ID   Q3TWK2_MOUSE            Unreviewed;       784 AA.
AC   Q3TWK2;
DT   11-OCT-2005, integrated into UniProtKB/TrEMBL.
DT   11-OCT-2005, sequence version 1.
DT   31-JUL-2019, entry version 91.
DE   RecName: Full=Integrin_alpha2 domain-containing protein {ECO:0000259|Pfam:PF08441};
DE   Flags: Fragment;
GN   Name=Itga6 {ECO:0000313|MGI:MGI:96605};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:BAE35264.1};
RN   [1] {ECO:0000313|EMBL:BAE35264.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE35264.1};
RX   PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
RA   Carninci P., Hayashizaki Y.;
RT   "High-efficiency full-length cDNA cloning.";
RL   Methods Enzymol. 303:19-44(1999).
RN   [2] {ECO:0000313|EMBL:BAE35264.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE35264.1};
RX   PubMed=11042159; DOI=10.1101/gr.145100;
RA   Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
RA   Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
RT   "Normalization and subtraction of cap-trapper-selected cDNAs to
RT   prepare full-length cDNA libraries for rapid discovery of new genes.";
RL   Genome Res. 10:1617-1630(2000).
RN   [3] {ECO:0000313|EMBL:BAE35264.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE35264.1};
RX   PubMed=11076861; DOI=10.1101/gr.152600;
RA   Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
RA   Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M.,
RA   Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A.,
RA   Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K.,
RA   Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M.,
RA   Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J.,
RA   Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
RT   "RIKEN integrated sequence analysis (RISA) system--384-format
RT   sequencing pipeline with 384 multicapillary sequencer.";
RL   Genome Res. 10:1757-1771(2000).
RN   [4] {ECO:0000313|EMBL:BAE35264.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE35264.1};
RX   PubMed=11217851; DOI=10.1038/35055500;
RG   The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium;
RT   "Functional annotation of a full-length mouse cDNA collection.";
RL   Nature 409:685-690(2001).
RN   [5] {ECO:0000313|EMBL:BAE35264.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE35264.1};
RX   PubMed=12466851; DOI=10.1038/nature01266;
RG   The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team;
RT   "Analysis of the mouse transcriptome based on functional annotation of
RT   60,770 full-length cDNAs.";
RL   Nature 420:563-573(2002).
RN   [6] {ECO:0000313|EMBL:BAE35264.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE35264.1};
RA   Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K.,
RA   Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S.,
RA   Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N.,
RA   Nishiyori H., Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D.,
RA   Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A.,
RA   Muramatsu M., Hayashizaki Y.;
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|EMBL:BAE35264.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE35264.1};
RG   The FANTOM Consortium;
RG   Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group);
RT   "The Transcriptional Landscape of the Mammalian Genome.";
RL   Science 309:1559-1563(2005).
RN   [8] {ECO:0000313|EMBL:BAE35264.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE35264.1};
RX   PubMed=16141073; DOI=10.1126/science.1112009;
RG   RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium;
RT   "Antisense Transcription in the Mammalian Transcriptome.";
RL   Science 309:1564-1566(2005).
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta subunit.
CC       {ECO:0000256|SAAS:SAAS01130601}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003762};
CC       Single-pass type I membrane protein
CC       {ECO:0000256|RuleBase:RU003762}.
CC   -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC       {ECO:0000256|RuleBase:RU003762, ECO:0000256|SAAS:SAAS00554416}.
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DR   EMBL; AK159653; BAE35264.1; -; mRNA.
DR   PeptideAtlas; Q3TWK2; -.
DR   PRIDE; Q3TWK2; -.
DR   UCSC; uc008kbe.1; mouse.
DR   MGI; MGI:96605; Itga6.
DR   eggNOG; KOG3637; Eukaryota.
DR   eggNOG; ENOG410XPVZ; LUCA.
DR   GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.130; -; 1.
DR   InterPro; IPR013519; Int_alpha_beta-p.
DR   InterPro; IPR000413; Integrin_alpha.
DR   InterPro; IPR013649; Integrin_alpha-2.
DR   InterPro; IPR028994; Integrin_alpha_N.
DR   InterPro; IPR032695; Integrin_dom_sf.
DR   Pfam; PF08441; Integrin_alpha2; 1.
DR   PRINTS; PR01185; INTEGRINA.
DR   SMART; SM00191; Int_alpha; 3.
DR   SUPFAM; SSF69179; SSF69179; 3.
DR   PROSITE; PS51470; FG_GAP; 3.
PE   2: Evidence at transcript level;
KW   Cell adhesion {ECO:0000256|RuleBase:RU003762,
KW   ECO:0000256|SAAS:SAAS00440260};
KW   Integrin {ECO:0000256|RuleBase:RU003762,
KW   ECO:0000256|SAAS:SAAS00414648};
KW   Membrane {ECO:0000256|RuleBase:RU003762,
KW   ECO:0000256|SAAS:SAAS00414656};
KW   Receptor {ECO:0000256|RuleBase:RU003762,
KW   ECO:0000256|SAAS:SAAS00440269};
KW   Repeat {ECO:0000256|SAAS:SAAS00048613};
KW   Transmembrane {ECO:0000256|RuleBase:RU003762,
KW   ECO:0000256|SAAS:SAAS00494686};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU003762,
KW   ECO:0000256|SAAS:SAAS00414628}.
FT   TRANSMEM    725    749       Helical. {ECO:0000256|RuleBase:RU003762}.
FT   REPEAT       13     75       FG-GAP. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00803}.
FT   REPEAT       76    131       FG-GAP. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00803}.
FT   REPEAT      132    191       FG-GAP. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00803}.
FT   DOMAIN      176    651       Integrin_alpha2. {ECO:0000259|Pfam:
FT                                PF08441}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:BAE35264.1}.
SQ   SEQUENCE   784 AA;  87609 MW;  7F14151D22EA192C CRC64;
     VVLLKRDMKS AHLLPEYIFD GEGLASSFGY DVAVVDLNAD GWQDIVIGAP QYFDRDGEVG
     GAVYVYINQQ GKWSNVKPIR LNGTKDSMFG ISVKNIGDIN QDGYPDIAVG APYDDLGKVF
     IYHGSPTGII TKPTQVLEGT SPYFGYSIAG NMDLDRNSYP DLAVGSLSDS VTIFRSRPVI
     NILKTITVTP NRIDLRQKSM CGSPSGICLK VKACFEYTAK PSGYNPPISI LGILEAEKER
     RKSGLSSRVQ FRNQGSEPKY TQELTLNRQK QRACMEETLW LQENIRDKLR PIPITASVEI
     QEPSSRRRVN SLPEVLPILN SNEAKTVQTD VHFLKEGCGD DNVCNSNLKL EYKFGTREGN
     QDKFSYLPIQ KGIPELVLKD QKDIALEITV TNSPSDPRNP RKDGDDAHEA KLIATFPDTL
     TYSAYRELRA FPEKQLSCVA NQNGSQADCE LGNPFKRNSS VTFYLILSTT EVTFDTTDLD
     INLKLETTSN QDNLAPITAK AKVVIELLLS VSGVAKPSQV YFGGTVVGEQ AMKSEDEVGS
     LIEYEFRVIN LGKPLKNLGT ATLNIQWPKE ISNGKWLLYL MKVESKGLEQ IVCEPHNEIN
     YLKLKESHNS RKKRDLPEKQ IDDSRKFSLF PERKYQTLNC SVNVRCVNIR CPLRGLDSKA
     SLVLRSRLWN STFLEEYSKL NYLDILLRAS IDVTAAAQNI KLPHAGTQVR VTVFPSKTVA
     QYSGVAWWII LLAVLAGILM LALLVFLLWK VQRFSPVSSR REHGSIQAGL VQEELRIVHL
     VLKV
//