ID   ELB3B_HUMAN             Reviewed;         546 AA.
AC   Q3SY89; A0A0B4J2C8; Q3MI93;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2017, sequence version 2.
DT   17-JUN-2020, entry version 130.
DE   RecName: Full=Elongin-A3 member B;
DE            Short=EloA3B;
DE   AltName: Full=Elongin-A3-like-1;
DE            Short=EloA3-like-1;
DE   AltName: Full=RNA polymerase II transcription factor SIII subunit A3-like-1;
DE   AltName: Full=Transcription elongation factor B polypeptide 3C-like-1;
GN   Name=ELOA3B {ECO:0000312|HGNC:HGNC:31007};
GN   Synonyms=TCEB3CL {ECO:0000312|HGNC:HGNC:31007};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16177791; DOI=10.1038/nature03983;
RA   Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D.,
RA   Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J.,
RA   Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L.,
RA   Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A.,
RA   Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C.,
RA   Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K.,
RA   Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R.,
RA   Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 18.";
RL   Nature 437:551-555(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: SIII, also known as elongin, is a general transcription
CC       elongation factor that increases the RNA polymerase II transcription
CC       elongation past template-encoded arresting sites. Subunit A is
CC       transcriptionally active and its transcription activity is strongly
CC       enhanced by binding to the dimeric complex of the SIII regulatory
CC       subunits B and C (elongin BC complex). {ECO:0000250|UniProtKB:Q63187}.
CC   -!- SUBUNIT: Heterotrimer of an A (ELOA3, ELOA2, ELOA3, ELOA3B, ELOA3C or
CC       ELOA3D), ELOB and ELOC subunit. {ECO:0000250|UniProtKB:Q63187}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00649}.
CC   -!- DOMAIN: The BC-box, which mediates binding to the elongin BC complex,
CC       has the consensus sequence [APST]-L-x(3)-C-x(3)-[AILV].
CC       {ECO:0000250|UniProtKB:Q63187}.
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DR   EMBL; AC012254; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC103912; AAI03913.1; -; mRNA.
DR   EMBL; BC103913; AAI03914.1; -; mRNA.
DR   CCDS; CCDS42433.2; -.
DR   RefSeq; NP_001094287.1; NM_001100817.1.
DR   RefSeq; XP_005276693.1; XM_005276636.3.
DR   RefSeq; XP_011507118.1; XM_011508816.2.
DR   SMR; Q3SY89; -.
DR   STRING; 9606.ENSP00000479069; -.
DR   iPTMnet; Q3SY89; -.
DR   PhosphoSitePlus; Q3SY89; -.
DR   BioMuta; ELOA3B; -.
DR   DMDM; 121942972; -.
DR   PaxDb; Q3SY89; -.
DR   PRIDE; Q3SY89; -.
DR   ProteomicsDB; 61849; -.
DR   Antibodypedia; 78239; 1 antibodies.
DR   Ensembl; ENST00000611323; ENSP00000479069; ENSG00000278674.
DR   GeneID; 728929; -.
DR   KEGG; hsa:728929; -.
DR   UCSC; uc060owu.1; human.
DR   CTD; 728929; -.
DR   DisGeNET; 162699; -.
DR   EuPathDB; HostDB:ENSG00000275553.2; -.
DR   EuPathDB; HostDB:ENSG00000278674.1; -.
DR   GeneCards; ELOA3B; -.
DR   HGNC; HGNC:31007; ELOA3B.
DR   HPA; ENSG00000278674; Not detected.
DR   neXtProt; NX_Q3SY89; -.
DR   OpenTargets; ENSG00000278674; -.
DR   PharmGKB; PA134878695; -.
DR   eggNOG; KOG2821; Eukaryota.
DR   eggNOG; ENOG4110PG3; LUCA.
DR   GeneTree; ENSGT00390000002428; -.
DR   HOGENOM; CLU_021679_0_0_1; -.
DR   InParanoid; Q3SY89; -.
DR   KO; K15076; -.
DR   OMA; VNIRSAQ; -.
DR   OrthoDB; 1174517at2759; -.
DR   PhylomeDB; Q3SY89; -.
DR   TreeFam; TF317259; -.
DR   Reactome; R-HSA-112382; Formation of RNA Pol II elongation complex.
DR   Reactome; R-HSA-167152; Formation of HIV elongation complex in the absence of HIV Tat.
DR   Reactome; R-HSA-167200; Formation of HIV-1 elongation complex containing HIV-1 Tat.
DR   Reactome; R-HSA-167238; Pausing and recovery of Tat-mediated HIV elongation.
DR   Reactome; R-HSA-167243; Tat-mediated HIV elongation arrest and recovery.
DR   Reactome; R-HSA-167246; Tat-mediated elongation of the HIV-1 transcript.
DR   Reactome; R-HSA-167287; HIV elongation arrest and recovery.
DR   Reactome; R-HSA-167290; Pausing and recovery of HIV elongation.
DR   Reactome; R-HSA-674695; RNA Polymerase II Pre-transcription Events.
DR   Reactome; R-HSA-6796648; TP53 Regulates Transcription of DNA Repair Genes.
DR   Reactome; R-HSA-75955; RNA Polymerase II Transcription Elongation.
DR   BioGRID-ORCS; 728929; 263 hits in 442 CRISPR screens.
DR   Pharos; Q3SY89; Tdark.
DR   PRO; PR:Q3SY89; -.
DR   Proteomes; UP000005640; Chromosome 18.
DR   RNAct; Q3SY89; protein.
DR   Bgee; ENSG00000275553; Expressed in urinary bladder and 11 other tissues.
DR   Genevisible; Q3SY89; HS.
DR   GO; GO:0070449; C:elongin complex; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   Gene3D; 1.20.930.10; -; 1.
DR   InterPro; IPR010684; RNA_pol_II_trans_fac_SIII_A.
DR   InterPro; IPR003617; TFIIS/CRSP70_N_sub.
DR   InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR   InterPro; IPR017923; TFIIS_N.
DR   Pfam; PF06881; Elongin_A; 1.
DR   Pfam; PF08711; Med26; 1.
DR   SMART; SM00509; TFS2N; 1.
DR   SUPFAM; SSF47676; SSF47676; 1.
DR   PROSITE; PS51319; TFIIS_N; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..546
FT                   /note="Elongin-A3 member B"
FT                   /id="PRO_0000343428"
FT   DOMAIN          5..80
FT                   /note="TFIIS N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00649"
FT   REGION          336..345
FT                   /note="BC-box"
FT                   /evidence="ECO:0000250|UniProtKB:Q63187"
FT   COMPBIAS        119..193
FT                   /note="Pro-rich"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00015"
FT   CONFLICT        301
FT                   /note="C -> S (in Ref. 2; AAI03913/AAI03914)"
FT   CONFLICT        304
FT                   /note="A -> T (in Ref. 2; AAI03913/AAI03914)"
FT   CONFLICT        375
FT                   /note="L -> P (in Ref. 2; AAI03913/AAI03914)"
SQ   SEQUENCE   546 AA;  59760 MW;  E98AE3DD548C5492 CRC64;
     MAAGSTTLRA VGKLQVRLAT KTEPKKLEKY LQKLSALPMT ADILAETGIR KTVKRLRKHQ
     HVGDFARDLA ARWKKLVLVD RNTGPDPQDP EESASRQRFG EALQEREKAW GFPENATAPR
     SPSHSPEHRR TARRTPPGQQ RPHPRSPSRE PRAERKRPRM APADSGPHRD PPTRTAPLPM
     PEGPEPAVPG EQPGRGHAHA AQGGPLLGQG CQGQPQGEAV GSHSKGHKSS RGASAQKSPP
     VQESQSERLQ AAGADSAGPK TVPSHVFSEL WDPSEAWMQA NYDLLSAFEA MTSQANPEAL
     CAPALQEEAA FPGRRVNAKM PVYSGSRPAC QLQVPTLRQQ CLRVPRNNPD ALGDVEGVPY
     SVLEPVLEGW TPDQLYRTEK DNAALARETD ELWRIHCLQD FKEEKPQEHE SWRELYLRLR
     DAREQRLRVV TTKIRSAREN KPSGRQTKMI CFNSVAKTPY DASRRQEKSA GAADPGNGEM
     EPAPKPAGSS QAPSGLGDGD GGSVSGGGSS NRHAAPADKT RKQAAKKVAP LMAKAIRDYK
     GRFSRR
//