ID KR133_HUMAN Reviewed; 172 AA. AC Q3SY46; Q3LI78; DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot. DT 11-OCT-2005, sequence version 1. DT 27-NOV-2024, entry version 111. DE RecName: Full=Keratin-associated protein 13-3; GN Name=KRTAP13-3; Synonyms=KAP13.3; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Small intestine; RA Obayashi I., Shibuya K., Kudoh J., Shimizu N.; RT "Identification of eight novel genes from keratin associated protein gene RT cluster on human chromosome 21q22.11."; RL Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are CC embedded in an interfilamentous matrix, consisting of hair keratin- CC associated proteins (KRTAP), which are essential for the formation of a CC rigid and resistant hair shaft through their extensive disulfide bond CC cross-linking with abundant cysteine residues of hair keratins. The CC matrix proteins include the high-sulfur and high-glycine-tyrosine CC keratins (By similarity). {ECO:0000250}. CC -!- SUBUNIT: Interacts with hair keratins. {ECO:0000250}. CC -!- INTERACTION: CC Q3SY46; Q9NX04: AIRIM; NbExp=3; IntAct=EBI-10241252, EBI-8643161; CC Q3SY46; Q7Z3C6-3: ATG9A; NbExp=5; IntAct=EBI-10241252, EBI-12006308; CC Q3SY46; P54253: ATXN1; NbExp=3; IntAct=EBI-10241252, EBI-930964; CC Q3SY46; Q9NWQ9: C14orf119; NbExp=3; IntAct=EBI-10241252, EBI-725606; CC Q3SY46; Q68D86: CCDC102B; NbExp=3; IntAct=EBI-10241252, EBI-10171570; CC Q3SY46; Q96HB5: CCDC120; NbExp=3; IntAct=EBI-10241252, EBI-744556; CC Q3SY46; Q2TAC2-2: CCDC57; NbExp=3; IntAct=EBI-10241252, EBI-10961624; CC Q3SY46; O95833: CLIC3; NbExp=5; IntAct=EBI-10241252, EBI-10192241; CC Q3SY46; P27658: COL8A1; NbExp=3; IntAct=EBI-10241252, EBI-747133; CC Q3SY46; P05813: CRYBA1; NbExp=3; IntAct=EBI-10241252, EBI-7043337; CC Q3SY46; P53672: CRYBA2; NbExp=3; IntAct=EBI-10241252, EBI-750444; CC Q3SY46; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-10241252, EBI-3867333; CC Q3SY46; P50570-2: DNM2; NbExp=3; IntAct=EBI-10241252, EBI-10968534; CC Q3SY46; Q86UW9: DTX2; NbExp=3; IntAct=EBI-10241252, EBI-740376; CC Q3SY46; O95967: EFEMP2; NbExp=5; IntAct=EBI-10241252, EBI-743414; CC Q3SY46; P16930: FAH; NbExp=3; IntAct=EBI-10241252, EBI-4397076; CC Q3SY46; O75593: FOXH1; NbExp=3; IntAct=EBI-10241252, EBI-1759806; CC Q3SY46; P23769: GATA2; NbExp=3; IntAct=EBI-10241252, EBI-2806671; CC Q3SY46; Q9Y223-2: GNE; NbExp=3; IntAct=EBI-10241252, EBI-11975289; CC Q3SY46; O95872: GPANK1; NbExp=3; IntAct=EBI-10241252, EBI-751540; CC Q3SY46; Q9Y4H4: GPSM3; NbExp=3; IntAct=EBI-10241252, EBI-347538; CC Q3SY46; P28799: GRN; NbExp=3; IntAct=EBI-10241252, EBI-747754; CC Q3SY46; Q96NT3-2: GUCD1; NbExp=5; IntAct=EBI-10241252, EBI-11978177; CC Q3SY46; Q96MH2: HEXIM2; NbExp=3; IntAct=EBI-10241252, EBI-5460660; CC Q3SY46; P49639: HOXA1; NbExp=3; IntAct=EBI-10241252, EBI-740785; CC Q3SY46; P31273: HOXC8; NbExp=3; IntAct=EBI-10241252, EBI-1752118; CC Q3SY46; Q9H2F3: HSD3B7; NbExp=3; IntAct=EBI-10241252, EBI-3918847; CC Q3SY46; P04792: HSPB1; NbExp=3; IntAct=EBI-10241252, EBI-352682; CC Q3SY46; Q96MP8-2: KCTD7; NbExp=3; IntAct=EBI-10241252, EBI-11954971; CC Q3SY46; Q7L273: KCTD9; NbExp=3; IntAct=EBI-10241252, EBI-4397613; CC Q3SY46; O60333-2: KIF1B; NbExp=3; IntAct=EBI-10241252, EBI-10975473; CC Q3SY46; Q5T749: KPRP; NbExp=3; IntAct=EBI-10241252, EBI-10981970; CC Q3SY46; P78385: KRT83; NbExp=3; IntAct=EBI-10241252, EBI-10221390; CC Q3SY46; P60412: KRTAP10-11; NbExp=3; IntAct=EBI-10241252, EBI-10217483; CC Q3SY46; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-10241252, EBI-11953334; CC Q3SY46; Q9BYR8: KRTAP3-1; NbExp=3; IntAct=EBI-10241252, EBI-9996449; CC Q3SY46; Q9BYR7: KRTAP3-2; NbExp=3; IntAct=EBI-10241252, EBI-751260; CC Q3SY46; Q6L8G4: KRTAP5-11; NbExp=3; IntAct=EBI-10241252, EBI-11993296; CC Q3SY46; Q6L8G9: KRTAP5-6; NbExp=3; IntAct=EBI-10241252, EBI-10250562; CC Q3SY46; Q9BYQ4: KRTAP9-2; NbExp=3; IntAct=EBI-10241252, EBI-1044640; CC Q3SY46; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-10241252, EBI-1043191; CC Q3SY46; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-10241252, EBI-739832; CC Q3SY46; Q17RB8: LONRF1; NbExp=3; IntAct=EBI-10241252, EBI-2341787; CC Q3SY46; Q9UH92-3: MLX; NbExp=3; IntAct=EBI-10241252, EBI-8852072; CC Q3SY46; Q9HC98-4: NEK6; NbExp=3; IntAct=EBI-10241252, EBI-11750983; CC Q3SY46; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-10241252, EBI-945833; CC Q3SY46; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-10241252, EBI-22310682; CC Q3SY46; P32242: OTX1; NbExp=3; IntAct=EBI-10241252, EBI-740446; CC Q3SY46; P55771: PAX9; NbExp=3; IntAct=EBI-10241252, EBI-12111000; CC Q3SY46; Q92824-2: PCSK5; NbExp=3; IntAct=EBI-10241252, EBI-11956269; CC Q3SY46; Q12837: POU4F2; NbExp=3; IntAct=EBI-10241252, EBI-17236143; CC Q3SY46; O60260-5: PRKN; NbExp=3; IntAct=EBI-10241252, EBI-21251460; CC Q3SY46; Q9Y2K5: R3HDM2; NbExp=3; IntAct=EBI-10241252, EBI-948428; CC Q3SY46; Q93062-3: RBPMS; NbExp=3; IntAct=EBI-10241252, EBI-740343; CC Q3SY46; Q06455-2: RUNX1T1; NbExp=3; IntAct=EBI-10241252, EBI-11984663; CC Q3SY46; O75093: SLIT1; NbExp=3; IntAct=EBI-10241252, EBI-947791; CC Q3SY46; Q92922: SMARCC1; NbExp=3; IntAct=EBI-10241252, EBI-355653; CC Q3SY46; Q16637: SMN2; NbExp=3; IntAct=EBI-10241252, EBI-395421; CC Q3SY46; Q99932-2: SPAG8; NbExp=3; IntAct=EBI-10241252, EBI-11959123; CC Q3SY46; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-10241252, EBI-5235340; CC Q3SY46; Q8WWU5-7: TCP11; NbExp=3; IntAct=EBI-10241252, EBI-17721485; CC Q3SY46; Q8WW24: TEKT4; NbExp=5; IntAct=EBI-10241252, EBI-750487; CC Q3SY46; Q08117-2: TLE5; NbExp=5; IntAct=EBI-10241252, EBI-11741437; CC Q3SY46; O43711: TLX3; NbExp=3; IntAct=EBI-10241252, EBI-3939165; CC Q3SY46; Q9H0E2: TOLLIP; NbExp=5; IntAct=EBI-10241252, EBI-74615; CC Q3SY46; Q8IWR1: TRIM59; NbExp=3; IntAct=EBI-10241252, EBI-10262539; CC Q3SY46; Q6AZZ1: TRIM68; NbExp=3; IntAct=EBI-10241252, EBI-2130449; CC Q3SY46; Q96PN8: TSSK3; NbExp=3; IntAct=EBI-10241252, EBI-3918381; CC Q3SY46; Q9BZL1: UBL5; NbExp=3; IntAct=EBI-10241252, EBI-607755; CC Q3SY46; Q2TAL6: VWC2; NbExp=3; IntAct=EBI-10241252, EBI-11957238; CC Q3SY46; O76024: WFS1; NbExp=3; IntAct=EBI-10241252, EBI-720609; CC Q3SY46; Q9P2F9: ZNF319; NbExp=3; IntAct=EBI-10241252, EBI-11993110; CC Q3SY46; Q9Y3S2: ZNF330; NbExp=3; IntAct=EBI-10241252, EBI-373456; CC Q3SY46; Q96IQ9: ZNF414; NbExp=3; IntAct=EBI-10241252, EBI-744257; CC -!- SIMILARITY: Belongs to the PMG family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB096940; BAE46355.1; -; mRNA. DR EMBL; BC103965; AAI03966.1; -; mRNA. DR CCDS; CCDS13591.1; -. DR RefSeq; NP_853653.1; NM_181622.1. DR AlphaFoldDB; Q3SY46; -. DR BioGRID; 130645; 90. DR IntAct; Q3SY46; 89. DR STRING; 9606.ENSP00000375109; -. DR iPTMnet; Q3SY46; -. DR PhosphoSitePlus; Q3SY46; -. DR BioMuta; KRTAP13-3; -. DR DMDM; 82592929; -. DR MassIVE; Q3SY46; -. DR PaxDb; 9606-ENSP00000375109; -. DR PeptideAtlas; Q3SY46; -. DR Antibodypedia; 64674; 79 antibodies from 15 providers. DR DNASU; 337960; -. DR Ensembl; ENST00000390690.3; ENSP00000375109.2; ENSG00000240432.4. DR GeneID; 337960; -. DR KEGG; hsa:337960; -. DR MANE-Select; ENST00000390690.3; ENSP00000375109.2; NM_181622.2; NP_853653.1. DR UCSC; uc002yob.2; human. DR AGR; HGNC:18925; -. DR CTD; 337960; -. DR GeneCards; KRTAP13-3; -. DR HGNC; HGNC:18925; KRTAP13-3. DR HPA; ENSG00000240432; Not detected. DR neXtProt; NX_Q3SY46; -. DR PharmGKB; PA134901486; -. DR VEuPathDB; HostDB:ENSG00000240432; -. DR eggNOG; ENOG502STG2; Eukaryota. DR GeneTree; ENSGT00940000161951; -. DR HOGENOM; CLU_111618_0_0_1; -. DR InParanoid; Q3SY46; -. DR OMA; LYSGCHK; -. DR OrthoDB; 4739128at2759; -. DR PhylomeDB; Q3SY46; -. DR TreeFam; TF337331; -. DR PathwayCommons; Q3SY46; -. DR Reactome; R-HSA-6805567; Keratinization. DR SignaLink; Q3SY46; -. DR BioGRID-ORCS; 337960; 7 hits in 1126 CRISPR screens. DR GenomeRNAi; 337960; -. DR Pharos; Q3SY46; Tdark. DR PRO; PR:Q3SY46; -. DR Proteomes; UP000005640; Chromosome 21. DR RNAct; Q3SY46; protein. DR Bgee; ENSG00000240432; Expressed in primordial germ cell in gonad and 2 other cell types or tissues. DR GO; GO:0005829; C:cytosol; TAS:Reactome. DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW. DR InterPro; IPR007951; KRTAP_PMG. DR Pfam; PF05287; PMG; 1. PE 1: Evidence at protein level; KW Keratin; Reference proteome; Repeat. FT CHAIN 1..172 FT /note="Keratin-associated protein 13-3" FT /id="PRO_0000185202" FT REPEAT 46..55 FT /note="1" FT REPEAT 56..65 FT /note="2" FT REPEAT 66..75 FT /note="3" FT REPEAT 76..85 FT /note="4" FT REPEAT 92..101 FT /note="5" FT REGION 46..101 FT /note="5 X 10 AA approximate repeats" FT CONFLICT 13 FT /note="C -> R (in Ref. 1; BAE46355)" FT /evidence="ECO:0000305" FT CONFLICT 18 FT /note="Y -> H (in Ref. 1; BAE46355)" FT /evidence="ECO:0000305" FT CONFLICT 108 FT /note="C -> R (in Ref. 1; BAE46355)" FT /evidence="ECO:0000305" SQ SEQUENCE 172 AA; 19236 MW; 230EA3775278CBF3 CRC64; MSYNCCSRNF SSCSHGGYLH YPGSSCGSSY PSNLVYSTDL CSPSTCQLGS SLYRGCQETC WRPNSCQTLC VESSPCHTSC YYPRTHMLCN SCLTMHVGSR GFGSNSCCSL SCGSRSCSSL GCGSNGFRYL NYRIHTSPSQ SYRSRFCHPI YFPPRRWFHS SCYQPFCRSG FY //