ID Q3TVS1_MOUSE Unreviewed; 582 AA. AC Q3TVS1; DT 11-OCT-2005, integrated into UniProtKB/TrEMBL. DT 11-OCT-2005, sequence version 1. DT 10-JUN-2008, entry version 25. DE Osteoclast-like cell cDNA, RIKEN full-length enriched library, DE clone:I420043F20 product:amyloid beta (A4) protein, full insert DE sequence. GN Name=App; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6J; RX PubMed=16141072; DOI=10.1126/science.1112014; RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E., RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., RA Hayashizaki Y.; RT "The transcriptional landscape of the mammalian genome."; RL Science 309:1559-1563(2005). CC -!- SIMILARITY: Contains 1 BPTI/Kunitz inhibitor domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK159999; BAE35547.1; -; mRNA. DR UniGene; Mm.277585; -. DR UniGene; Mm.456333; -. DR SMR; Q3TVS1; 28-123, 126-189, 287-342, 460-562. DR Ensembl; ENSMUSG00000022892; Mus musculus. DR MGI; MGI:88059; App. DR HOVERGEN; Q3TVS1; -. DR ArrayExpress; Q3TVS1; -. DR GO; GO:0045177; C:apical part of cell; IDA:MGI. DR GO; GO:0030424; C:axon; IDA:MGI. DR GO; GO:0035253; C:ciliary rootlet; IDA:MGI. DR GO; GO:0031410; C:cytoplasmic vesicle; IDA:MGI. DR GO; GO:0005794; C:Golgi apparatus; IDA:MGI. DR GO; GO:0016021; C:integral to membrane; IDA:MGI. DR GO; GO:0005624; C:membrane fraction; IDA:MGI. DR GO; GO:0031594; C:neuromuscular junction; IDA:MGI. DR GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:MGI. DR GO; GO:0051233; C:spindle midzone; IDA:MGI. DR GO; GO:0003677; F:DNA binding; IDA:MGI. DR GO; GO:0008344; P:adult locomotory behavior; IMP:MGI. DR GO; GO:0008088; P:axon cargo transport; IMP:MGI. DR GO; GO:0016199; P:axon midline choice point recognition; IMP:MGI. DR GO; GO:0006878; P:cellular copper ion homeostasis; IGI:MGI. DR GO; GO:0006878; P:cellular copper ion homeostasis; IMP:MGI. DR GO; GO:0048669; P:collateral sprouting in the absence of injury; IGI:MGI. DR GO; GO:0016358; P:dendrite development; IGI:MGI. DR GO; GO:0016358; P:dendrite development; IMP:MGI. DR GO; GO:0006897; P:endocytosis; IMP:MGI. DR GO; GO:0030198; P:extracellular matrix organization and bioge...; IGI:MGI. DR GO; GO:0030900; P:forebrain development; IMP:MGI. DR GO; GO:0000085; P:G2 phase of mitotic cell cycle; IMP:MGI. DR GO; GO:0035235; P:ionotropic glutamate receptor signaling pat...; IMP:MGI. DR GO; GO:0007617; P:mating behavior; IGI:MGI. DR GO; GO:0006378; P:mRNA polyadenylation; IDA:MGI. DR GO; GO:0050885; P:neuromuscular process controlling balance; IGI:MGI. DR GO; GO:0016322; P:neuron remodeling; IMP:MGI. DR GO; GO:0045931; P:positive regulation of mitotic cell cycle; IMP:MGI. DR GO; GO:0045944; P:positive regulation of transcription from R...; IDA:MGI. DR GO; GO:0006468; P:protein amino acid phosphorylation; IMP:MGI. DR GO; GO:0007176; P:regulation of epidermal growth factor recep...; IGI:MGI. DR GO; GO:0040014; P:regulation of multicellular organism growth; IMP:MGI. DR GO; GO:0050803; P:regulation of synapse structure and activity; IMP:MGI. DR GO; GO:0006417; P:regulation of translation; IDA:MGI. DR GO; GO:0051563; P:smooth endoplasmic reticulum calcium ion ho...; IGI:MGI. DR GO; GO:0001967; P:suckling behavior; IGI:MGI. DR GO; GO:0051124; P:synaptic growth at neuromuscular junction; IGI:MGI. DR GO; GO:0008542; P:visual learning; IMP:MGI. DR InterPro; IPR008155; Amyloid_glyco_core. DR InterPro; IPR011178; Amyloid_glyco_Cu-bd. DR InterPro; IPR008154; Amyloid_glyco_extra. DR InterPro; IPR015849; Amyloid_glyco_heparin-bd. DR InterPro; IPR002223; Prot_inh_Kunz-m. DR Gene3D; G3DSA:3.30.1490.140; Amyloid_glyco_Cu-bd; 1. DR Gene3D; G3DSA:3.90.570.10; Amyloid_glyco_heparin-bd; 1. DR Gene3D; G3DSA:4.10.410.10; Prot_inh_Kunz-m; 1. DR Pfam; PF02177; A4_EXTRA; 1. DR Pfam; PF00014; Kunitz_BPTI; 1. DR PRINTS; PR00203; AMYLOIDA4. DR PRINTS; PR00759; BASICPTASE. DR ProDom; PD000222; Prot_Inh_Kunz-m; 1. DR SMART; SM00006; A4_EXTRA; 1. DR SMART; SM00131; KU; 1. DR PROSITE; PS00319; A4_EXTRA; 1. DR PROSITE; PS00280; BPTI_KUNITZ_1; 1. DR PROSITE; PS50279; BPTI_KUNITZ_2; 1. PE 2: Evidence at transcript level; SQ SEQUENCE 582 AA; 65952 MW; 61351D75CA2C4D6E CRC64; MLPSLALLLL AAWTVRALEV PTDGNAGLLA EPQIAMFCGK LNMHMNVQNG KWESDPSGTK TCVGTKEGIL QYCQEVYPEL QITNVVEANQ PVTIQNWCKR GRKQCKTHTH IVIPYRCLVG EFVSDALLVP DKCKFLHQER MDVCETHLHW HTVAKETCSE KSTNLHDYGM LLPCGIDKFR GVEFVCCPLA EESDSVDSAD AEEDDSDVWW GGADTDYADG GEDKVVEVAE EEEVADVEEE EADDDEDVED GDEVEEEAEE PYEEATERTT STATTTTTTT ESVEEVVREV CSEQAETGPC RAMISRWYFD VTEGKCVPFF YGGCGGNRNN FDTEEYCMAV CGSVSTQSLL KTTSEPLPQD PDKLPTTAAS TPDAVDKYLE TPGDENEHAH FQKAKERLEA KHRERMSQVM REWEEAERQA KNLPKADKKA VIQHFQEKVE SLEQEAANER QQLVETHMAR VEAMLNDRRR LALENYITAL QAVPPRPHHV FNMLKKYVRA EQKDRQHTLK HFEHVRMVDP KKAAQIRSQV MTHLRVIYER MNQSLSLLYN VPAVAEEIQD EVGRRRRDPR GAPSLQDAAE RI //