ID Q3TVS1_MOUSE Unreviewed; 582 AA. AC Q3TVS1; DT 11-OCT-2005, integrated into UniProtKB/TrEMBL. DT 11-OCT-2005, sequence version 1. DT 04-MAR-2015, entry version 81. DE SubName: Full=Putative uncharacterized protein {ECO:0000313|EMBL:BAE35547.1}; GN Name=App {ECO:0000313|MGI:MGI:88059}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAE35547.1}; RN [1] {ECO:0000313|EMBL:BAE35547.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE35547.1}; RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9; RA Carninci P., Hayashizaki Y.; RT "High-efficiency full-length cDNA cloning."; RL Methods Enzymol. 303:19-44(1999). RN [2] {ECO:0000313|EMBL:BAE35547.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE35547.1}; RX PubMed=11042159; DOI=10.1101/gr.145100; RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.; RT "Normalization and subtraction of cap-trapper-selected cDNAs to RT prepare full-length cDNA libraries for rapid discovery of new genes."; RL Genome Res. 10:1617-1630(2000). RN [3] {ECO:0000313|EMBL:BAE35547.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE35547.1}; RX PubMed=11076861; DOI=10.1101/gr.152600; RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., RA Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., RA Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., RA Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., RA Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., RA Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.; RT "RIKEN integrated sequence analysis (RISA) system--384-format RT sequencing pipeline with 384 multicapillary sequencer."; RL Genome Res. 10:1757-1771(2000). RN [4] {ECO:0000313|EMBL:BAE35547.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE35547.1}; RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium; RT "Functional annotation of a full-length mouse cDNA collection."; RL Nature 409:685-690(2001). RN [5] {ECO:0000313|EMBL:BAE35547.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE35547.1}; RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). RN [6] {ECO:0000313|EMBL:BAE35547.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE35547.1}; RA Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., RA Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., RA Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., RA Nishiyori H., Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., RA Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., RA Muramatsu M., Hayashizaki Y.; RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:BAE35547.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE35547.1}; RG The FANTOM Consortium; RG Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group); RT "The Transcriptional Landscape of the Mammalian Genome."; RL Science 309:1559-1563(2005). RN [8] {ECO:0000313|EMBL:BAE35547.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE35547.1}; RX PubMed=16141073; DOI=10.1126/science.1112009; RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium; RT "Antisense Transcription in the Mammalian Transcriptome."; RL Science 309:1564-1566(2005). CC -!- SIMILARITY: Contains 1 BPTI/Kunitz inhibitor domain. CC {ECO:0000256|RuleBase:RU000413}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK159999; BAE35547.1; -; mRNA. DR ProteinModelPortal; Q3TVS1; -. DR SMR; Q3TVS1; 28-189, 287-342, 374-562. DR PRIDE; Q3TVS1; -. DR MGI; MGI:88059; App. DR HOVERGEN; HBG000051; -. DR ChiTaRS; App; mouse. DR Genevestigator; Q3TVS1; -. DR GO; GO:0045177; C:apical part of cell; IDA:MGI. DR GO; GO:0030424; C:axon; IDA:MGI. DR GO; GO:0009986; C:cell surface; ISO:MGI. DR GO; GO:0005911; C:cell-cell junction; IDA:MGI. DR GO; GO:0035253; C:ciliary rootlet; IDA:MGI. DR GO; GO:0005737; C:cytoplasm; IDA:MGI. DR GO; GO:0031410; C:cytoplasmic vesicle; IDA:MGI. DR GO; GO:0005768; C:endosome; ISO:MGI. DR GO; GO:0030134; C:ER to Golgi transport vesicle; IDA:MGI. DR GO; GO:0005615; C:extracellular space; ISO:MGI. DR GO; GO:0070062; C:extracellular vesicular exosome; ISO:MGI. DR GO; GO:0005794; C:Golgi apparatus; IDA:MGI. DR GO; GO:0016021; C:integral component of membrane; IDA:MGI. DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI. DR GO; GO:0016020; C:membrane; IDA:MGI. DR GO; GO:0045121; C:membrane raft; ISO:MGI. DR GO; GO:0031594; C:neuromuscular junction; IDA:MGI. DR GO; GO:0043005; C:neuron projection; IDA:MGI. DR GO; GO:0005641; C:nuclear envelope lumen; ISO:MGI. DR GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:MGI. DR GO; GO:0005886; C:plasma membrane; IDA:MGI. DR GO; GO:0043235; C:receptor complex; ISO:MGI. DR GO; GO:0051233; C:spindle midzone; IDA:MGI. DR GO; GO:0033130; F:acetylcholine receptor binding; ISO:MGI. DR GO; GO:0003677; F:DNA binding; IDA:MGI. DR GO; GO:0019899; F:enzyme binding; ISO:MGI. DR GO; GO:0008201; F:heparin binding; IEA:InterPro. DR GO; GO:0042802; F:identical protein binding; ISO:MGI. DR GO; GO:0051425; F:PTB domain binding; ISO:MGI. DR GO; GO:0005102; F:receptor binding; ISO:MGI. DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; ISO:MGI. DR GO; GO:0046914; F:transition metal ion binding; IEA:InterPro. DR GO; GO:0008344; P:adult locomotory behavior; IMP:MGI. DR GO; GO:0008088; P:axon cargo transport; IMP:MGI. DR GO; GO:0016199; P:axon midline choice point recognition; IMP:MGI. DR GO; GO:0007409; P:axonogenesis; IMP:MGI. DR GO; GO:0006878; P:cellular copper ion homeostasis; IMP:MGI. DR GO; GO:0008203; P:cholesterol metabolic process; IMP:MGI. DR GO; GO:0048669; P:collateral sprouting in absence of injury; IGI:MGI. DR GO; GO:0016358; P:dendrite development; IMP:MGI. DR GO; GO:0006897; P:endocytosis; IMP:MGI. DR GO; GO:0030198; P:extracellular matrix organization; IGI:MGI. DR GO; GO:0030900; P:forebrain development; IMP:MGI. DR GO; GO:0035235; P:ionotropic glutamate receptor signaling pathway; IMP:MGI. DR GO; GO:0007626; P:locomotory behavior; IGI:MGI. DR GO; GO:0007617; P:mating behavior; IGI:MGI. DR GO; GO:0006378; P:mRNA polyadenylation; IDA:MGI. DR GO; GO:0010951; P:negative regulation of endopeptidase activity; ISO:MGI. DR GO; GO:0045665; P:negative regulation of neuron differentiation; IDA:MGI. DR GO; GO:0050885; P:neuromuscular process controlling balance; IGI:MGI. DR GO; GO:0051402; P:neuron apoptotic process; IGI:MGI. DR GO; GO:0031175; P:neuron projection development; IDA:MGI. DR GO; GO:0016322; P:neuron remodeling; IMP:MGI. DR GO; GO:0010971; P:positive regulation of G2/M transition of mitotic cell cycle; IMP:MGI. DR GO; GO:0045931; P:positive regulation of mitotic cell cycle; IMP:MGI. DR GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI. DR GO; GO:0051260; P:protein homooligomerization; ISO:MGI. DR GO; GO:0006468; P:protein phosphorylation; IMP:MGI. DR GO; GO:0007176; P:regulation of epidermal growth factor-activated receptor activity; IGI:MGI. DR GO; GO:0010468; P:regulation of gene expression; IDA:MGI. DR GO; GO:0040014; P:regulation of multicellular organism growth; IMP:MGI. DR GO; GO:0043393; P:regulation of protein binding; IMP:MGI. DR GO; GO:0050803; P:regulation of synapse structure or activity; IMP:MGI. DR GO; GO:0006417; P:regulation of translation; IDA:MGI. DR GO; GO:0006979; P:response to oxidative stress; IGI:MGI. DR GO; GO:0051563; P:smooth endoplasmic reticulum calcium ion homeostasis; IGI:MGI. DR GO; GO:0001967; P:suckling behavior; IGI:MGI. DR GO; GO:0051124; P:synaptic growth at neuromuscular junction; IGI:MGI. DR GO; GO:0008542; P:visual learning; IMP:MGI. DR Gene3D; 3.30.1490.140; -; 1. DR Gene3D; 3.90.570.10; -; 1. DR Gene3D; 4.10.410.10; -; 1. DR InterPro; IPR008155; Amyloid_glyco. DR InterPro; IPR011178; Amyloid_glyco_Cu-bd. DR InterPro; IPR024329; Amyloid_glyco_E2_domain. DR InterPro; IPR008154; Amyloid_glyco_extra. DR InterPro; IPR019744; Amyloid_glyco_extracell_CS. DR InterPro; IPR015849; Amyloid_glyco_heparin-bd. DR InterPro; IPR028866; APP. DR InterPro; IPR002223; Prot_inh_Kunz-m. DR InterPro; IPR020901; Prtase_inh_Kunz-CS. DR PANTHER; PTHR23103:SF7; PTHR23103:SF7; 1. DR Pfam; PF12924; APP_Cu_bd; 1. DR Pfam; PF12925; APP_E2; 1. DR Pfam; PF02177; APP_N; 1. DR Pfam; PF00014; Kunitz_BPTI; 1. DR PRINTS; PR00203; AMYLOIDA4. DR PRINTS; PR00759; BASICPTASE. DR SMART; SM00006; A4_EXTRA; 1. DR SMART; SM00131; KU; 1. DR SUPFAM; SSF109843; SSF109843; 1. DR SUPFAM; SSF56491; SSF56491; 1. DR SUPFAM; SSF57362; SSF57362; 1. DR SUPFAM; SSF89811; SSF89811; 1. DR PROSITE; PS00319; A4_EXTRA; 1. DR PROSITE; PS00280; BPTI_KUNITZ_1; 1. DR PROSITE; PS50279; BPTI_KUNITZ_2; 1. PE 2: Evidence at transcript level; SQ SEQUENCE 582 AA; 65952 MW; 61351D75CA2C4D6E CRC64; MLPSLALLLL AAWTVRALEV PTDGNAGLLA EPQIAMFCGK LNMHMNVQNG KWESDPSGTK TCVGTKEGIL QYCQEVYPEL QITNVVEANQ PVTIQNWCKR GRKQCKTHTH IVIPYRCLVG EFVSDALLVP DKCKFLHQER MDVCETHLHW HTVAKETCSE KSTNLHDYGM LLPCGIDKFR GVEFVCCPLA EESDSVDSAD AEEDDSDVWW GGADTDYADG GEDKVVEVAE EEEVADVEEE EADDDEDVED GDEVEEEAEE PYEEATERTT STATTTTTTT ESVEEVVREV CSEQAETGPC RAMISRWYFD VTEGKCVPFF YGGCGGNRNN FDTEEYCMAV CGSVSTQSLL KTTSEPLPQD PDKLPTTAAS TPDAVDKYLE TPGDENEHAH FQKAKERLEA KHRERMSQVM REWEEAERQA KNLPKADKKA VIQHFQEKVE SLEQEAANER QQLVETHMAR VEAMLNDRRR LALENYITAL QAVPPRPHHV FNMLKKYVRA EQKDRQHTLK HFEHVRMVDP KKAAQIRSQV MTHLRVIYER MNQSLSLLYN VPAVAEEIQD EVGRRRRDPR GAPSLQDAAE RI //