ID Q3TWK2_MOUSE Unreviewed; 784 AA. AC Q3TWK2; DT 11-OCT-2005, integrated into UniProtKB/TrEMBL. DT 11-OCT-2005, sequence version 1. DT 19-JAN-2022, entry version 97. DE RecName: Full=Integrin_alpha2 domain-containing protein {ECO:0000259|Pfam:PF08441}; DE Flags: Fragment; GN Name=Itga6 {ECO:0000313|MGI:MGI:96605}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAE35264.1}; RN [1] {ECO:0000313|EMBL:BAE35264.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE35264.1}; RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9; RA Carninci P., Hayashizaki Y.; RT "High-efficiency full-length cDNA cloning."; RL Methods Enzymol. 303:19-44(1999). RN [2] {ECO:0000313|EMBL:BAE35264.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE35264.1}; RX PubMed=11042159; DOI=10.1101/gr.145100; RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.; RT "Normalization and subtraction of cap-trapper-selected cDNAs to prepare RT full-length cDNA libraries for rapid discovery of new genes."; RL Genome Res. 10:1617-1630(2000). RN [3] {ECO:0000313|EMBL:BAE35264.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE35264.1}; RX PubMed=11076861; DOI=10.1101/gr.152600; RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., RA Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R., RA Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., RA Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., RA Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., RA Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.; RT "RIKEN integrated sequence analysis (RISA) system--384-format sequencing RT pipeline with 384 multicapillary sequencer."; RL Genome Res. 10:1757-1771(2000). RN [4] {ECO:0000313|EMBL:BAE35264.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE35264.1}; RX PubMed=11217851; DOI=10.1038/35055500; RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium; RT "Functional annotation of a full-length mouse cDNA collection."; RL Nature 409:685-690(2001). RN [5] {ECO:0000313|EMBL:BAE35264.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE35264.1}; RX PubMed=12466851; DOI=10.1038/nature01266; RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). RN [6] {ECO:0000313|EMBL:BAE35264.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE35264.1}; RA Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., RA Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., RA Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H., Nomura K., RA Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., RA Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.; RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:BAE35264.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE35264.1}; RG The FANTOM Consortium; RG Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group); RT "The Transcriptional Landscape of the Mammalian Genome."; RL Science 309:1559-1563(2005). RN [8] {ECO:0000313|EMBL:BAE35264.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE35264.1}; RX PubMed=16141073; DOI=10.1126/science.1112009; RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium; RT "Antisense Transcription in the Mammalian Transcriptome."; RL Science 309:1564-1566(2005). CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479, CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}. CC -!- SIMILARITY: Belongs to the integrin alpha chain family. CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK159653; BAE35264.1; -; mRNA. DR PeptideAtlas; Q3TWK2; -. DR UCSC; uc008kbe.1; mouse. DR MGI; MGI:96605; Itga6. DR ChiTaRS; Itga6; mouse. DR GO; GO:0008305; C:integrin complex; IEA:InterPro. DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW. DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW. DR Gene3D; 2.130.10.130; -; 1. DR InterPro; IPR013517; FG-GAP. DR InterPro; IPR013519; Int_alpha_beta-p. DR InterPro; IPR000413; Integrin_alpha. DR InterPro; IPR013649; Integrin_alpha-2. DR InterPro; IPR028994; Integrin_alpha_N. DR InterPro; IPR032695; Integrin_dom_sf. DR Pfam; PF13517; FG-GAP_3; 1. DR Pfam; PF08441; Integrin_alpha2; 1. DR PRINTS; PR01185; INTEGRINA. DR SMART; SM00191; Int_alpha; 3. DR SUPFAM; SSF69179; SSF69179; 3. DR SUPFAM; SSF69318; SSF69318; 1. DR PROSITE; PS51470; FG_GAP; 3. PE 2: Evidence at transcript level; KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889, KW ECO:0000256|RuleBase:RU003762}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762}; KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW Signal {ECO:0000256|ARBA:ARBA00022729}; KW Transmembrane {ECO:0000256|RuleBase:RU003762}; KW Transmembrane helix {ECO:0000256|RuleBase:RU003762}. FT TRANSMEM 725..749 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU003762" FT REPEAT 13..75 FT /note="FG-GAP" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803" FT REPEAT 76..131 FT /note="FG-GAP" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803" FT REPEAT 132..191 FT /note="FG-GAP" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803" FT DOMAIN 176..651 FT /note="Integrin_alpha2" FT /evidence="ECO:0000259|Pfam:PF08441" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:BAE35264.1" SQ SEQUENCE 784 AA; 87609 MW; 7F14151D22EA192C CRC64; VVLLKRDMKS AHLLPEYIFD GEGLASSFGY DVAVVDLNAD GWQDIVIGAP QYFDRDGEVG GAVYVYINQQ GKWSNVKPIR LNGTKDSMFG ISVKNIGDIN QDGYPDIAVG APYDDLGKVF IYHGSPTGII TKPTQVLEGT SPYFGYSIAG NMDLDRNSYP DLAVGSLSDS VTIFRSRPVI NILKTITVTP NRIDLRQKSM CGSPSGICLK VKACFEYTAK PSGYNPPISI LGILEAEKER RKSGLSSRVQ FRNQGSEPKY TQELTLNRQK QRACMEETLW LQENIRDKLR PIPITASVEI QEPSSRRRVN SLPEVLPILN SNEAKTVQTD VHFLKEGCGD DNVCNSNLKL EYKFGTREGN QDKFSYLPIQ KGIPELVLKD QKDIALEITV TNSPSDPRNP RKDGDDAHEA KLIATFPDTL TYSAYRELRA FPEKQLSCVA NQNGSQADCE LGNPFKRNSS VTFYLILSTT EVTFDTTDLD INLKLETTSN QDNLAPITAK AKVVIELLLS VSGVAKPSQV YFGGTVVGEQ AMKSEDEVGS LIEYEFRVIN LGKPLKNLGT ATLNIQWPKE ISNGKWLLYL MKVESKGLEQ IVCEPHNEIN YLKLKESHNS RKKRDLPEKQ IDDSRKFSLF PERKYQTLNC SVNVRCVNIR CPLRGLDSKA SLVLRSRLWN STFLEEYSKL NYLDILLRAS IDVTAAAQNI KLPHAGTQVR VTVFPSKTVA QYSGVAWWII LLAVLAGILM LALLVFLLWK VQRFSPVSSR REHGSIQAGL VQEELRIVHL VLKV //