ID Q3TUM2_MOUSE Unreviewed; 186 AA. AC Q3TUM2; DT 11-OCT-2005, integrated into UniProtKB/TrEMBL. DT 11-OCT-2005, sequence version 1. DT 24-JAN-2024, entry version 146. DE RecName: Full=ADP-ribosylation factor-like protein 6 {ECO:0000256|ARBA:ARBA00019766}; GN Name=Arl6 {ECO:0000313|MGI:MGI:1927136}; GN Synonyms=ARL6 {ECO:0000313|EMBL:BAE79900.1}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAE35949.1}; RN [1] {ECO:0000313|EMBL:BAE35949.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE35949.1}; RC TISSUE=Hippocampus {ECO:0000313|EMBL:BAE35949.1}; RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9; RA Carninci P., Hayashizaki Y.; RT "High-efficiency full-length cDNA cloning."; RL Methods Enzymol. 303:19-44(1999). RN [2] {ECO:0000313|EMBL:BAE35949.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE35949.1}; RC TISSUE=Hippocampus {ECO:0000313|EMBL:BAE35949.1}; RX PubMed=11042159; DOI=10.1101/gr.145100; RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.; RT "Normalization and subtraction of cap-trapper-selected cDNAs to prepare RT full-length cDNA libraries for rapid discovery of new genes."; RL Genome Res. 10:1617-1630(2000). RN [3] {ECO:0000313|EMBL:BAE35949.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE35949.1}; RC TISSUE=Hippocampus {ECO:0000313|EMBL:BAE35949.1}; RX PubMed=11076861; DOI=10.1101/gr.152600; RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., RA Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R., RA Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., RA Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., RA Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., RA Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.; RT "RIKEN integrated sequence analysis (RISA) system--384-format sequencing RT pipeline with 384 multicapillary sequencer."; RL Genome Res. 10:1757-1771(2000). RN [4] {ECO:0000313|EMBL:BAE35949.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE35949.1}; RC TISSUE=Hippocampus {ECO:0000313|EMBL:BAE35949.1}; RX PubMed=11217851; DOI=10.1038/35055500; RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium; RT "Functional annotation of a full-length mouse cDNA collection."; RL Nature 409:685-690(2001). RN [5] {ECO:0000313|EMBL:BAE35949.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE35949.1}; RC TISSUE=Hippocampus {ECO:0000313|EMBL:BAE35949.1}; RX PubMed=12466851; DOI=10.1038/nature01266; RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). RN [6] {ECO:0000313|EMBL:BAE35949.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE35949.1}; RC TISSUE=Hippocampus {ECO:0000313|EMBL:BAE35949.1}; RA Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., RA Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., RA Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H., Nomura K., RA Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., RA Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.; RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:BAE79900.1} RP NUCLEOTIDE SEQUENCE. RA Takada T., Iida K., Sasaki H., Taira M., Kimura H.; RT "ADP-ribosylation factor-like protein 6 (ARL6)."; RL Int. J. Dev. Biol. 0:0-0(2005). RN [8] {ECO:0000313|EMBL:BAE35949.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE35949.1}; RC TISSUE=Hippocampus {ECO:0000313|EMBL:BAE35949.1}; RG The FANTOM Consortium; RG Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group); RT "The Transcriptional Landscape of the Mammalian Genome."; RL Science 309:1559-1563(2005). RN [9] {ECO:0000313|EMBL:BAE35949.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE35949.1}; RC TISSUE=Hippocampus {ECO:0000313|EMBL:BAE35949.1}; RX PubMed=16141073; DOI=10.1126/science.1112009; RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium; RT "Antisense Transcription in the Mammalian Transcriptome."; RL Science 309:1564-1566(2005). CC -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane CC {ECO:0000256|ARBA:ARBA00004522}; Peripheral membrane protein CC {ECO:0000256|ARBA:ARBA00004522}; Cytoplasmic side CC {ECO:0000256|ARBA:ARBA00004522}. CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family. CC {ECO:0000256|RuleBase:RU003925}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK160666; BAE35949.1; -; mRNA. DR EMBL; AB232697; BAE79900.1; -; mRNA. DR RefSeq; NP_062639.3; NM_019665.3. DR AlphaFoldDB; Q3TUM2; -. DR SMR; Q3TUM2; -. DR SwissPalm; Q3TUM2; -. DR MaxQB; Q3TUM2; -. DR Antibodypedia; 15743; 167 antibodies from 30 providers. DR DNASU; 56297; -. DR GeneID; 56297; -. DR KEGG; mmu:56297; -. DR AGR; MGI:1927136; -. DR CTD; 84100; -. DR MGI; MGI:1927136; Arl6. DR VEuPathDB; HostDB:ENSMUSG00000022722; -. DR OMA; WQIVPSN; -. DR OrthoDB; 5349301at2759; -. DR BioGRID-ORCS; 56297; 3 hits in 77 CRISPR screens. DR ChiTaRS; Arl6; mouse. DR ExpressionAtlas; Q3TUM2; baseline and differential. DR GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW. DR GO; GO:0003924; F:GTPase activity; IEA:InterPro. DR CDD; cd04157; Arl6; 1. DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1. DR InterPro; IPR041839; Arl6. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR005225; Small_GTP-bd_dom. DR InterPro; IPR024156; Small_GTPase_ARF. DR InterPro; IPR006689; Small_GTPase_ARF/SAR. DR NCBIfam; TIGR00231; small_GTP; 1. DR PANTHER; PTHR11711; ADP RIBOSYLATION FACTOR-RELATED; 1. DR PANTHER; PTHR11711:SF21; ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 6; 1. DR Pfam; PF00025; Arf; 1. DR PRINTS; PR00328; SAR1GTPBP. DR SMART; SM00177; ARF; 1. DR SMART; SM00178; SAR; 1. DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1. DR PROSITE; PS51417; ARF; 1. PE 2: Evidence at transcript level; KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490}; KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU003925}; KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, KW ECO:0000256|RuleBase:RU003925}. SQ SEQUENCE 186 AA; 20959 MW; 4F26947318977386 CRC64; MGLLDRLSGL LGLKKKEVHV LCLGLDNSGK TTIINKLKPS NAQSQDIVPT IGFSIEKFKS SSLSFTVFDM SGQGRYRNLW EHYYKDGQAI IFVIDSSDKL RMVVAKEELD TLLNHPDIKH RRIPILFFAN KMDLRDSVTS VKVSQLLCLE SIKDKPWHIC ASDAIKGEGL QEGVDWLQDQ IQAVKT //