ID   ZN718_HUMAN             Reviewed;         478 AA.
AC   Q3SXZ3; A0A075B7G5; A8WFQ3; Q3SXZ4; Q3SXZ5;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   28-MAR-2018, sequence version 2.
DT   28-JUN-2023, entry version 128.
DE   RecName: Full=Zinc finger protein 718;
GN   Name=ZNF718;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1] {ECO:0000312|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP   ARG-413.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q3SXZ3-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q3SXZ3-2; Sequence=VSP_018110;
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DR   EMBL; AC253576; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC104026; AAI04027.1; -; mRNA.
DR   EMBL; BC104027; AAI04028.1; -; mRNA.
DR   EMBL; BC104028; AAI04029.1; -; mRNA.
DR   EMBL; BC104029; AAI04030.1; -; mRNA.
DR   EMBL; BC154406; AAI54407.1; -; mRNA.
DR   CCDS; CCDS75078.1; -. [Q3SXZ3-1]
DR   CCDS; CCDS75079.1; -. [Q3SXZ3-2]
DR   RefSeq; NP_001034216.2; NM_001039127.5. [Q3SXZ3-1]
DR   RefSeq; NP_001276859.1; NM_001289930.1. [Q3SXZ3-2]
DR   RefSeq; NP_001276860.1; NM_001289931.1. [Q3SXZ3-2]
DR   RefSeq; XP_016863468.1; XM_017007979.1.
DR   RefSeq; XP_016863469.1; XM_017007980.1. [Q3SXZ3-2]
DR   AlphaFoldDB; Q3SXZ3; -.
DR   SMR; Q3SXZ3; -.
DR   BioGRID; 129101; 13.
DR   IntAct; Q3SXZ3; 1.
DR   STRING; 9606.ENSP00000480556; -.
DR   GlyGen; Q3SXZ3; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q3SXZ3; -.
DR   PhosphoSitePlus; Q3SXZ3; -.
DR   BioMuta; ZNF718; -.
DR   DMDM; 94730683; -.
DR   EPD; Q3SXZ3; -.
DR   jPOST; Q3SXZ3; -.
DR   MassIVE; Q3SXZ3; -.
DR   PeptideAtlas; Q3SXZ3; -.
DR   ProteomicsDB; 61826; -. [Q3SXZ3-1]
DR   ProteomicsDB; 61827; -. [Q3SXZ3-2]
DR   Antibodypedia; 73438; 27 antibodies from 9 providers.
DR   DNASU; 255403; -.
DR   Ensembl; ENST00000510175.6; ENSP00000480556.1; ENSG00000250312.8. [Q3SXZ3-1]
DR   Ensembl; ENST00000609714.1; ENSP00000476435.1; ENSG00000250312.8. [Q3SXZ3-2]
DR   GeneID; 255403; -.
DR   KEGG; hsa:255403; -.
DR   MANE-Select; ENST00000510175.6; ENSP00000480556.1; NM_001039127.6; NP_001034216.2.
DR   UCSC; uc032tae.2; human.
DR   AGR; HGNC:26889; -.
DR   CTD; 255403; -.
DR   GeneCards; ZNF718; -.
DR   HGNC; HGNC:26889; ZNF718.
DR   HPA; ENSG00000250312; Low tissue specificity.
DR   MIM; 618405; gene.
DR   neXtProt; NX_Q3SXZ3; -.
DR   OpenTargets; ENSG00000250312; -.
DR   PharmGKB; PA143485682; -.
DR   VEuPathDB; HostDB:ENSG00000250312; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000161765; -.
DR   InParanoid; Q3SXZ3; -.
DR   OMA; RKTCKSV; -.
DR   OrthoDB; 3120079at2759; -.
DR   PhylomeDB; Q3SXZ3; -.
DR   PathwayCommons; Q3SXZ3; -.
DR   Reactome; R-HSA-212436; Generic Transcription Pathway.
DR   SignaLink; Q3SXZ3; -.
DR   BioGRID-ORCS; 255403; 4 hits in 178 CRISPR screens.
DR   ChiTaRS; ZNF718; human.
DR   GenomeRNAi; 255403; -.
DR   Pharos; Q3SXZ3; Tdark.
DR   PRO; PR:Q3SXZ3; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   RNAct; Q3SXZ3; protein.
DR   Bgee; ENSG00000250312; Expressed in adrenal tissue and 117 other tissues.
DR   ExpressionAtlas; Q3SXZ3; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR   CDD; cd07765; KRAB_A-box; 1.
DR   Gene3D; 6.10.140.140; -; 1.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 11.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR036051; KRAB_dom_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR24384; FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED; 1.
DR   PANTHER; PTHR24384:SF208; ZINC FINGER PROTEIN 718; 1.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 9.
DR   Pfam; PF13912; zf-C2H2_6; 1.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 11.
DR   SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 6.
DR   SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE   2: Evidence at transcript level;
KW   Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW   Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..478
FT                   /note="Zinc finger protein 718"
FT                   /id="PRO_0000233286"
FT   DOMAIN          4..75
FT                   /note="KRAB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT   ZN_FING         171..193
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         199..221
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         227..249
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         255..277
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         283..305
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         311..333
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         339..361
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         367..389
FT                   /note="C2H2-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         395..417
FT                   /note="C2H2-type 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         423..445
FT                   /note="C2H2-type 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         451..473
FT                   /note="C2H2-type 11"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   VAR_SEQ         1..32
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_018110"
FT   VARIANT         140
FT                   /note="K -> N (in dbSNP:rs9684215)"
FT                   /id="VAR_059933"
FT   VARIANT         140
FT                   /note="K -> R (in dbSNP:rs9684214)"
FT                   /id="VAR_059934"
FT   VARIANT         297
FT                   /note="S -> Y (in dbSNP:rs7677201)"
FT                   /id="VAR_059935"
FT   VARIANT         413
FT                   /note="H -> R (in dbSNP:rs7440274)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_059936"
FT   CONFLICT        23
FT                   /note="T -> I (in Ref. 2; AAI04030)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        46
FT                   /note="S -> T (in Ref. 2; AAI04027/AAI04029/AAI04030)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   478 AA;  55359 MW;  8362FA9A3A982FFD CRC64;
     MELLTFKDVA IEFSPEEWKC LDTSQQNLYR DVMLENYRNL VSLGVSISNP DLVTSLEQRK
     EPYNLKIHET AARPPAVCSH FTQNLWTVQG IEDSFHKLIP KGHEKRGHEN LRKTCKSINE
     CKVQKGGYNR INQCLLTTQK KTIQSNICVK VFHKFSNSNK DKIRYTGDKT FKCKECGKSF
     HVLSRLTQHK RIHTGENPYT CEECGKAFNW SSILTKHKRI HAREKFYKCE ECGKGFTRSS
     HLTKHKRIHT GEKPYICEKC GKAFNQSSTL NLHKRIHSAQ KYYKCEECGK AFKWSSSLNE
     HKRIHAGEKP FSCEECGNVF TTSSDFAKHK RIHTGEKPYK CEECGKSFNR STTLTTHKRI
     HTGEKPYTCE ECGKAFNWSS TLNVHKRIHS GKNPYKCEDC GKAFKVFANL HNHKKIHTGE
     KPYICKQCGK AFKQSSHLNK HKKIHTVDKP YKCKECGKAF KQYSNLPQHK RTHTGGKF
//