA Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., RA Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., RA Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., RA Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., RA Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., RA Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., RA Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., RA Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., RA Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., RA Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.; RT "A comparison of whole-genome shotgun-derived mouse chromosome 16 and RT the human genome."; RL Science 296:1661-1671(2002). RN [7] {ECO:0000313|EMBL:BAE30699.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE30699.1}, and DBA/2 RC {ECO:0000313|EMBL:BAE27161.1}; RC TISSUE=Bone marrow {ECO:0000313|EMBL:BAE30699.1}; RA Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., RA Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., RA Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., RA Nishiyori H., Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., RA Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., RA Muramatsu M., Hayashizaki Y.; RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|EMBL:BAE38079.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE38079.1}; RC TISSUE=Spleen {ECO:0000313|EMBL:BAE38079.1}; RA Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., RA Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., RA Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., RA Nishiyori H., Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., RA Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., RA Muramatsu M., Hayashizaki Y.; RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:BAE30699.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE30699.1}, and DBA/2 RC {ECO:0000313|EMBL:BAE27161.1}; RC TISSUE=Bone marrow {ECO:0000313|EMBL:BAE30699.1}, and Spleen RC {ECO:0000313|EMBL:BAE38079.1}; RG The FANTOM Consortium; RG Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group); RT "The Transcriptional Landscape of the Mammalian Genome."; RL Science 309:1559-1563(2005). RN [10] {ECO:0000313|EMBL:BAE30699.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE30699.1}, and DBA/2 RC {ECO:0000313|EMBL:BAE27161.1}; RC TISSUE=Bone marrow {ECO:0000313|EMBL:BAE30699.1}, and Spleen RC {ECO:0000313|EMBL:BAE38079.1}; RX PubMed=16141073; DOI=10.1126/science.1112009; RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium; RT "Antisense Transcription in the Mammalian Transcriptome."; RL Science 309:1564-1566(2005). RN [11] {ECO:0000313|EMBL:EDK99689.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed {ECO:0000313|EMBL:EDK99689.1}; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK146427; BAE27161.1; -; mRNA. DR EMBL; AK151799; BAE30699.1; -; mRNA. DR EMBL; AK165209; BAE38079.1; -; mRNA. DR EMBL; CH466523; EDK99689.1; -; Genomic_DNA. DR EMBL; CH466523; EDK99691.1; -; Genomic_DNA. DR RefSeq; NP_001127863.1; NM_001134391.1. DR RefSeq; NP_112436.1; NM_031159.3. DR RefSeq; XP_006505464.1; XM_006505401.2. DR RefSeq; XP_011239461.1; XM_011241159.2. DR UniGene; Mm.3333; -. DR SMR; Q3U9G8; -. DR GeneID; 11810; -. DR KEGG; mmu:11810; -. DR CTD; 339; -. DR MGI; MGI:103298; Apobec1. DR eggNOG; ENOG410IKDF; Eukaryota. DR eggNOG; ENOG4111BJA; LUCA. DR HOVERGEN; HBG050445; -. DR KO; K16932; -. DR OMA; NFVNYPP; -. DR OrthoDB; EOG091G0PT8; -. DR Bgee; ENSMUSG00000040613; -. DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl. DR GO; GO:0005634; C:nucleus; IEA:Ensembl. DR GO; GO:0017091; F:AU-rich element binding; IEA:Ensembl. DR GO; GO:0004126; F:cytidine deaminase activity; IEA:Ensembl. DR GO; GO:0004131; F:cytosine deaminase activity; IEA:Ensembl. DR GO; GO:0008047; F:enzyme activator activity; IEA:Ensembl. DR GO; GO:0003729; F:mRNA binding; IEA:Ensembl. DR GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl. DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:Ensembl. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0032869; P:cellular response to insulin stimulus; IEA:Ensembl. DR GO; GO:0016554; P:cytidine to uridine editing; IEA:Ensembl. DR GO; GO:0051607; P:defense response to virus; IEA:Ensembl. DR GO; GO:0070383; P:DNA cytosine deamination; IEA:Ensembl. DR GO; GO:0080111; P:DNA demethylation; IEA:Ensembl. DR GO; GO:0042158; P:lipoprotein biosynthetic process; IEA:Ensembl. DR GO; GO:0042953; P:lipoprotein transport; IEA:Ensembl. DR GO; GO:0016556; P:mRNA modification; IEA:Ensembl. DR GO; GO:0048255; P:mRNA stabilization; IEA:Ensembl. DR GO; GO:0090310; P:negative regulation of methylation-dependent chromatin silencing; IEA:Ensembl. DR GO; GO:0090209; P:negative regulation of triglyceride metabolic process; IEA:Ensembl. DR GO; GO:0090366; P:positive regulation of mRNA modification; IEA:Ensembl. DR GO; GO:0042127; P:regulation of cell proliferation; IEA:Ensembl. DR GO; GO:0051592; P:response to calcium ion; IEA:Ensembl. DR GO; GO:0042493; P:response to drug; IEA:Ensembl. DR GO; GO:0045471; P:response to ethanol; IEA:Ensembl. DR GO; GO:0010332; P:response to gamma radiation; IEA:Ensembl. DR GO; GO:0006970; P:response to osmotic stress; IEA:Ensembl. DR GO; GO:0010043; P:response to zinc ion; IEA:Ensembl. DR GO; GO:0006641; P:triglyceride metabolic process; IEA:Ensembl. DR InterPro; IPR016192; APOBEC/CMP_deaminase_Zn-bd. DR InterPro; IPR013158; APOBEC_N. DR InterPro; IPR002125; CMP_dCMP_dom. DR InterPro; IPR016193; Cytidine_deaminase-like. DR Pfam; PF08210; APOBEC_N; 1. DR SUPFAM; SSF53927; SSF53927; 1. DR PROSITE; PS00903; CYT_DCMP_DEAMINASES_1; 1. DR PROSITE; PS51747; CYT_DCMP_DEAMINASES_2; 1. PE 2: Evidence at transcript level; KW Lipoprotein {ECO:0000313|EMBL:EDK99689.1}. FT DOMAIN 10 134 CMP/dCMP-type deaminase. FT {ECO:0000259|PROSITE:PS51747}. SQ SEQUENCE 229 AA; 27522 MW; 1CBCF9929066ABAD CRC64; MSSETGPVAV DPTLRRRIEP HEFEVFFDPR ELRKETCLLY EINWGGRHSV WRHTSQNTSN HVEVNFLEKF TTERYFRPNT RCSITWFLSW SPCGECSRAI TEFLSRHPYV TLFIYIARLY HHTDQRNRQG LRDLISSGVT IQIMTEQEYC YCWRNFVNYP PSNEAYWPRY PHLWVKLYVL ELYCIILGLP PCLKILRRKQ PQLTFFTITL QTCHYQRIPP HLLWATGLK //