ID Q3TWK2_MOUSE Unreviewed; 784 AA. AC Q3TWK2; DT 11-OCT-2005, integrated into UniProtKB/TrEMBL. DT 11-OCT-2005, sequence version 1. DT 09-FEB-2010, entry version 40. DE SubName: Full=Putative uncharacterized protein; DE Flags: Fragment; GN Name=Itga6; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6J; RX PubMed=16141072; DOI=10.1126/science.1112014; RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E., RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., RA Hayashizaki Y.; RT "The transcriptional landscape of the mammalian genome."; RL Science 309:1559-1563(2005). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein (By similarity). CC -!- SIMILARITY: Belongs to the integrin alpha chain family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK159653; BAE35264.1; -; mRNA. DR IPI; IPI00331413; -. DR UniGene; Mm.225096; -. DR SMR; Q3TWK2; 16-178, 721-755. DR STRING; Q3TWK2; -. DR Ensembl; ENSMUST00000028522; ENSMUSP00000028522; ENSMUSG00000027111; Mus musculus. DR Ensembl; ENSMUST00000036783; ENSMUSP00000040155; ENSMUSG00000027111; Mus musculus. DR Ensembl; ENSMUST00000112101; ENSMUSP00000107729; ENSMUSG00000027111; Mus musculus. DR UCSC; uc008kbe.1; mouse. DR MGI; MGI:96605; Itga6. DR HOVERGEN; Q3TWK2; -. DR InParanoid; Q3TWK2; -. DR ArrayExpress; Q3TWK2; -. DR Bgee; Q3TWK2; -. DR Genevestigator; Q3TWK2; -. DR GO; GO:0016323; C:basolateral plasma membrane; IDA:MGI. DR GO; GO:0005913; C:cell-cell adherens junction; IEA:Compara. DR GO; GO:0009897; C:external side of plasma membrane; IDA:MGI. DR GO; GO:0008305; C:integrin complex; IDA:MGI. DR GO; GO:0005178; F:integrin binding; IPI:MGI. DR GO; GO:0043236; F:laminin binding; IEA:Compara. DR GO; GO:0004872; F:receptor activity; IEA:UniProtKB-KW. DR GO; GO:0050873; P:brown fat cell differentiation; IDA:MGI. DR GO; GO:0033627; P:cell adhesion mediated by integrin; IDA:MGI. DR GO; GO:0007160; P:cell-matrix adhesion; IMP:MGI. DR GO; GO:0031668; P:cellular response to extracellular stimulus; IDA:MGI. DR GO; GO:0046847; P:filopodium assembly; IMP:MGI. DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW. DR GO; GO:0050900; P:leukocyte migration; IGI:MGI. DR GO; GO:0050900; P:leukocyte migration; IMP:MGI. DR GO; GO:0042475; P:odontogenesis of dentine-containing tooth; IMP:MGI. DR GO; GO:0022409; P:positive regulation of cell-cell adhesion; IDA:MGI. DR InterPro; IPR013519; Int_alpha_beta-p. DR InterPro; IPR000413; Integrin_alpha. DR InterPro; IPR013649; Integrin_alpha-2. DR Pfam; PF08441; Integrin_alpha2; 1. DR PRINTS; PR01185; INTEGRINA. DR SMART; SM00191; Int_alpha; 3. PE 2: Evidence at transcript level; KW Cell adhesion; Integrin; Membrane; Receptor; Transmembrane. FT NON_TER 1 1 SQ SEQUENCE 784 AA; 87609 MW; 7F14151D22EA192C CRC64; VVLLKRDMKS AHLLPEYIFD GEGLASSFGY DVAVVDLNAD GWQDIVIGAP QYFDRDGEVG GAVYVYINQQ GKWSNVKPIR LNGTKDSMFG ISVKNIGDIN QDGYPDIAVG APYDDLGKVF IYHGSPTGII TKPTQVLEGT SPYFGYSIAG NMDLDRNSYP DLAVGSLSDS VTIFRSRPVI NILKTITVTP NRIDLRQKSM CGSPSGICLK VKACFEYTAK PSGYNPPISI LGILEAEKER RKSGLSSRVQ FRNQGSEPKY TQELTLNRQK QRACMEETLW LQENIRDKLR PIPITASVEI QEPSSRRRVN SLPEVLPILN SNEAKTVQTD VHFLKEGCGD DNVCNSNLKL EYKFGTREGN QDKFSYLPIQ KGIPELVLKD QKDIALEITV TNSPSDPRNP RKDGDDAHEA KLIATFPDTL TYSAYRELRA FPEKQLSCVA NQNGSQADCE LGNPFKRNSS VTFYLILSTT EVTFDTTDLD INLKLETTSN QDNLAPITAK AKVVIELLLS VSGVAKPSQV YFGGTVVGEQ AMKSEDEVGS LIEYEFRVIN LGKPLKNLGT ATLNIQWPKE ISNGKWLLYL MKVESKGLEQ IVCEPHNEIN YLKLKESHNS RKKRDLPEKQ IDDSRKFSLF PERKYQTLNC SVNVRCVNIR CPLRGLDSKA SLVLRSRLWN STFLEEYSKL NYLDILLRAS IDVTAAAQNI KLPHAGTQVR VTVFPSKTVA QYSGVAWWII LLAVLAGILM LALLVFLLWK VQRFSPVSSR REHGSIQAGL VQEELRIVHL VLKV //