ID Q3T9H2_MOUSE Unreviewed; 705 AA. AC Q3T9H2; DT 11-OCT-2005, integrated into UniProtKB/TrEMBL. DT 11-OCT-2005, sequence version 1. DT 16-SEP-2015, entry version 55. DE SubName: Full=Putative uncharacterized protein {ECO:0000313|EMBL:BAE43048.1}; DE Flags: Fragment; GN Name=Adar {ECO:0000313|MGI:MGI:1889575}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAE43048.1}; RN [1] {ECO:0000313|EMBL:BAE43048.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=NOD {ECO:0000313|EMBL:BAE43048.1}; RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE43048.1}; RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9; RA Carninci P., Hayashizaki Y.; RT "High-efficiency full-length cDNA cloning."; RL Methods Enzymol. 303:19-44(1999). RN [2] {ECO:0000313|EMBL:BAE43048.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=NOD {ECO:0000313|EMBL:BAE43048.1}; RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE43048.1}; RX PubMed=11042159; DOI=10.1101/gr.145100; RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.; RT "Normalization and subtraction of cap-trapper-selected cDNAs to RT prepare full-length cDNA libraries for rapid discovery of new genes."; RL Genome Res. 10:1617-1630(2000). RN [3] {ECO:0000313|EMBL:BAE43048.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=NOD {ECO:0000313|EMBL:BAE43048.1}; RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE43048.1}; RX PubMed=11076861; DOI=10.1101/gr.152600; RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., RA Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., RA Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., RA Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., RA Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., RA Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.; RT "RIKEN integrated sequence analysis (RISA) system--384-format RT sequencing pipeline with 384 multicapillary sequencer."; RL Genome Res. 10:1757-1771(2000). RN [4] {ECO:0000313|EMBL:BAE43048.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=NOD {ECO:0000313|EMBL:BAE43048.1}; RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE43048.1}; RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium; RT "Functional annotation of a full-length mouse cDNA collection."; RL Nature 409:685-690(2001). RN [5] {ECO:0000313|EMBL:BAE43048.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=NOD {ECO:0000313|EMBL:BAE43048.1}; RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE43048.1}; RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). RN [6] {ECO:0000313|EMBL:BAE43048.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=NOD {ECO:0000313|EMBL:BAE43048.1}; RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE43048.1}; RA Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., RA Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., RA Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., RA Nishiyori H., Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., RA Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., RA Muramatsu M., Hayashizaki Y.; RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:BAE43048.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=NOD {ECO:0000313|EMBL:BAE43048.1}; RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE43048.1}; RG The FANTOM Consortium; RG Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group); RT "The Transcriptional Landscape of the Mammalian Genome."; RL Science 309:1559-1563(2005). RN [8] {ECO:0000313|EMBL:BAE43048.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=NOD {ECO:0000313|EMBL:BAE43048.1}; RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE43048.1}; RX PubMed=16141073; DOI=10.1126/science.1112009; RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium; RT "Antisense Transcription in the Mammalian Transcriptome."; RL Science 309:1564-1566(2005). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK172523; BAE43048.1; -; mRNA. DR UniGene; Mm.316628; -. DR STRING; 10090.ENSMUSP00000103028; -. DR MGI; MGI:1889575; Adar. DR HOVERGEN; HBG067087; -. DR ChiTaRS; Adar; mouse. DR GO; GO:0005737; C:cytoplasm; IDA:MGI. DR GO; GO:0016020; C:membrane; ISO:MGI. DR GO; GO:0005730; C:nucleolus; IDA:MGI. DR GO; GO:0005654; C:nucleoplasm; ISO:MGI. DR GO; GO:0005634; C:nucleus; IDA:MGI. DR GO; GO:0044530; C:supraspliceosomal complex; ISO:MGI. DR GO; GO:0003726; F:double-stranded RNA adenosine deaminase activity; IDA:MGI. DR GO; GO:0003692; F:left-handed Z-DNA binding; TAS:MGI. DR GO; GO:0044822; F:poly(A) RNA binding; ISO:MGI. DR GO; GO:0006382; P:adenosine to inosine editing; IMP:MGI. DR GO; GO:0016553; P:base conversion or substitution editing; ISO:MGI. DR GO; GO:0051607; P:defense response to virus; IMP:MGI. DR GO; GO:0060216; P:definitive hemopoiesis; IMP:MGI. DR GO; GO:0030218; P:erythrocyte differentiation; IMP:MGI. DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IMP:MGI. DR GO; GO:0061484; P:hematopoietic stem cell homeostasis; IMP:MGI. DR GO; GO:0001701; P:in utero embryonic development; IMP:MGI. DR GO; GO:0035280; P:miRNA loading onto RISC involved in gene silencing by miRNA; ISO:MGI. DR GO; GO:0043066; P:negative regulation of apoptotic process; IMP:MGI. DR GO; GO:0044387; P:negative regulation of protein kinase activity by regulation of protein phosphorylation; ISO:MGI. DR GO; GO:1900369; P:negative regulation of RNA interference; IMP:MGI. DR GO; GO:0060339; P:negative regulation of type I interferon-mediated signaling pathway; IMP:MGI. DR GO; GO:0045071; P:negative regulation of viral genome replication; IMP:MGI. DR GO; GO:0001649; P:osteoblast differentiation; IMP:MGI. DR GO; GO:0045070; P:positive regulation of viral genome replication; ISO:MGI. DR GO; GO:0031054; P:pre-miRNA processing; ISO:MGI. DR GO; GO:0035196; P:production of miRNAs involved in gene silencing by miRNA; IMP:MGI. DR GO; GO:0006611; P:protein export from nucleus; ISO:MGI. DR GO; GO:0006606; P:protein import into nucleus; ISO:MGI. DR GO; GO:0035455; P:response to interferon-alpha; ISO:MGI. DR GO; GO:0009615; P:response to virus; ISO:MGI. DR GO; GO:0002566; P:somatic diversification of immune receptors via somatic mutation; IDA:MGI. DR Gene3D; 3.30.160.20; -; 3. DR InterPro; IPR002466; A_deamin. DR InterPro; IPR014720; dsRBD_dom. DR Pfam; PF02137; A_deamin; 1. DR Pfam; PF00035; dsrm; 3. DR SMART; SM00552; ADEAMc; 1. DR SMART; SM00358; DSRM; 3. DR PROSITE; PS50141; A_DEAMIN_EDITASE; 1. DR PROSITE; PS50137; DS_RBD; 3. PE 2: Evidence at transcript level; FT NON_TER 1 1 {ECO:0000313|EMBL:BAE43048.1}. SQ SEQUENCE 705 AA; 77885 MW; 5B4268FC5FE96A37 CRC64; KLTECQLKNP VSGLLEYAQF TSQTCDFNLI EQSGPSHEPR FKFQVVINGR EFPPAEAGSK KVAKQDAAVK AMAILLREAK AKDSGQPEDL SHCPMEEDSE KPAEAQAPSS SATSLFSGKS PVTTLLECMH KLGNSCEFRL LSKEGPAHDP KFQYCVAVGA QTFPPVSAPS KKVAKQMAAE EAMKALQEEA ASSADDQSGG ANTDSLDESM APNKIRRIGE LVRYLNTNPV GGLLEYARSH GFAAEFKLID QSGPPHEPKF VYQAKVGGRW FPAVCAHSKK QGKQDAADAA LRVLIGESEK AEQLGFAELP LSGSTFHDQI AMLSHRCFNA LTNSFQPSLL GRKILAAIIM KRDPEDMGVV VSLGTGNRCV KGDSLSLKGE TVNDCHAEII SRRGFIRFLY SELMKYNNHT AKNSIFELAR GGEKLQIKKT VSFHLYISTA PCGDGALFDK SCSDRAVEST ESRHYPVFEN PKQGKLRTKV ENGEGTIPVE SSDIVPTWDG IRLGERLRTM SCSDKILRWN VLGLQGALLT HFLQPVYLKS VTLGYLFSQG HLTRAICCRV TRDGKAFEDG LRYPFIVNHP KVGRVSVYDS KRQSGKTKET SVNWCMADGY DLEILDGTRG TVDGPGKELS RVSKKNIFLQ FKKLCSFRAR RDLLQLSYGE AKKAARDYDL AKNYFKKSLR DMGYGNWISK PQEEKNFYLC PVPND //