ID Q3T9H2_MOUSE Unreviewed; 705 AA. AC Q3T9H2; DT 11-OCT-2005, integrated into UniProtKB/TrEMBL. DT 11-OCT-2005, sequence version 1. DT 02-JUN-2021, entry version 75. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:BAE43048.1}; DE Flags: Fragment; GN Name=Adar {ECO:0000313|MGI:MGI:1889575}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAE43048.1}; RN [1] {ECO:0000313|EMBL:BAE43048.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=NOD {ECO:0000313|EMBL:BAE43048.1}; RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE43048.1}; RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9; RA Carninci P., Hayashizaki Y.; RT "High-efficiency full-length cDNA cloning."; RL Methods Enzymol. 303:19-44(1999). RN [2] {ECO:0000313|EMBL:BAE43048.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=NOD {ECO:0000313|EMBL:BAE43048.1}; RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE43048.1}; RX PubMed=11042159; DOI=10.1101/gr.145100; RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.; RT "Normalization and subtraction of cap-trapper-selected cDNAs to prepare RT full-length cDNA libraries for rapid discovery of new genes."; RL Genome Res. 10:1617-1630(2000). RN [3] {ECO:0000313|EMBL:BAE43048.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=NOD {ECO:0000313|EMBL:BAE43048.1}; RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE43048.1}; RX PubMed=11076861; DOI=10.1101/gr.152600; RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., RA Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R., RA Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., RA Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., RA Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., RA Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.; RT "RIKEN integrated sequence analysis (RISA) system--384-format sequencing RT pipeline with 384 multicapillary sequencer."; RL Genome Res. 10:1757-1771(2000). RN [4] {ECO:0000313|EMBL:BAE43048.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=NOD {ECO:0000313|EMBL:BAE43048.1}; RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE43048.1}; RX PubMed=11217851; DOI=10.1038/35055500; RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium; RT "Functional annotation of a full-length mouse cDNA collection."; RL Nature 409:685-690(2001). RN [5] {ECO:0000313|EMBL:BAE43048.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=NOD {ECO:0000313|EMBL:BAE43048.1}; RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE43048.1}; RX PubMed=12466851; DOI=10.1038/nature01266; RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). RN [6] {ECO:0000313|EMBL:BAE43048.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=NOD {ECO:0000313|EMBL:BAE43048.1}; RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE43048.1}; RA Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., RA Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., RA Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H., Nomura K., RA Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., RA Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.; RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:BAE43048.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=NOD {ECO:0000313|EMBL:BAE43048.1}; RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE43048.1}; RG The FANTOM Consortium; RG Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group); RT "The Transcriptional Landscape of the Mammalian Genome."; RL Science 309:1559-1563(2005). RN [8] {ECO:0000313|EMBL:BAE43048.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=NOD {ECO:0000313|EMBL:BAE43048.1}; RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE43048.1}; RX PubMed=16141073; DOI=10.1126/science.1112009; RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium; RT "Antisense Transcription in the Mammalian Transcriptome."; RL Science 309:1564-1566(2005). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK172523; BAE43048.1; -; mRNA. DR PeptideAtlas; Q3T9H2; -. DR MGI; MGI:1889575; Adar. DR ChiTaRS; Adar; mouse. DR GO; GO:0004000; F:adenosine deaminase activity; IEA:InterPro. DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule. DR GO; GO:0006396; P:RNA processing; IEA:InterPro. DR CDD; cd19913; DSRM_DRADA_rpt1; 1. DR CDD; cd19915; DSRM_DRADA_rpt3; 1. DR InterPro; IPR002466; A_deamin. DR InterPro; IPR044456; ADAR1_DSRM_1. DR InterPro; IPR044457; ADAR1_DSRM_3. DR InterPro; IPR014720; dsRBD_dom. DR Pfam; PF02137; A_deamin; 1. DR Pfam; PF00035; dsrm; 3. DR SMART; SM00552; ADEAMc; 1. DR SMART; SM00358; DSRM; 3. DR PROSITE; PS50141; A_DEAMIN_EDITASE; 1. DR PROSITE; PS50137; DS_RBD; 3. PE 2: Evidence at transcript level; KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266}. FT DOMAIN 9..77 FT /note="DRBM" FT /evidence="ECO:0000259|PROSITE:PS50137" FT DOMAIN 120..188 FT /note="DRBM" FT /evidence="ECO:0000259|PROSITE:PS50137" FT DOMAIN 228..296 FT /note="DRBM" FT /evidence="ECO:0000259|PROSITE:PS50137" FT DOMAIN 362..697 FT /note="A to I editase" FT /evidence="ECO:0000259|PROSITE:PS50141" FT REGION 80..117 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 184..210 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 81..103 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 191..209 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:BAE43048.1" SQ SEQUENCE 705 AA; 77885 MW; 5B4268FC5FE96A37 CRC64; KLTECQLKNP VSGLLEYAQF TSQTCDFNLI EQSGPSHEPR FKFQVVINGR EFPPAEAGSK KVAKQDAAVK AMAILLREAK AKDSGQPEDL SHCPMEEDSE KPAEAQAPSS SATSLFSGKS PVTTLLECMH KLGNSCEFRL LSKEGPAHDP KFQYCVAVGA QTFPPVSAPS KKVAKQMAAE EAMKALQEEA ASSADDQSGG ANTDSLDESM APNKIRRIGE LVRYLNTNPV GGLLEYARSH GFAAEFKLID QSGPPHEPKF VYQAKVGGRW FPAVCAHSKK QGKQDAADAA LRVLIGESEK AEQLGFAELP LSGSTFHDQI AMLSHRCFNA LTNSFQPSLL GRKILAAIIM KRDPEDMGVV VSLGTGNRCV KGDSLSLKGE TVNDCHAEII SRRGFIRFLY SELMKYNNHT AKNSIFELAR GGEKLQIKKT VSFHLYISTA PCGDGALFDK SCSDRAVEST ESRHYPVFEN PKQGKLRTKV ENGEGTIPVE SSDIVPTWDG IRLGERLRTM SCSDKILRWN VLGLQGALLT HFLQPVYLKS VTLGYLFSQG HLTRAICCRV TRDGKAFEDG LRYPFIVNHP KVGRVSVYDS KRQSGKTKET SVNWCMADGY DLEILDGTRG TVDGPGKELS RVSKKNIFLQ FKKLCSFRAR RDLLQLSYGE AKKAARDYDL AKNYFKKSLR DMGYGNWISK PQEEKNFYLC PVPND //